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Immunostimulation

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Book cover Immunopharmacology

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Abstract

The removal of a foreign antigen from a macroorganism requires a variety of reactions. Those that involve the recognition of the antigen by lymphocytes and a subsequent cellular or humoral immune response are classified as “specific”. Others which entail the uptake and degradation of foreign materials by macrophages and related cells can be called “unspecific”. Sometimes the events leading to the elimination of an antigen are quite simple. Certain antigens such as extracellular bacteria which have entered the host tissues are rapidly opsonized by pre-existing antibodies and then phagocytosed and killed by neutrophilic granulocytes or macrophages. This is the simplest case. Often, however, there are no opsonizing antibodies present, or — if there are — they have no bearing on the mechanism by which a particular antigen is eliminated from the body.

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References

  • Adams DO, Hamilton TA (1984): The cell biology of macrophage activation. Ann Rev Immunol, Vol 2, 283–318.

    Article  CAS  Google Scholar 

  • Arrigoni-Martelli E (1981): Developments in drugs enhancing the immune responses. Meth and Find Exptl Clin Pharmacol, Vol 3 (4), 247–270.

    CAS  Google Scholar 

  • Drews J (1984): Die Pharmakologie des Immunsystems: Klinische und experimentelle Perspekti-ven. In: Progress in Drug Research, Vol 28, 83–109. (E Jucker ed).

    Google Scholar 

  • Drews J (1984): The experimental and clinical use of immune-modulating drugs in the prophylaxis and treatment of infections. Infection, Vol 12, 157–166.

    Article  PubMed  CAS  Google Scholar 

  • Fidler IJ (1985): Macrophages and metastasis — A biological approach to cancer therapy: Presidential address. Cancer Research, Vol 45, 4714–4726.

    PubMed  CAS  Google Scholar 

  • Grob PJ, Fontana A (1982): Immunstimulantien und Infektionskrankheiten.Therap Umsch, Vol 39, No 9, 668–674.

    CAS  Google Scholar 

  • Mertelsmann R, Welte K (1986): Human interleukin 2: Molecular biology, physiology and clinical possibilities. Immunobiol, Vol 172, 400 — 419.

    Article  CAS  Google Scholar 

  • Metcalf D (1985): The granulocyte-macrophage colony-stimulating factors. Science, Vol 229, 16–22.

    Article  PubMed  CAS  Google Scholar 

  • Mihich E (1986): Future perspectives for biological response modifiers: A viewpoint. Seminars in Oncology, Vol 13, No 2, 234–254.

    PubMed  CAS  Google Scholar 

  • Mihich E, Fefer A (eds) (1983): Biological response modifiers: Subcommittee Report. Subcommittee on Biological Response Modifiers. Board of Scientific Counselors, Division of Cancer Treatment. National Cancer Institute.

    Google Scholar 

  • Nicola NA (1987): Why do hemopoietic growth factor receptors interact with each other? Immunology Today, Vol 8, No 5, 134–140.

    Article  Google Scholar 

  • Oettgen HF, Old LJ (1987): Tumor necrosis factor. Important Adv Oncol, Vol. 1987, 105–130.

    Google Scholar 

  • Patterson R, Norman P (1982): Immunotherapy-lmmunomodulation. JAMA, Vol 248, No 20, 2759–2772.

    Article  PubMed  CAS  Google Scholar 

  • Smith KA (1988): Interleukin-2: Inception, impact, and implications. Science, Vol 240, 1169–1176.

    Article  PubMed  CAS  Google Scholar 

  • Umezawa H (1980): Low-molecular-weight immunomodulators produced by microorganisms. Biotechnol Bioengineering, Vol XXII, Suppl 1, 99–110.

    Google Scholar 

  • Werner GH, Floc F, Migliore-Samour D, Jollès P (1986): Immunomodulating peptides. Experientia, Vol 42, 521–531

    Article  PubMed  CAS  Google Scholar 

  • Abeles JH (1982): Inosiplex in recurrent herpes simplex infection. Lancet, 926.

    Google Scholar 

  • Andrus L, Granelli-Piperno A, Reich E (1984): Cytotoxic T cells both produce and respond to interleukin 2. J Exp Med, Vol 59, 647–652.

    Article  Google Scholar 

  • Arvin AM, Kushner JH, Feldman S, Baehner RL, Hammond D, Merigan TC (1982): Human leukocyte interferon for the treatment of varicella in children with cancer. New Engl J Med, Vol 306, No 13, 761–765.

    Article  PubMed  CAS  Google Scholar 

  • Ashorn RG, Vandenbark AA, Acott KM, Krohn KJ (1986): Dialysable leukocyte extracts (transfer factor) augment nonspecifically keyhole limpet haemocyanin and horseshoe crab haemocyanin skin reactivity in unimmunized human recipients. Scand J Immunol, Vol 23, 161–167.

    Article  PubMed  CAS  Google Scholar 

  • Attallah AM, Petricciani JC, Galasso GJ, Rabson AS (1980): Report of a workshop on standards for human interferon in clinical trials. J Infect Dis, Vol 142, No 2, 300–301.

    Article  Google Scholar 

  • Avella J, Binder HJ, Madsen JE, Askenase PW (1978): Effect of histamine H2-receptor antagonists on delayed hypersensitivity. Lancet, 624–626.

    Google Scholar 

  • Bach JF, Bach MA, Blanot D et al (1978): Thymic serum factor. Bull Inst Pasteur, Vol 76, 325– 330.

    Google Scholar 

  • Ballet JJ, Morin A, Schmitt C, Agrapart M (1982): Effect of isoprinosine on in vitro proliferative responses of human lymphocytes stimulated by antigen. Int J Immunopharm, Vol 4, No 3, 151–157.

    Google Scholar 

  • Barret DJ, Wara DW, Ammann AJ et al (1980): Thymosin therapy in Di George-Syndrome. The Journal of Pediatrics, Vol 97, 66–71.

    Article  Google Scholar 

  • Begley CG, Metealf D, Nicola NA (1986): Primary human myeloid leukemia cells: comparative responsiveness to proliferative stimulation by GM-CSF or G-CSF and membrane expression of CSF receptors. Leukemia, Vol 1, 1–8.

    Google Scholar 

  • Bennett J, Zloty P, McKneally M (1982): Cimetidine blocks the development of tumor-induced suppressor T-cell activity. J Int Immunopharmacol, Vol 4, 280.

    Article  Google Scholar 

  • Bergstrand H, Hegardt B, Lowhagen O, Strannegard O, Svedmyr N (1985): Effects of long-term treatment with low dose Cimetidine on allergen-induced airway responses and selected immunolo-gical parameters in atopic asthmatics. Allergy, Vol 40, 187–197.

    Article  PubMed  CAS  Google Scholar 

  • Berkman N, Legoix H, Moubri M, de Saxe E (1979): Action favorable de Fisoprinosine au cours des affections oculaires virales et inflammatoires. La Nouvelle Presse Médicale, Vol 8, No 46, 3829–3830.

    CAS  Google Scholar 

  • Beutler B, Cerami A (1988): The common mediator of shock, cachexia, and tumor necrosis. Advances in Immunology, Vol 42, 213–231.

    Article  PubMed  CAS  Google Scholar 

  • Bicker U, Ziegler AE, Heboid G (1979): Investigations in mice on the potentiation of resistance to infections by a new immunostimulant compound. J Infect Dis, Vol 139, 389–395.

    Article  PubMed  CAS  Google Scholar 

  • Blomgren H, Edsmayr F, von Stedingk L-V, Wasserman J (1986): Bestatin treatment enhances the recovery of radiation induced impairments of the immunological reactivity of the blood lymphocyte population in bladder cancer patients. Biomedicine & Pharmacotherapy, Vol 40, 50–54.

    CAS  Google Scholar 

  • Bocci V (1981): Pharmacokinetic studies of interferons. Pharmac Ther, Vol 13, 421–440.

    Article  CAS  Google Scholar 

  • Borden EC (1979): Interferons: Rationale for clinical trials in neoplastic disease. Ann Intern Med, Vol 91, 472–479.

    PubMed  CAS  Google Scholar 

  • Borden EC, Holland JF, Dao TL, Gutterman JU, Wiener L, Chang Y-Ch, Patel J (1982): Leucocyte-derived interferon (alpha) in human breast carcinoma. Ann Intern Med, Vol 97, 1–6.

    PubMed  CAS  Google Scholar 

  • Bornemann LD, Spiegel HE, Dziewanowska ZE, Krown S, Colburn WA (1985): Intravenous and intramuscular pharmacokinetics of recombinant leukocyte A interferon. Eur J Clin Pharmacol, Vol 28, No 4, 469–471.

    Article  PubMed  CAS  Google Scholar 

  • Boylston AW, Vose BM (1983): Potential use of purified interleukin 2 as a therapeutic agent. Clin Immunol Allergy, Vol 3 /2, 229–234.

    CAS  Google Scholar 

  • Brandt SJ, Peters WP, Atwater SK, Kurtzberg J, Borowitz MJ, Jones RB, Shpall EJ, Bast RC, Gilbert CJ, Oette DH (1988): Effect of recombinant human granulocyte-macrophage colony- stimulating factor on hematopoietic reconstitution after high-dose chemotherapy and autologous bone marrow transplantation. New Engl J Med, Vol 318, 869–876.

    Article  PubMed  CAS  Google Scholar 

  • Bricaire F (1981): L’interferon. La Nouvelle Presse Médicale, Vol 10, No 7, 458–461.

    CAS  Google Scholar 

  • Brockmeyer NH, Kreuzfelder E, Mertins L, Chalabi N, Kirch W, Scheiermann N, Goos M, Ohnhaus EE (1988): Immunomodulatory properties of Cimetidine in ARC patients. Clin Immunol Immunopathol, Vol 48, 50–60.

    Article  PubMed  CAS  Google Scholar 

  • Bronchud MH, Scarffe JH, Thatcher N, Crowther D, Souza LM, Alton NK, Testa NG, Dexter TM (1987): Phase I/II study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer. Brit J Cancer, Vol 56, 809–813.

    Article  PubMed  CAS  Google Scholar 

  • Brown GL, Kellerman JS, Lamont P, Sciutto M, Berbos EA, Polk HC Jr (1985): Muramyl dipeptide and polymorphonuclear leukocyte Chemotaxis in vitro. J Surg Res, Vol 39, 128–132.

    Article  PubMed  CAS  Google Scholar 

  • Burger CJ, Elgert KD, Farrar WL (1984): Interleukin 2 (IL-2) activity during tumor growth: IL- 2 production, kinetics, absorption of and responses to exogenous IL-2. Cellular Immunology, Vol 84, 228–239.

    Article  PubMed  CAS  Google Scholar 

  • Cabrera EJ, Sergio SL (1986): Differential effect of isoprinosine on lymphocyte proliferation: Comparison of two tissue culture media. Int J Immunopharm, Vol 8, 893–896.

    Article  CAS  Google Scholar 

  • Cantrell DA, Smith KA (1984): The interleukin-2 T-cell system: A new cell growth model. Science (USA), Vol 224 /4655, 1312–1316.

    Article  PubMed  CAS  Google Scholar 

  • Carey JT, Lederman MM, Toossi Z, Edmonds K, Hodder S, Calabrese LH, Proffitt MR, Johnson CE, Ellner JJ (1987): Augmentation of skin test reactivity and lymphocyte blastogenesis in patients with AIDS treated with transfer factor. JAMA, Vol 257, 651 - 655.

    Article  PubMed  CAS  Google Scholar 

  • Carter WA, O’Malley J, Beeson M, Cunnington P, Kelvin A, Vere-Hodge A, Alderfer JL, Ts’o PO (1976): An integrated and comparative study of the antiviral effects and other biological properties of the polyinosinic-polycytidylic acid duplex and its mismatched analogues. Molecular Pharmacology, Vol 12, 400–453.

    Google Scholar 

  • Cesario ThC (1983): The clinical implications of human interferon. Med Clin North America, Vol 67, No 5, 1147–1162.

    CAS  Google Scholar 

  • Chalmers ThC, Smith H Jr (1982): Inosiplex for SSPE. Lancet, 1475.

    Google Scholar 

  • Charieras J-L, Plassart H (1982): Etude en double-insu de 59 cas de rougeole sévère traités par isoprinosine. Médecine tropicale, Vol 42, No 3, 316–318.

    Google Scholar 

  • Chedid LA, Parant MA, Audibert FM, Riveau GJ, Parant FJ, Lederer E, Choay JP, Lefrancier PL (1982): Biological activity of a new synthetic muramyl peptide adjuvant devoid of pyrogenicity. Infection and Immunity, Vol 35, No 2, 417–424.

    PubMed  CAS  Google Scholar 

  • Cheers C, Haigh AM, Kelso A, MetcalfD, Stanley ER, Young AM (1988): Production of colony- stimulating factors (CSFs) during infection: Separate determinations of macrophage-, granu-locyte-, granulocyte-macrophage-, and multi CSFs. Infection and Immunity, Vol 56, 247–251.

    CAS  Google Scholar 

  • Cheever MA, Greenberg PhD, Fefer A, Gillis St (1982): Augmentation of the antitumor thera-peutic efficacy of long-term cultured T lymphocytes by in vivo administration of purified interleu- kin 2. J Exp Med, Vol 155, 968–980.

    Article  PubMed  CAS  Google Scholar 

  • Chun M, Hoffmann MK (1982): Modulation of interferon-induced NK cells by interleukin 2 and cAMP. Lymphokine Research, Vol 1, No 4, 91–98.

    PubMed  CAS  Google Scholar 

  • Cohen MH, Chretien PB, Inde DC et al (1979): Thymosin fraction 5 and intensive combination chemotherapy. Prolonging the survival of patients with small cell lung cancer. JAMA, Vol 241, 1813–1815.

    Article  PubMed  CAS  Google Scholar 

  • Cohn ZA (1978): The activation of mononuclear phagocytes: Fact, fancy, and future. The Journal of Immunology, Vol 121, No 3, 813–816.

    PubMed  CAS  Google Scholar 

  • Converse PJ, Mshana RM, Bjune G J (1987): Cimetidine inhibits suppressor factor production in Ethiopian lepromatous leprosy patients. Int J Lepr Other Mycobact Dis, Vol 55, 548–553.

    PubMed  CAS  Google Scholar 

  • Creagh-Kirk T, Doi P, Andrews E, Nusinoff-Lehrman S, Tilson H, Hoth D, Barry DW (1988): Survival experience among patients with AIDS receiving zidovudine. JAMA, Vol 260, 3009–3015.

    Article  PubMed  CAS  Google Scholar 

  • Cryz SJ, Furer E, Germanier R (1984): Protection against fatal pseudomonas aeruginosa burn wound sepsis by immunization with lipopolysaccharide and high-molecular-weight polysaccharide. Infection and Immunity, Vol 43, No 3, 795–799.

    PubMed  CAS  Google Scholar 

  • Csaba G, Laszlo V, Kovacs P (1986): Effect of tuftsin on the phagocytotic activity of the unicellular Tetrahymena. Does primary interaction develop imprinting? Z Naturforsch, Vol 41, 805–806.

    CAS  Google Scholar 

  • Cummings NP, Pabst MJ, Johnston RB (1980): Activation of macrophages for enhanced release of superoxide anion and greater killing of Candida albicans by injection of muramyl dipeptide. J Exp Med, Vol 152, 1659–1669.

    Article  PubMed  CAS  Google Scholar 

  • Currie GA (1978): Activated macrophages kill tumour cells by releasing arginase. Nature, Vol 273, 758–759.

    Article  PubMed  CAS  Google Scholar 

  • Damais C, Riveau G, Parant M, Gerota J, Chedid L (1982): Production of lymphocyte activating factor in the absence of endogenous pyrogen by rabbit or human leukocytes stimulated by a muramyl dipeptide derivate. Int J Immunopharmac, Vol 4, No 5, 451–462.

    Article  CAS  Google Scholar 

  • De Simone C, Meli D, Sbricoli M, Rebuzzi E, Koverech A (1982): In vitro effect of inosiplex on T-lymphocytes. J Immunopharmacol, Vol 4, 139–152.

    PubMed  Google Scholar 

  • Delafuente JC, Panush RS (1988): Pharmacologic immunoenhancement in the elderly: In vitro effects of isoprinosine. Clin Immunol Immunopathol, Vol 47, 363–367.

    Article  PubMed  CAS  Google Scholar 

  • Di Luzio NR, Williams DL, Mc Namee RB, Edwards BF, Kitahama A (1979): Comparative tumor-inhibitory and anti-bacterial activity of soluble and particulate glucan. Int J Cancer, Vol 24, 773–779.

    Article  PubMed  Google Scholar 

  • Donahue RE, Wang EA, Stone DK, Kamen R, Wong GG, Sehgal PK, Nathan DG, Clark SC (1986): Stimulation of haematopoiesis in primates by continuous infusion of recombinant human GM-CSF. Nature, Vol 321, 872–875.

    Article  PubMed  CAS  Google Scholar 

  • Dournon E, Rozenbaum W, Michon C, Perrone C, De Truchis P, Bouvet E, Levacher M, Matherson S, Gharakhanian S, Girard PM, Salmon D, Leport C, Dazza MC, Regnier B (1988): Effects of zidovudine in 365 consecutive patients with AIDS or AIDS-related complex. Lancet, December 3, 1297–1302.

    Article  Google Scholar 

  • Du Rant RH, Dyken PR, Swift AV (1982): The influence of inosiplex treatment of the neurological disability of patients with subacute sclerosing panencephalitis. The Journal of Pediatrics, Vol 101, No 2, 288–293.

    Article  Google Scholar 

  • Dunnick JK, Galasso GJ (1979): Clinical trials with exogenous interferon: summary of a meeting. J Infect Dis, Vol 139, No 1, 109–123.

    Article  PubMed  CAS  Google Scholar 

  • Dunnick JK, Galasso GJ (1980): Update on clinical trials with exogenous interferon. J Infect Dis, Vol 142, No 2, 293–299.

    Article  PubMed  CAS  Google Scholar 

  • Dyken PR, Swift A, Du Rant RH (1981): Long-term follow-up of patients with subacute sclerosing panencephalitis treated with inosiplex. Annals of Neurology, Vol 11, No 4, 359–364.

    Article  Google Scholar 

  • Editorial (1982): Clinical uses of interferon. Bulletin of the World Health Organization, Vol 60, No 1, 37–38.

    Google Scholar 

  • Eisenthal A, Monselise J, Zinger R, Adler A (1986): The effect of Cimetidine on PBL from healthy donors and melanoma patients: Augmentation of T cell responses to TCGF, mitogens and alloan- tigens and of TCGF production. Cancer Immunol Immunother, Vol 21, 141–147.

    Article  PubMed  CAS  Google Scholar 

  • Eschenfeldt WH, Manrow RE, Krug MS, Berger SL (1989): Isolation and partial sequencing of the human prothymosin a gene family. The Journal of Biological Chemistry, Vol 264, No 13, 7546–7555.

    PubMed  CAS  Google Scholar 

  • Executive Committee of the Danish Breast Cancer Cooperative Group (1980): Increased breast cancer recurrence after adjuvant therapy with levamisole. Lancet II: 824–827.

    Google Scholar 

  • Feldmann JL, Mery C, Amor B, Kahan A, de Gery A, Delbarre F (1981): Effectiveness of levamisole in rheumatoid arthritis: Immune changes and long-term results. Scand J Rheumatol, Vol 10, 1–8

    Google Scholar 

  • Ferguson TA, Krieger NJ, Pesce A, Michael JG (1983): Enhancement of antigen-specific suppres-sion by muramyl dipeptide. Infection and Immunity, Vol 39, No 2, 800–806.

    PubMed  CAS  Google Scholar 

  • Fibbe WE, van Damme J, Billiau A, Goselink HM, Voogt PJ, van Eeden G, Ralph P, Altrock BW, Falkenburg JHF (1988): Interleukin 1 induces human marrow stromal cells in long-term culture to produce granulocyte colony-stimulating factor and macrophage colony-stimulating factor. Blood, Vol 71, 430–435.

    PubMed  CAS  Google Scholar 

  • Fidler IJ (1986): Optimization and limitations of systemic treatment of murine melanoma meta-stases with liposomes containing muramyl tripeptide phosphatidylethanolamine. Cancer Immunol Immunother, Vol 21, 169–173.

    Article  PubMed  CAS  Google Scholar 

  • Fidler IJ, Sone S, Fogler WE, Smith D, Braun DG, Tarcsay L, Gisler RH, Schroit AJ (1982): Efficacy of liposomes containing a lipophilic muramyl dipeptide derivative for activating the tumoricidal properties of alveolar macrophages in vivo. Journal of Biological Response Modifiers, Vol 1, 43–55.

    CAS  Google Scholar 

  • Fischer GW, Podgore JK, Bass JW, Kelley JL, Kobayashi GY (1975): Enhanced host defense mechanisms with levamisole in suckling rats. J Infect Dis, Vol 132, 578 - 581.

    Article  PubMed  CAS  Google Scholar 

  • Fischl MA, Richman DD, Grieco MH, Gottlieb MS, Volberding PA, Laskin OL, Leedom JM, Groopman JE, Mildvan D, Schooley RT, Jackson GG, Durack DT, King D (1987): The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. New Engl J Med, Vol 317, 185–191.

    Article  Google Scholar 

  • Fleischmann WR Jr (1982): Potentiation of the direct anticellular activity of mouse interferons: Mutual synergism and interferon concentration dependence. Cancer Research, Vol 42, 869–875.

    PubMed  CAS  Google Scholar 

  • Flodgren P, Hugander A, Sjogren HO (1985): Recombinant leukocyte A interferon as single agent therapy or in combination with Cimetidine in patients with advanced colo-rectal carcinoma. A phase II investigation. Acta Radiol (Oncol), Vol 24, 25–34.

    Article  CAS  Google Scholar 

  • Flury F, Wegmann T (1979): Klinische Erfahrungen bei der Therapie mit Interferon. Schweiz Rundschau Med (Praxis), Vol 68, 1401–1405.

    CAS  Google Scholar 

  • Fogler WE, Fidler IJ (1987): Comparative interaction of free and liposome-encapsulated nor- muramyl dipeptide or muramyl tripeptide phosphatidylethanolamine (3H-labelled) with human blood monocytes. Int J Immunopharm, Vol 9, 141–150.

    Article  CAS  Google Scholar 

  • Fogler WE, Wade R, Brundish DE, Fidler IJ (1985): Distribution and fate of free and liposome- encapsulated (3H)nor-muramyl dipeptide and (3H)muramyl tripeptide phosphatidylethanolamine in mice. The Journal of Immunology, Vol 135, No 2, 1372–1377.

    PubMed  CAS  Google Scholar 

  • Fraser-Smith E, Waters RV, Matthews TR (1982): Correlation between in vivo anti-pseudomonas and anti-candida activities and clearance of carbon by the reticuloendothelial system for various muramyl dipeptide analogs, using normal and immuno-suppressed mice. Infection and Immunity, Vol 35, No 1, 105–110.

    PubMed  CAS  Google Scholar 

  • Fraser-Smith EB, Eppstein DA, Larsen MA, Matthews TR (1983): Protective effect of a muramyl dipeptide analog encapsulated in or mixed with liposomes against Candida albicans infection. Infection and Immunity, Vol 39, No 1, 172–178

    PubMed  CAS  Google Scholar 

  • Fraser-Smith EB, Matthews TR (1981): Protective effect of a muramyl dipeptide derivate analogs against infections of Pseudomonas aeruginosa or Candida albicans in mice. Infection and Immunity, Vol 34, No 3, 676–683.

    PubMed  CAS  Google Scholar 

  • Frith JA, McLeod JG, Basten A, Pollard JD, Hammond SR, Williams DB, Crossie PA (1986): Transfer factor as a therapy for multiple sclerosis: A follow-up study. Clin Exp Neurol, Vol 22, 149–154.

    PubMed  CAS  Google Scholar 

  • Gabrilove JL, Welte K, Harris P, Platzer E, Lu L, Levi E, Mertelsmann R, Moore MAS (1986): Pluripoietin alpha: A second hematopoietic colony-stimulating factor produced by the human bladder carcinoma cell line 5637. Proc Natl Acad Sci USA, Vol 83, 2478–2482.

    Article  PubMed  CAS  Google Scholar 

  • Galbraith GM, Thiers BH, Jensen J, Hoehler F (1987): A randomized double-blind study of inosiplex (isoprinosine) therapy in patients with alopecia totalis. J Am Acad Dermatol, Vol 16, 977–983.

    Article  PubMed  CAS  Google Scholar 

  • Galelli A, Dosne AM, Morin A, Dubor F, Chedid L (1985): Stimulation of human endothelial cells by synthetic muramyl peptides: Production of colony-stimulating activity (CSA). Exp Hematol, Vol 13, 1157–1163.

    PubMed  CAS  Google Scholar 

  • Galelli A, le Garrec Y, Chedid L, Lefrancier P, Derrein M, Level M (1980): Macrophage stitnula- tion in vivo by an inactive muramyl dipeptide derivative after conjugation to a multi-poly (DL- alanyl)-poly (L-lysine) carrier. Infection and Immunity, Vol 28, No 1, 1–5.

    PubMed  CAS  Google Scholar 

  • Galli M, Lazzarin A, Moroni M, Zanussi C (1982): Inosiplex in recurrent herpes simplex infections. Lancet, 331–332.

    Google Scholar 

  • Gemsa D, Seitz M, Deimann W et al. (1981): Mediatoren aus Makrophagen. Allergologie, Vol 4 /6, 308–313.

    CAS  Google Scholar 

  • Gifford RRM, Ferguson RM, Voss BV (1981): Cimetidine reduction of tumour formation in mice. Lancet, 638–639.

    Google Scholar 

  • Gillio AP, Bonilla MA, Potter GK, Gabrilove JL, O’Reilly RJ, Souza LM, Welte K (1987): Effects of recombinant human granulocyte-colony stimulating factor on hematopoietic reconstitu- tion after autologous bone marrow transplantation in primates. Transplant Proceedings, Vol 19, 153–156.

    CAS  Google Scholar 

  • Girot R, Hamet M, Perignon JL, Guesnu M, Fox RM, Cartier P, Durandy A, Griscelli C (1983): Cellular immune deficiency in two siblings with hereditary orotic aciduria. New Engl J Med, Vol 308, 700–704.

    Article  PubMed  CAS  Google Scholar 

  • Glasky AJ, Gordon JF (1987): Isoprinosine (inosine pranobex BAN, INPX) in the treatment of AIDS and other acquired immunodeficiencies of clinical importance. Cancer Detection and Prevention, Supplement 1, 597–609.

    CAS  Google Scholar 

  • Goetz O (1981): Die Behandlung der subakuten sklerosierenden Panencephalitis mit Isoprinosin. Mschr Kinderheilkd, Vol 129, 655–657.

    CAS  Google Scholar 

  • Goldstein AL, Rossio JL (1978): Thymosin for immunodeficiency diseases and cancer. Compr Ther, Vol 4, 49–57.

    PubMed  CAS  Google Scholar 

  • Goldstein G (1975): The isolation of thymopoietin (thymin). Ann NY Acad Sci, Vol 249, 177–185.

    Article  PubMed  CAS  Google Scholar 

  • Goodman MG (1984): Inductive and differentiative signals delivered by C8-substituted guanine ribonucleosides. Immunology Today, Vol 5, No 11, 319–324.

    Article  CAS  Google Scholar 

  • Gordon J, Minks MA (1981): The interferon renaissance: Molecular aspects of induction and action. Microbiological Reviews, Vol 45, No 2, 244–266.

    PubMed  CAS  Google Scholar 

  • Granstein RD, Tominaga A, Greene MI (1984): Therapeutic use of interleukins: Experimental results. Surv Immunol Res (Switzerland), Vol 3/2–3, 127–134.

    Google Scholar 

  • Grekas D, Nakos V, Theocharides A, Spanos P, Arvanitakis C, Tourkarttonis A (1985): Prophy-lactic treatment with Cimetidine after renal transplantation. Nephron, Vol 40, 213–215.

    Article  PubMed  CAS  Google Scholar 

  • Guinan P, Crispen R, Rubenstein M (1987): BCG in management of superficial bladder cancer. Urology, Vol 30, No 6, 515–519.

    Article  PubMed  CAS  Google Scholar 

  • Gutterman JW, Blumenschein GR, Alexanian R, Yap H-Y, Buzdar AU et al. (1980): Leukocyte interferon-induced tumor regression in human metastatic breast cancer, multiple myeloma and malignant lymphoma. Ann Intern Med, Vol 93, 399–406.

    PubMed  CAS  Google Scholar 

  • Hansbrough JF, Zapata-Sirvent RL, Bender EM (1986): Prevention of alterations in postoperative lymphocyte subpopulations by Cimetidine and ibuprofen. Am J Surg, Vol 151, 249–255.

    Article  PubMed  CAS  Google Scholar 

  • Heinonen E, Grohn P, Tarkkanen J, Maiche A, Wasenius VM (1981): Transfer factor immuno-therapy in Hodgkin’s and non-Hodgkin’s lymphoma. Cancer Immunol Immunother, Vol 11, 73–79.

    Article  Google Scholar 

  • Hermanowicz A, Sliwinski Z, Kaczor R (1985): Effect of long-term therapy with sulphasalazine, levamisole, corticosteroids and ascorbic acid and of disease activity on polymorphonuclear leukocyte function in patients with ulcerative colitis. Hepatogastroenterology, Vol 32, 81–86.

    PubMed  CAS  Google Scholar 

  • Herrmann F, Mertelsmann R (1989): Tumornekrosefaktor. Dtsch med Wschr, Vol 114, 312–316.

    Article  PubMed  CAS  Google Scholar 

  • Hersey P, Bindon C, Bradley M, Hasic E (1984): Effect of isoprinosine on interleukin 1 and 2 production and on suppressor cell activity in pokeweed mitogen stimulated cultures of B and T * cells. Int J Immunopharm, Vol 6, No 4, 321–328.

    Article  CAS  Google Scholar 

  • Hibbs JB Jr, Remington JS, Stewart CC (1980): Modulation of immunity and host resistance by microorganisms. Pharmacol Ther, Vol 8, 37–69.

    Article  CAS  Google Scholar 

  • Hillerdal G, Kiviloog J, Nou E, Steinholtz L (1986): Corynebacterium parvum in malignant pleural effusion. A randomized prospective study. Eur J Respir Dis, Vol 69, 204–206.

    PubMed  CAS  Google Scholar 

  • Hirai N, Hill NO, Motoo Y, Osther K (1985): Cimetidine enhances interferon induce augmenta-tion of NK cell activity and suppresses interferon production. Acta Pathol Microbiol Immunol Scand ( C), Vol 93, 153–159.

    Google Scholar 

  • Hirschhorn R (1983): Metabolic defects and immunodeficiency disorders. New Engl J Med, Vol 308, 714 - 716.

    Article  PubMed  CAS  Google Scholar 

  • Hofschneider PH, Obert H-J (1982): Stand klinischer Interferonstudien in der Bundesrepublik Deutschland. Münch med Wschr, Vol 124, No 42, 911–914.

    CAS  Google Scholar 

  • Hooper JA, McDaniel MC, Thurman GB et al (1975): The purification and properties of bovine thymosin. Ann NY Acad Sci, Vol 249, 145–153.

    Article  Google Scholar 

  • Horning SJ, Levine JF, Miller RA, Rosenberg SA, Merigan TC (1982): Clinical and immunologic effects of recombinant leukocyte A interferon in eight patients with advanced cancer. JAMA, Vol 247, No 12, 1718–1722.

    Article  PubMed  CAS  Google Scholar 

  • Huttenlocher PR, Mattson RH (1979): Isoprinosine in subacute sclerosing panencephalitis. Neurology, Vol 29, 763–771.

    PubMed  CAS  Google Scholar 

  • Ikic D, Trajer D, Cupak K, Petricevic I, Prazic M, Soldo I, Jusic D, Smerdel S, Soos E (1981): The clinical use of human leukocyte interferon in viral infections. Intern J Clin Pharmacol Ther and Toxicol, Vol 19, No 11, 498–505.

    CAS  Google Scholar 

  • Ingimarsson S, Cantell K, Strander H (1979): Side effects of long-term treatment with human leukocyte interferon. J Infect Dis, Vol 140, No 4, 560–563.

    Article  PubMed  CAS  Google Scholar 

  • Jones CE, Dyken PR, Huttenlocher PR, Jabbour JT, Maxwell KW (1982): Inosiplex therapy in subacute sclerosing panencephalitis. Lancet, 1034–1037.

    Google Scholar 

  • Jorizzo JL, Sams WM, Jegasothy BV, Olansky AJ (1980): Cimetidine as an immunomodulator: Chronic mucocutaneous candidiasis as a model. Ann Intern Med, Vol 92, Part 1, 192–195.

    Google Scholar 

  • Jupin C, Parant M, Chedid L, Damais C (1987): Enhanced oxidative burst without interleukin 1 production by normal human polymorphonuclear leukocytes primed with muramyl dipeptides. Inflammation, Vol 11, 153–161.

    Article  PubMed  CAS  Google Scholar 

  • Karnovsky ML, Lazdins JK (1978): Biochemical criteria for activated macrophages. The Journal of Immunology. Vol 121, No 3, 809–812.

    PubMed  CAS  Google Scholar 

  • Kasushansky K, O’Hara PJ, Berkner K, Segal GM, Hagen FS, Adamson JW (1986): Genomic cloning, characterization, and multilineage growth-promoting activity of human granulocyte-ma-crophage colony-stimulating factor. Proc Natl Acad Sci USA, Vol 83, 3101–3105.

    Article  Google Scholar 

  • Kawasaki ES, Ladner MB, Wang Am, van Arsdell J, Warren KM, Coyne MY, Schweickart VL, Lee MT, Wilson KJ, Boosman A, Stanley ER, Ralph P, Mark DF (1985): Molecular cloning of a complementary DNA encoding human macrophage specific colony-stimulating factor (CSF-1). Science, Vol 230, 291–296.

    Article  PubMed  CAS  Google Scholar 

  • Kaye J, Janeway CA (1984): Induction of receptors for interleukin 2 requires T cell Ag: la receptor crosslinking and interleukin 1. Lymphokine Research, Vol 3, No 4, 175 - 182.

    PubMed  CAS  Google Scholar 

  • Kazanowska B, Steuden W, BoguslaWska-Jaworska J, Konopinska D (1987): The influence of synthetic tuftsin and its analogs on the function of granulocytes of children with acute lymphoblastic leukemia. Arch Immunol Ther Exp ( Warsz ), Vol 35, 169–173.

    Google Scholar 

  • Khakoo RA, Watson GW, Waldman RH, Ganguly R (1981): Effect of inosiplex (Isoprinosine) on induced human influenza A infection. J Antimicrob Chemother, Vol 7, 389–397.

    Article  PubMed  CAS  Google Scholar 

  • Khanna OP, Son DL, Mazer H, Read J, Nugent D, Cottone R, Heeg M, Rezvan M, Viek N, Uhlman R (1988): Superficial bladder cancer treated with intravesical bacillus Calmette-Guerin or adriamycin: Follow-up report. Urology, Vol 31, 287–293.

    Article  PubMed  CAS  Google Scholar 

  • Kikuchi Y, Oomori K, Kizawa I, Kato K (1985): Effects of Cimetidine on tumor growth and immune function in nude mice bearing human ovarian carcinoma. J Natl Cancer Inst, Vol 74, No 2, 495–498.

    PubMed  CAS  Google Scholar 

  • Kikuchi Y, Oomori K, Kizawa I, Kato K (1985): The effect of Cimetidine on natural killer activity of peripheral blood lymphocytes of patients with ovarian carcinoma. Jap J Clin Oncol, Vol 15, 377–383.

    CAS  Google Scholar 

  • Kikuchi Y, Oomori K, Kizawa I, Kato K (1986): Augmented natural killer activity in ovarian cancer patients treated with Cimetidine. Eur J Cancer Clin Oncol, Vol 22, 1037–1043.

    Article  PubMed  CAS  Google Scholar 

  • Kirkpatrick CH (1988): Transfer factor. J Allergy Clin Immunol, Vol 81, 803–813.

    Article  PubMed  CAS  Google Scholar 

  • Klefstrom P, Nuortio L, Taskinen E (1986): Postoperative radiation therapy and adjuvant che- moimmunotherapy in breast cancer. Aspects of timing and immune competence. Acta Radiol ( Oncol ), Vol 25, 161–166.

    Google Scholar 

  • Kokoshis PL, Williams DL, Cook JA, Di Luzio NR (1978): Increased resistance to staphylococcus aureus infection and enhancement in serum lysozyme activity by glucan. Science, Vol 199, 1340– 1342.

    Google Scholar 

  • Kook AI, Yakir Y, Trainin N (1975): Isolation and partial chemical characterization of THF, a thymus hormone involved in immune maturation of lymphoid cells. Cell Imm, Vol 19, 151–157.

    Article  CAS  Google Scholar 

  • Kurzrock R, Auber M, Mavligit GM (1987): Cimetidine therapy of Herpex Simplex virus infections in immunocompromised patients. Clin Exp Dermatol, Vol 12, 326–331.

    Article  PubMed  CAS  Google Scholar 

  • Lamm DL, Harris SC, Gittes RF (1977): Bacillus Calmette-Guerin and dinitrochlorobenzene immuno-therapy of chemically induced bladder tumors. Investigative Urology, Vol 14, No 5, 369– 372.

    Google Scholar 

  • Lang RA, Metealf D, Cuthbertson RA, Lyons I, Stanley E, Kelso A, Kannourakis G, Williamson DJ, Klintworth GK, Gonda TJ, Dunn AR (1987): Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage. Cell, Vol 51, 675–686.

    Article  PubMed  CAS  Google Scholar 

  • Le Beau MM, Epstein ND, O’Brien SJO, Nienhuis AW, Yang YC, Clark SC, Rowley JD (1987): The interleukin 3 gene is located on human chromosome 5 and is deleted in myeloid leukemias with a deletion of 5 q. Proc Natl Acad Sci USA, Vol 84, 5912–5917.

    Article  Google Scholar 

  • LeBeau MM, Westbrook CA, Diaz MO, Larson RA, Rowley JD, Gassqn JC, Golde DW, Sherr CJ (1986): Evidence for the involvement of GM-CSF and FMS in the deletion (5q) in myeloid disorders. Science, Vol 231, 984–987.

    Article  PubMed  Google Scholar 

  • Lederer E (1980): Synthetic immunostimulants derived from the bacterial cell wall. J Med Chem, Vol 23, 819–825.

    Article  PubMed  CAS  Google Scholar 

  • Lederer E (1986): New developments in the field of synthetic muramyl peptides, especially as adjuvants for synthetic vaccines. Drugs Exp Clin Res, Vol 12, 429–440.

    PubMed  CAS  Google Scholar 

  • Lifson JD, Benike CJ, Mark DF et al (1984): Human recombinant interleukin-2 partly reconstitutes deficient in-vitro immune responses of lymphocytes from patients with AIDS. Lancet 1 /8379, 698–702.

    Article  PubMed  CAS  Google Scholar 

  • Lomnitzer R, Rabson AR (1987): Depressed 3H-thymidine incorporation by measles infected mononuclear cells can be corrected by treatment with isoprinosine or 5-fluoro-2-deoxyuridine. Clin Exp Immunol, Vol 68, 259–265.

    PubMed  CAS  Google Scholar 

  • Louie E, Borkowsky W, Klesius PH, Haynes TB, Gordon S, Bonk S, Lawrence HS (1987): Treatment of cryptosporidiosis with oral bovine transfer factor. Clin Immunol Immunopathol, Vol 44, 329–334.

    Article  PubMed  CAS  Google Scholar 

  • Low TL, Thurman GB, McAdoo M et al (1979): The chemistry and biology of thymosin I. Isolation, characterization and biological activities of thymosin a and polypeptide b from calf thymus. J Biol Chem, Vol 254, 981–986.

    PubMed  CAS  Google Scholar 

  • Low TLK, Goldstein AL (1980): Thymosin and other thymic hormones and their synthetic ana-logues. In: Chedid L, Miescher PA, Mueller-Eberhard HJ (eds) Immunostimulation. Springer Verlag, Berlin, Heidelberg New York, 129–146.

    Google Scholar 

  • Mackaness GB (1964): The immunologic basis of acquired cellular resistance. J Exp Med, Vol 120, 105–120.

    Article  PubMed  CAS  Google Scholar 

  • Mackaness GB (1971): Resistance to intracellular infection. J Infect Dis, Vol 123, 439–445.

    Article  PubMed  CAS  Google Scholar 

  • Maguire LC, Roszman TL, Lackey S (1985): Failure of Cimetidine as an immunomodulator in cancer patients and normal subjects. South Med J, Vol 78, 1078–1080.

    Article  PubMed  CAS  Google Scholar 

  • Markiewicz K, Malec P, Tchorzewski H (1985): Changes in the interleukin-1 and interleukin-2 generation in duodenal ulcer patients during Cimetidine treatment. Immunol Lett, Vol 10, 19 — 23.

    Article  PubMed  CAS  Google Scholar 

  • Martinez-Pineiro JA, Muntanola P (1977): Nonspecific immunotherapy with BCG vaccine in bladder tumors. Eur Urol, Vol 3, 11–22.

    PubMed  CAS  Google Scholar 

  • Massicot JG, Goldstein RA (1982): Transfer factor. Annals of Allergy, Vol 49, 326–329.

    PubMed  CAS  Google Scholar 

  • Mathe G (1987): Do tuftsin and bestatin constitute a biopharmacological immunoregul atory sys-tem? Cancer Detection and Prevention, Supplement 1, 445–455.

    CAS  Google Scholar 

  • Mathe G, Blazsek I, Canon C, Gil-Delgado M, Misset JL (1986): From experimental to clinical attempts in immunorestoration with bestatin and zinc. Comp Immunol Microbiol Infect Dis, Vol 9, 241–252.

    Article  PubMed  CAS  Google Scholar 

  • Matsumoto K, Ogawa H, Nagase O, Kusama T, Azuma I (1981): Stimulation of nonspecific host resistance to infection induced by muramyldipeptides. Microbiol Immunol, Vol 25 (10), 1047–1058.

    PubMed  CAS  Google Scholar 

  • Mattsson L, Blomgren H, Holmgren B, Jarstrand C (1983): Bestatin treatment for the correction of granulocyte dysfunction in patients with recurrent furunculosis. Infection, Vol 11, 205–207.

    Article  PubMed  CAS  Google Scholar 

  • Mavligit GM (1987): Immunologic effects of Cimetidine: Potential uses. Pharmacotherapy, Vol 7, 120–124.

    Google Scholar 

  • Mayer P, Drews J (1980): The effects of protein-bound polysaccharide from Coriolus versicolor on immunological parameters and experimental infections in mice. Infection, Vol 8, 13–21.

    Article  PubMed  CAS  Google Scholar 

  • Mayer P, Hamberger H, Drews J (1980): Differential effect of ubiquinone Q7 and ubiquinone analogs on macrophage activation and experimental infections in granulocytopenic mice. Infection, Vol 8, No 6, 256–261.

    Article  CAS  Google Scholar 

  • Mayer P, Lam C, Obenaus H, Liehl E, Besemer J (1987): Recombinant human GM-CSF induces leukocytosis and activates peripheral blood polymorphonuclear neutrophils in nonhuman primates. Blood, Vol 70, 206–213.

    PubMed  CAS  Google Scholar 

  • McRneally MF, Maver CM, Alley RD, Kausel HW, Older TM, Foster ED, Lininger L (1979): Regional immunotherapy of lung cancer using intrapleural BCG: summary of a four-year randomized study. In: Muggia F, Rosenzweig M (eds) Lung cancer. Raven Press New York.

    Google Scholar 

  • Mellstedt H, Ahre A, Björkholm M, Holm G, Johansson B, Strander H (1979): Interferon therapy in myelomatosis. Lancet, 245–247.

    Google Scholar 

  • Merigan TC (1988): Human interferon as a therapeutic agent. New Engl J Med, Vol 318, No 22, 1458–1460.

    Article  PubMed  CAS  Google Scholar 

  • Merigan TC, Gallagher JG, Pollard RB, Arvin AM (1981): Short-course human leukocyte inter-feron in treatment of herpes zoster in patients with cancer. Antimicrobial Agents and Chemotherapy, Vol 19, No 1, 193–195.

    PubMed  CAS  Google Scholar 

  • Merluzzi VJ, Badger AM, Kaiser CW, Cooperband SR (1975): In vitro stimulation of murine lymphoid cell cultures by levamisole. Clin Exp Immun, Vol 32, 486–492.

    Google Scholar 

  • Merluzzi VJ, Kaiser CW, Moolten FL, Cooperband SR, Levinsky NG (1975): Stimulation of mouse spleen cells in vitro by levamisole. Fed Proc, Vol 34, 1004.

    Google Scholar 

  • Metealf D (1985): The granulocyte-macrophage colony-stimulating factors. Science, Vol 229, 16– 22.

    Google Scholar 

  • Metealf D (1988): Haemopoietic growth factors. Med J Austral, Vol 148, 516–519.

    Google Scholar 

  • Metealf D, Begley CG, Johnson GR, Nicola NA, Lopez AF, Williamson DJ (1986): Effects of purified bacterially synthetized murine multi-CSF (IL-3) on hematopoiesis in normal adult mice. Blood, Vol 68, 46–57.

    Google Scholar 

  • Meyers JD, Mc Guffin RW, Neiman PE, Singer JW, Thomas ED (1980): Toxicity and efficacy of human leukocyte interferon for treatment of cytomegalovirus pneumonia after marrow trans-plantation. J Infect Dis, Vol 141, No 5, 555–562.

    Article  PubMed  CAS  Google Scholar 

  • Mihich E (1986): Future perspectives for biological response modifiers: a viewpoint. Seminars in Oncology, Vol 13, 234–254.

    PubMed  CAS  Google Scholar 

  • Mihich E, Fefer A (1983): The interferon system. National Cancer Institute Monograph, No 63, 67–104.

    Google Scholar 

  • Mihich E, Fefer A (1983): Thymic factors and hormones. National Cancer Institute Monograph, No 63, 107–137.

    Google Scholar 

  • Miller LL, Spitler LE, Allen RE, Minor DR (1988): A randomized, double-blind, placebo- controlled trial of transfer factor as adjuvant therapy for malignant melanoma. Cancer, Vol 61, 1543–1549.

    Article  PubMed  CAS  Google Scholar 

  • Mitsuyasu RT, Golde DW (1988): Potential role of granulocyte-macrophage colony stimulating factor in patients with HIV infection. Behring Inst Mitt 83, 139–144.

    PubMed  Google Scholar 

  • Miyasaka N, Nakamura T, Russell IJ, Talal N (1984): Interleukin 2 deficiencies in rheumatoid arthritis and systemic lupus erythematosus. Clin Immunol Immunopathol, Vol 31 /1, 109–117.

    Article  PubMed  CAS  Google Scholar 

  • Morgan DA, Ruscetti FW, Gallo RC (1976): Selective in vitro growth of T-lymphocytes from normal human bone-marrows. Science, Vol 193, 1007–1008.

    Article  PubMed  CAS  Google Scholar 

  • Morstyn G, Souza LM, Keech J, Sheridan W, Campbell L, Alton NK, Green M, Metcalf D (1988): Effect of granulocyte colony stimulating factor of neutropenia induced by cytotoxic chemotherapy. Lancet March 26, 667–672.

    Article  Google Scholar 

  • Mulé JJ, Shu S, Schwarz SL, Rosenberg SA (1984): Adoptive immunotherapy of established pulmonary metastases with LAK cells and recombinant interleukin-2. Science, Vol 225, 1487–1489.

    Article  PubMed  Google Scholar 

  • Mustafa AS, Godal T (1987): BCG induced CD4+ cytotoxic T cells from BCG vaccinated healthy subjects: Relation between cytotoxicity and suppression in vitro. Clin Exp Immunol, Vol 69, 255– 262.

    Google Scholar 

  • Nagata S, Tsuchiya M, Asano S, Kaziro Y, Yamazaki T, Yamamoto O, Hirata Y, Kubota N, Oheda M, Nomura H, Ono M (1986): Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor. Nature, Vol 319, 415–418.

    Article  PubMed  CAS  Google Scholar 

  • Nakamura T, Miyasaka N, Pope RM, Talal N, Russel IJ (1983): Immunomodulation by isoprino- sine: Effects on in yitro immune functions of lymphocytes from humans with autoimmune diseases. Clin Exp Immunol, Vol 52, 67–74.

    PubMed  CAS  Google Scholar 

  • Nathan C, Nogueira N, Juangbhanich C, Ellis J, Cohn Z (1979): Activation of macrophages in vivo and in vitro. Correlation between hydrogen peroxide release and killing of trypanosoma cruzi. J Exp Med, Vol 149, 1056–1068.

    Article  PubMed  CAS  Google Scholar 

  • Nathan CF, Silverstein SC, Brukner LH, Cohn ZA (1979): Extracellular cytolysis by activated macrophages and granulocytes. J Exp Med, Vol 149, 100–113.

    Article  PubMed  CAS  Google Scholar 

  • Nicola NA (1987): Why do hemopoietic growth factor receptors interact with each other? Immunology Today, Vol 8 (5), 134–140.

    Article  Google Scholar 

  • Nienhuis AW, Donahue RE, Karlsson J, Clark SC, Agrícola B, Antinoff N, Pierce JE, Turner- P, Anderson WF, Nathan DG (1987): Recombinant human granulocyte-macrophage colony- stimulating factor (GM-CSF) shortens the period of neutropenia after autologous bone marrow transplantation in a primate model. J Clin Invest, Vol 80, 573–577.

    Article  PubMed  CAS  Google Scholar 

  • Nikaido T, Shimizu A, Ishida N, Sabe H, Teshigawara K, Maedam M, Uchiyama T, Yodoi J, Honjo T (1984): Molecular cloning of cDNA encoding human interleukin-2 receptor. Nature, Vol 311, 631–635.

    Article  PubMed  CAS  Google Scholar 

  • Nimer SD, Champlin RE, Golde DW (1988): Serum cholesterol-lowering activity of granulocyte- macrophage colony-stimulating factor. JAMA, Vol 260, 3297–3300.

    Article  PubMed  CAS  Google Scholar 

  • North RJ (1978): The concept of the activated macrophage. The Journal of Immunology, Vol 121, No 3, 806–808.

    PubMed  CAS  Google Scholar 

  • Nyka W (1956): Enhancement of resistance to tuberculosis in mice experimentally infected with Brucella abortus. Am Rev Tuberc, Vol 73, 251.

    PubMed  CAS  Google Scholar 

  • Ogmundsdottir HM, Weir DM (1980): Mechanisms of macrophage activation. Clin Exp Immunol, Vol 40 /2, 223–234.

    PubMed  CAS  Google Scholar 

  • Osada Y, Ohtani T, Une T, Ogawa H, Nomoto K (1982): Enhancement of non-specific resistance to pseudomonas pneumoniae by a synthetic derivative of muramyl dipeptide in immuno-suppressed guinea pigs. J gener Microbiology, Vol 128, 2361–2370.

    CAS  Google Scholar 

  • Osband ME, Shen YJ, Shlesinger M, Brown A, Hamilton D, Cohen E, Lavin P, McCaffrey R (1981): Successful tumour immunotherapy with cimetidine in mice. Lancet, 636–638.

    Google Scholar 

  • Pasino M, Bellone M, Cornaglia P, Tonini GP, Massimo L (1982): Methisoprinol effect on enriched B and T-lymphocyte populations stimulated with phytohemagglutinin. J Immunopharmacol, Vol 4, 101–108.

    Article  PubMed  CAS  Google Scholar 

  • Patrone F, Dallegri F, Pistoia V, Ghio R, Sacchetti C (1985): Restoration of defective EAG- rosetting capacity of cancer patient neutrophils by levamisole. Cancer, Vol 55, 1668–1672.

    Article  PubMed  CAS  Google Scholar 

  • Pestka S (1983): The human interferons — from protein purification and sequence to cloning and expression in bacteria: Before, between and beyond. Arch Biochem Biophys, Vol 221, No 1, 1–37.

    Article  PubMed  CAS  Google Scholar 

  • Pettenati MJ, Le Beau MM, Lemons RS, Shima EA, Kawasaki ES, Larson RA, Sherr CJ, Diaz MO, Rowley JD (1987): Assignment of CSF-1 to 5q33.1: Evidence for clustering of genes regulating hematopoiesis and for their involvement in the deletion of the long arm of chromosome 5 in myeloid disorders. Proc Natl Acad Sci USA, Vol 84, 2970–2974.

    Article  PubMed  CAS  Google Scholar 

  • Pinsky CM, Hirshaut Y, Wanebo HJ, Fortner JG, Mike V, Schottenfeld D, Oettgen HF (1976): Randomized trial of bacillus Calmette-Guérin (percutaneous administration) as surgical adjuvant immunotherapy for patients with stage-II melanoma. Ann New York Acad Sci, Vol 277, 187–194.

    Article  CAS  Google Scholar 

  • Pollard RB (1982): Interferons and interferon inducers: Development of clinical usefulness and therapeutic promise. Drugs, Vol 23, 37–55.

    Article  PubMed  CAS  Google Scholar 

  • Pollard RB, Merigan TC (1978): Experience with clinical applications of interferon and interferon inducers. Pharmac Ther A, Vol 2, 783–811.

    Google Scholar 

  • Presser SE, Blank H (1981): Cimetidine: Adjunct in treatment of tinea capitis. Lancet, 108–109.

    Google Scholar 

  • Priestman TJ (1980): Initial evaluation of human lymphoblastoid interferon in patients with ad-vanced malignant disease. Lancet July 19, 113–118.

    Article  Google Scholar 

  • Priestman TJ (1983): Interferons and cancer therapy. J Pathology, Vol 141, 287–295.

    Article  CAS  Google Scholar 

  • Pullinger EJ (1936): The influence of tuberculosis on the development of Brucella abortus infection. J Hyg Comb 456.

    Google Scholar 

  • Renoux G (1978): Modulation of immunity by levamisole. Pharmacol Ther A2, 397–423.

    CAS  Google Scholar 

  • Renoux G, Renoux M (1971): Effet immunostimulant d’un imidothiazole dans l’immunisation des souris contre l’infection par Brucella abortus. CR Acad Sci, Vol 272 D, 349–350.

    Google Scholar 

  • Renoux G, Renoux M (1972): Antigenic competition and non specific immunity after a rickettsial infection in mice: Restoration of antibacterial immunity by phenyl-imidothiazole treatment. The Journal of Immunology, Vol 109, 761–765.

    PubMed  CAS  Google Scholar 

  • Renoux G, Renoux M (1972): Restauration par le phénylimidothiazole de la réponse immunolo- gique des souris âgées. CR Acad Sci, Vol 274D, 3034–3035.

    CAS  Google Scholar 

  • Renoux G, Renoux M (1979): Immunopotentiation and anabolism induced by sodium diethyldi- thiocarbamate. J Immunopharmacol, Vol 1 (2), 247–267.

    Article  PubMed  CAS  Google Scholar 

  • Renoux G, Renoux M, Teller MN, McMahon S, Guillaume JM (1976): Potentiation of T-cell mediated immunity by levamisole. Clin Exp Immunol, Vol 25, 288–296.

    PubMed  CAS  Google Scholar 

  • Renoux G, Touraine J-L, Renoux M (1980): Induction of differentiation of human null cells into T lymphocytes under the influence of serum of mice treated with sodium diethyldithiocarbamate. J Immunopharm, Vol 2 (1), 49–59.

    Article  CAS  Google Scholar 

  • Rey A, Cupissol D, Thierry C, Esteve C, Serrou B (1983): Modulation of human lymphocyte functions by isoprinosine. Int J Immunopharm, Vol 5, No 1, 99 — 103.

    Article  CAS  Google Scholar 

  • Richtsmeier WJ, Eisele D (1986): In vivo anergy reversal with cimetidine in patients with cancer. Arch Otolaryngol Head Neck Surg, Vol 112, 1074–1077.

    PubMed  CAS  Google Scholar 

  • Ridgway D, Borzy MS, Bagby GC (1988): Granulocyte macrophage colony-stimulating activity production by cultured human thymic non-lymphoid cells is regulated by endogenous interleukin- 1. Blood, Vol 72, 1230–1236.

    PubMed  CAS  Google Scholar 

  • Robb RJ (1984): Interleukin 2: the molecule and its function. Immunology Today, Vol 5, No 7, 203–209.

    Article  CAS  Google Scholar 

  • Rosenberg SA (1988): Immunotherapy of patients with advanced cancer using interleukin-2 alone or in combination with lymphokine activated killer cells. Important Advances in Oncology, 1988, 217–257.

    Google Scholar 

  • Rosenberg SA (1988): The development of new immunotherapies for the treatment of cancer using interleukin-2. A review. Annals of Surgery, Vol 208, 121–135.

    Article  PubMed  CAS  Google Scholar 

  • Rosenberg SA, Grimm EA, McGrogan M, Doyle M et al (1984): Biological activity of recombinant human interleukin-2 produced in Escherichia coli. Science, Vol 223, 1412–1415.

    Article  PubMed  CAS  Google Scholar 

  • Rosenthal SR (1988): Surgery, recall antigens, immunity, and bacillus Calmette-Guerin vaccination. Am J Surg, Vol 156, 1–3.

    Article  PubMed  CAS  Google Scholar 

  • Rossi GA, Felletti R, Balbi B, Sacco O, Cosulich E, Risso A, Melioli’G, Ravazzoni C (1987): Symptomatic treatment of recurrent malignant pleural effusions with intrapleurally administered corynebacterium parvum. Clinical response is not associated with evidence of enhancement of local cellular-mediated immunity. Am Rev Respir Dis, Vol 135, 885–890.

    Google Scholar 

  • Rothstein G, Rhondeau SM, Peters CA, Christensen RD, Gillis S (1988): Stimulation of neutrophil production in CSF-l-responsive clones. Blood, Vol 72, 898–902.

    PubMed  CAS  Google Scholar 

  • Ruch W, Cooper PH, Baggiolini M (1983): Assay of H202 production by macrophages and neutrophils with homovanillic acid and horseradish peroxidase. J Immunol Methods, Vol 63, 347– 357.

    Google Scholar 

  • Ruco LP, Meltzer MS (1978): Macrophage activation for tumor cytotoxicity: tumoricidal activity by macrophages from C3H/HeJ mice requires at least two activation stimuli. Cell Immunol, Vol 41, 35–51.

    Article  PubMed  CAS  Google Scholar 

  • Ruscetti FW (1984): Biology of interleukin-2. Surv Immunol Res (Switzerland), Vol 3/2–3, 122– 126.

    Google Scholar 

  • Ruscetti FW (1988): Interleukin 2 receptor: Two distinct proteins bind interleukin 2. The Year in Immunology, Vol 3, 129–137.

    PubMed  CAS  Google Scholar 

  • Saiki I, Milas L, Hunter N, Fidler IJ (1986): Treatment of experimental lung metastasis with local thoracic irradiation followed by systemic macrophage activation with liposomes containing muramyl tripeptide. Cancer Research, Vol 46, 4966–4970.

    PubMed  CAS  Google Scholar 

  • Schumann G (1986): Antiviral and antitumor effects of liposome-entrapped MTP-PE, a lipophilic muramylpeptide. In Seidl PH, Schleifer KH (eds) Biological Properties of Peptidoglycan, Walter de Gruyter, Berlin, New York, 255–260.

    Google Scholar 

  • Schumann G (1987): Biological activities of a lipophilic muramylpeptide (MTP-PE). In Azuma I, Jolles G (eds) Immunostimulants: Now and Tomorrow, Springer, New York, 71–77.

    Google Scholar 

  • Schumann G, van Hoogevest P, Fankhauser P, Probst A, Peil A, Court M, Schaffner J-C, Fischer M, Skripsky T, Graepel P (19B8): Comparison of free and liposomal MTP-PE: Pharmacological, toxicological and pharmacokinetic aspects. UCLA Symposium “Liposomes in the Therapy of Infectious Diseases and Cancer”, 1–13.

    Google Scholar 

  • Scott GM, Philipotts RJ, Wallace J, Secher DS, Cantell K, Tyrrell DAJ (1982): Purified interferon as protection against rhinovirus infection. Brit Med J, Vol 284, 1822–1825.

    Article  CAS  Google Scholar 

  • Scott GM, Tyrrell DAJ (1980): Interferon: Therapeutic fact or fiction for the ’80s? Brit Med J, Vol 280, 1558–1562.

    Article  PubMed  CAS  Google Scholar 

  • Scullard GH, Pollard RB, Smith JL, Sacks SL, Gregory PB, Robinson WS, Merigan TC (1981): Antiviral treatment of chronic hepatitis B virus infection. I. Changes in viral markers with interferon combined with adenine arabinoside. J Infect Dis, Vol 143, No 6, 772–783.

    Article  PubMed  CAS  Google Scholar 

  • Shah I, Band J, Rudnick S, Lerner AM (1982): Pharmacokinetics and tolerance of intravenous recombinant alpha2 interferon (a2 IFN) in patients with lympho-proliferative malignancies. Clin Res, Vol 30, No 4, 732 A.

    Google Scholar 

  • Shalaby MR, Weck PK (1983): Bacteria-derived human leukocyte interferons alter in vitro humoral and cellular immune responses. Cellular Immunology, Vol 82, 269–281.

    Article  PubMed  CAS  Google Scholar 

  • Sher R, Wadee AA, Joffe M, Kok SH, Imkamp FMJH, Simson IW (1981): The in vivo and in vitro effects of levamisole in patients with lepromatous leprosy. Intern J Leprosy, Vol 49, No 2, 159–166.

    CAS  Google Scholar 

  • Sieff CA (1987): Hematopoietic growth factors. J Clin Invest, Vol 79, No 6, 1549–1557.

    Article  PubMed  CAS  Google Scholar 

  • Silvennoinen-Kassinen S, Karttunen R, Tiilikainen A, Huttunen K (1987): Isoprinosine enhances PHA responses and has potential effect on natural killer cell (NK) activity of uremic patients in vitro. Nephron, Vol 46, 243–246.

    Article  PubMed  CAS  Google Scholar 

  • Simmers RN, Weber LM, Shannon F, Garson MO, Wong G, Vadas MA, Sutherland GR (1987): Localization of the G-CSF gene on chromosome 17 proximal to the breakpoint in the t(15;17) in acute promyelocytic leukemia. Blood, Vol 70, 330–332.

    PubMed  CAS  Google Scholar 

  • Simon MR, Salberg DJ, Silva J, Ganji S, Desai S, Muller BF, Palutke M (1981): Atypical mycobacterium infection treated with dialyzable leukocyte extracts: evidence for antigenic specificity. Clin Immunol Immunopath, Vol 20, 123–128.

    Article  CAS  Google Scholar 

  • Singh MM, Kumar P, Malaviya AN, Kumar R (1981): Levamisole as an adjunct in the treatment of pulmonary tuberculosis. Am Rev Respir Dis, Vol 123 /3, 277–279.

    PubMed  CAS  Google Scholar 

  • Smith KA (1984): Interleukin 2. Ann Rev Immunol, Vol 2, 319–333.

    Article  CAS  Google Scholar 

  • Smith R, Esa A (1982): In vitro effect of murine-derived transfer factor on Salmonella-specific rosette formation. Infection and Immunity, Vol 38, 588–591.

    PubMed  CAS  Google Scholar 

  • Socinski MA, Elias A, Schnipper L, Cannistra SA, Antman KH, Griffin JD (1988): Granulocyte- macrophage colony stimulating factor expands the circulating haemopoietic progenitor cell com-partment in man. Lancet, May 28, 1194–1198.

    Article  Google Scholar 

  • Solbach W, Rollinghoff M, Wagner H (1983): Die Rolle von Interleukin-2 bei Aktivierung von zytotoxischen T-Lymphozyten. Klin Wschr, Vol 61 /2, 67–75.

    Article  PubMed  CAS  Google Scholar 

  • Solo way MS (1988): Introduction and overview of intravesical therapy for superficial bladder cancer. Urology, Vol 31, 5 — 16.

    Google Scholar 

  • Sone S, Lopez-Berestein G, Fidler IJ (1986): Potentiation of direct antitumor cytotoxicity and production of tumor cytolytic factors in human blood monocytes by human recombinant interferon-gamma and muramyl dipeptide derivatives. Cancer Immunol Immunother, Vol 21, 93–99.

    Article  PubMed  CAS  Google Scholar 

  • Sone S, Tandon P, Utsugi T, Ogawara M, Shimizu E, Nii A, Ogura T (1986): Synergism of recombinant human interferon gamma with liposome-encapsulated muramyl tripeptide in activa-tion of the tumoricidal properties of human monocytes. Int J Cancer, Vol 38, 495–500.

    Article  PubMed  CAS  Google Scholar 

  • Sone S, Tsubura E (1982): Human alveolar macrophages: Potentiation of their tumoricidal activity by liposome-encapsulated muramyl dipeptide. The Journal of Immunology, Vol 129, No 3,1313- 1317.

    Google Scholar 

  • Sone S, Utsugi T, Tandon P, Ogawara M (1986): A dried preparation of liposomes containing muramyl tripeptide phosphatidylethanolamine as a potent activator of human blood monocytes to the antitumor state. Cancer Immunol Immunother, Vol 22, 191–196.

    Article  PubMed  CAS  Google Scholar 

  • Souza LM, Boone TC, Gabrilove J, Lai PH, Zsebo KM, Murdock DC, Chazin VR, Bruszewski J, Lu H, Chen KK, Barendt J, Platzer E, Moore MAS, Mertelsmann R, Welte K (1986): Recombi-nant human granulocyte colony-stimulating factor: Effects on normal and leukemic myeloid cells. Science, Vol 232, 61–65.

    Article  PubMed  CAS  Google Scholar 

  • Steele RW, Myers MG, Vincent MM (1980): Transfer factor for the prevention of varicella-zoster infection in childhood leukemia. New Engl J Med, Vol 303, No 7, 355–359.

    Article  PubMed  CAS  Google Scholar 

  • Suter E (1956): Interaction between phagocytes and pathogenic microorganisms. Bacteriol Rev, Vol 20, 94–132.

    PubMed  CAS  Google Scholar 

  • Symoens J, Decree Wf, Van Bever M, Janssen PAJ (1979): Levamisole. In: Goldberg M (ed) Pharmacological and biochemical properties of drug substances. Vol 2, American Pharmaceutical Association, Washington, DC, 407–464.

    Google Scholar 

  • Symoens J, Rosenthal M, De Brabander M, Goldstein A (1980): Immunoregulation with levami-sole. In: Chedid L et al. (eds) Immuno-stimulation. Springer, Heidelberg.

    Google Scholar 

  • Tandon P, Utsugi T, Sone S (1986): Lack of production of interleukin 1 by human blood monocytes activated to the antitumor state by liposome-encapsulated muramyl tripeptide. Cancer Res, Vol 46, 5039–5044.

    PubMed  CAS  Google Scholar 

  • Taniguchi T, Matsui H, Fujita T, Takaoka C, Kashima N, Yoshimoto R, Hamuro J (1983): Structure and expression of a cloned cDNA for human interleukin-2. Nature, Vol 302, 305–310.

    Article  PubMed  CAS  Google Scholar 

  • Thatcher N, Mene A, Banerjee SS, Craig P, Gleave N, Orton C (1986): Randomized study of corynebacterium parvum adjuvant therapy following surgery for (stage II) malignant melanoma. Brit J Surg, Vol 73, Nr 2, 111–115.

    Article  PubMed  CAS  Google Scholar 

  • Thienpont D, Vanparus OFJ, Raymaekers AHM, Vandenberk J, Demoen PJA, Allewun FTN, Marsboom RPH, Niemegeers CJE, Schellekens KHL, Janssen PAJ (1966): Tetramisole (R8299), a new potent broad spectrum anthelminthic. Nature, Vol 209, 1084–1086.

    Article  PubMed  CAS  Google Scholar 

  • Touraine J-L, Hadden JW, Touraine F (1980): Isoprinosine-induced T-cell differentiation and T- cell suppressor activity in humans. Current Chemotherapy of Infect Dis, Vol 1, 1735–1736.

    Google Scholar 

  • Toy JL (1983): The interferons. Clin Exp Immunol, Vol 54, 1–13.

    PubMed  CAS  Google Scholar 

  • Ts’o POP, Alderfer JL, Levy J, Marshall LW, O’Malley J, Horoszewicz JS, Carter WA (1976): An integrated and comparative study of the antiviral effects and other biological properties of the polyinosinic acid-poly cy tidy lie acid and its mismatched analogues. Molecular Pharmacology, Vol 12, 299–312.

    PubMed  Google Scholar 

  • Tsang KY, Donnelly RP, Galbraith GM, Fudenberg HH (1986): Isoprinosine effects on interleukin- 1 production in acquired immune deficiency syndrome (AIDS). Int J Immunopharm, Vol 8, 437– 441.

    Google Scholar 

  • Tsang KY, Pan JF, Swanger DL, Fudenberg HH (1985): In vitro restoration of immune responses in aging humans by isoprinosine. Int J Immunopharm, Vol 7, 199–206.

    Article  CAS  Google Scholar 

  • Tsang P, Lew F, O’Brien G, Selikoff IJ, Bekesi JG (1985): Immunopotentiation Sf impaired lymphocyte functions in vitro by isoprinosine in prodromal subjects and AIDS patients. Int J Immunopharm, Vol 7, 511–514.

    Article  CAS  Google Scholar 

  • Tsang PH, Sci Y, Bekesi JG (1987): Isoprinosine-induced modulation of T-helper-cell subsets and antigen-presenting monocytes resulted in improvement of T- and B-lymphocyte functions, in vitro in ARC and AIDS patients. Clin Immunol Immunopath, Vol 45, 166–176.

    Google Scholar 

  • Umezawa H, Aoyagi T, Suda H, Hamada M, Takeuchi T (1976): Bestatin, an inhibitor of ami- nopeptidase B produced by actinomycetes. J Antibiot, Vol 29, 97–99.

    PubMed  CAS  Google Scholar 

  • Vadhan-Raj S, Keating M, LeMaistre A, Hittelman WN, McCredie K, Trujillo JM, Broxmeyer HE, Henney C, Gutterman JU (1987): Effects of recombinant human granulocyte-macrophage colony-stimulating factor in patients with myelodysplastic syndromes. New Engl J Med, Vol 317, 1545–1552.

    Article  PubMed  CAS  Google Scholar 

  • Vaith P, Maas D, Feigl D, Hauke G, Lang B, Oepke G, Stierle HE, Bross KJ, Andreesen R, Gross G (1985): In vitro and in vivo studies with interleukin 2 (IL-2) and various immunostimulants in a patient with AIDS. Immun Infekt, Vol 13, 51–63.

    PubMed  CAS  Google Scholar 

  • Van Haver H, Lissoir F, Droissart C, Ketelaer P, Van Hees J, Theys P, Vervliet G, Claeys H, Gautama K, Vermylen C (1986): Transfer factor therapy in multiple sclerosis: A three-year prospective double-blind clinical trial. Neurology, Vol 36, 1399–1402.

    PubMed  Google Scholar 

  • Van der Spruy S, Levy DW, Levin W (1980): Cimetidine in the treatment of herpes virus infections. S Afr Med J, Vol 58 /3, 112–116.

    Google Scholar 

  • Van Eygen M, Znamensky PY, Heck E, Raymaekers I (1976): Levamisole in prevention of recurrent upper–respiratory-tract infections in children. Lancet II, 382 - 385.

    Google Scholar 

  • Veys EM, Mielants H, Symoens J, Vetter G, Huskisson EC, Scott J, Felix-Davies DD, Wilkinson B, Rosenthal M, Vischer TL, Gerster JC (1978): Multicentre study group report: A multicentre randomized double-blind study comparing two dosages of levamisole in rheumatoid arthritis. J Rheumatol Suppl 4, 5–10.

    Google Scholar 

  • Veys EM, Mielants H, Verbruggen G, Dhondt E, Goetnais L, Cherouthre L, Buelens H (1981): Levamisole as basic treatment of rheumatoid arthritis: Long-term evaluation. J Rheumatol, Vol 8, 44–56.

    Google Scholar 

  • Veys EM, Symoens J (1981): Immunopharmacologic therapy of connective tissue diseases. In: Hadden J, Chedid L, Mullen P, Spreafico F (eds): Advances in immuno-pharmacology. Vol 1, Pergamon Press, Oxford, 140–147.

    Google Scholar 

  • Wagner G, Knapp W, Gitsch E, Seiander S (1987): Transfer factor for adjuvant immunotherapy in cervical cancer. Cancer Detection and Prevention, Supplement 1, 373–376.

    CAS  Google Scholar 

  • Wara DW, Goldstein AL, Doyle N et al (1975): Thymosin activity in patients with cellular immunodeficiency. New Engl J Med, Vol 292, 70–74.

    Article  PubMed  CAS  Google Scholar 

  • Warren MK, Ralph P (1986): Macrophage growth factor CSF-1 stimulates human monocyte production of interferon, tumor necrosis factor, and colony stimulating activity. The Journal of Immunology, Vol 137, 2281–2285.

    PubMed  CAS  Google Scholar 

  • Waymack JP, Alexander JW (1986): Immunostimulation by TP-5 in immunocompromised patients and animals - current status of investigation. Comp Immunol Microbiol Infect Dis, Vol 9, 225– 232.

    Google Scholar 

  • Weir DM, Blackwell CC (1983): Interaction of bacteria with the immune system. J Clin Lab Immunol, Vol 10, 1–12.

    PubMed  CAS  Google Scholar 

  • Weisbart RH, Golde DW, Clark SC, Wong GG, Gasson JC (1985): Human granulocyte-macro-phage colony-stimulating factor is a neutrophil activator. Nature, Vol 314, 361–363.

    Article  PubMed  CAS  Google Scholar 

  • Welte K, Bonilla MA, Gillio AP, Boone TC, Potter GK, Gabrilove JL, Moore MAS, O’Reilly RJ, Souza LM (1987): Recombinant human granulocyte colony-stimulating factor. Effects on hematopoiesis in normal and cyclophosphamide-treated primates. J Exp Med, Vol 165, 941–948.

    Article  PubMed  CAS  Google Scholar 

  • Welte K, Ciobanu N, Moore MAS, Gulati S, O’Reilly RJ, Mertelsmann R (1984): Defective interleukin 2 production in patients after bone marrow transplantation and in vitro restoration of defective T lymphocyte proliferation by highly purified interleukin 2. Blood, Vol 64, No 2, 380– 385.

    Google Scholar 

  • 82nd WHO Expert Committee on biological standardization (1983): Standardization of interferons. World Health Organization. Technical Report Series, No 687, 35–60.

    Google Scholar 

  • Werb Z, Chin JR (1983): Apoprotein E is synthesized and secreted by resident and thioglycollate- elicited macrophages but not by pyran copolymer - or bacillus Calmette-Guerin - activated macrophages. J Exp Med, Vol 138, 1272 - 1293.

    Google Scholar 

  • Wiedemann D, Wiedermannova D, Lokaj J (1987): Immunorestoration in children with recurrent respiratory infections treated with isoprinosine. Int J Immunopharm, Vol 9, 947–949.

    Article  Google Scholar 

  • Wilhams DL, Di Luzio NR (1980): Glucan-induced modification of murine viral hepatitis. Science, Vol 208, 67–69.

    Article  Google Scholar 

  • Wilson GB, Metealf JF, Fudenberg HH (1982): Treatment of mycobacterium fortuitum pulmonary infection with transfer factor (TF): New methodology for evaluating TF potency and predicting clinical response. Clin Immunol Immunopath, Vol 23, 478–491.

    Article  CAS  Google Scholar 

  • Wing EJ, Gardner ID, Ryning FW, Remington JS (1977): Dissociation of effector functions in populations of activated macrophages. Nature, Vol 268, 642–644.

    Article  PubMed  CAS  Google Scholar 

  • Wiranowska-Stewart M, Hadden JW (1986): Effects of isoprinosine and NPT15392 on interleukin- 2 (IL-2) production. Int J Immunopharmacol, Vol 8, 63–69.

    Article  PubMed  CAS  Google Scholar 

  • Wolinsky JS, Dan PC, Buimovici-Klein E, Mednick J, Berg BO, Lang PB, Cooper LZ (1979): Progressive rubella panencephalitis: Immunovirological studies and results of isoprinosine therapy. Clin Exp Immunol, Vol 35, 397–404.

    PubMed  CAS  Google Scholar 

  • Wong GG, Clark SC (1988): Multiple actions of interleukin 6 within a cytokine network. Immunology Today, Vol 9, No 5, 137–139.

    Article  PubMed  CAS  Google Scholar 

  • Wong GG, Witek JS, Temple PA, Wilkens KM, Leary AC, Luxenberg DP, Jones SS, Brown EL, Kay RM, Orr EC, Shoemaker C, Golde DW, Kaufmann RJ, Hewick RM, Wang EA, Clark SC (1985): Human GM-CSF: Molecular cloning of the complementary DNA and purification of the natural and recombinant proteins. Science, Vol 228, 810–815.

    Article  PubMed  CAS  Google Scholar 

  • Woodruff MFA (1986): The cytolytic and regulatory role of natural killer cells in experimental neoplasia. Biochimica et Biophysica Acta, Vol 865, 43–57.

    PubMed  CAS  Google Scholar 

  • Woods WA, Fliegelmann MJ, Chirigos MA (1975): Effect of levamisole (NSC-177023) on DNA synthesis by lymphocytes from immunosuppressed C57BL mice. Cancer Chemother Rep, Vol 59, 531–536.

    PubMed  Google Scholar 

  • Yang YC, Ciarletta AB, Temple PA, Chung MP, Kovacic S, Witek-Giannotti JS, Leary AC, Kriz R, Donahue RE, Wong GG, Clark SC (1986): Human IL-3 (multi-CSF): Identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3. Cell, Vol 47, 3–10.

    Google Scholar 

  • Zidek Z, Capkova J, Boubelik M, Masek K (1983): Opposite effects of the synthetic immunomodu- lator, muramyl dipeptide, on rejection of mouse skin allografts. Eur J Immunol, Vol 13, 859–861.

    Article  PubMed  CAS  Google Scholar 

  • Zsebo KM, Yuschenkoff VN, Schiffer S, Chang D, McCall E, Dinarello CA, Brown MA, Altrock B, Bagby GC (1988): Vascular endothelial cells and granulopoiesis: Interleukin-2 stimulates release of G-CSF and GM-CSF. Blood, Vol 71, 99–103.

    PubMed  CAS  Google Scholar 

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Drews, J. (1990). Immunostimulation. In: Immunopharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75561-3_6

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