Skip to main content
SpringerLink
Log in

Non-Hodgkin’s Lymphomas in Patients with AIDS

  • Conference paper
The Management of Non-Hodgkin’s Lymphomas in Europe

Part of the book series: ESO Intercity Report ((ESO INTERCITY))

  • 43 Accesses

Abstract

The increased incidence of malignancies associated with AIDS has been the subject of several reports in the North American literature: besides Kaposi’s sarcoma and other tumours, such as squamous carcinoma of the tongue and cloacogenic carcinoma of the anorectum [1–22], malignant lymphomas have been demonstrated to be one of the major problems among the neoplastic complications of AIDS [12–24]. According to the North American experience, non-Hodgkin’s lymphomas in patients with AIDS or AIDS-related clinical conditions present at an advanced stage in which lesions are concentrated in extranodal and often unusual locations, notably the CNS. Disease confined to the lymph nodes is uncommon. These lymphomas are predominantly high-grade B-cell neoplasms classified as immunoblastic and Burkitt’s-like lymphomas. A variety of severe opportunistic infections and Kaposi’s sarcoma affect these patients. At the same time, the association with AIDS is strengthened by the regular demonstration of reversed ratios of helper (T4+) and suppressor (T8+) lymphocytes in the peripheral blood and by the presence of antibodies to human immune deficiency virus (HIV) [22]. The prognosis is dismal: response to chemotherapy does not positively affect median survival. Mortality rates analysed by histological grade are higher than the currently reported rates for comparable patient populations [18].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Safai B, Koziner B: Malignant neoplasms in AIDS. In: De Vita VT Jr, Hellmann S, Rosenberg SA (eds) AIDS — Etiology, Diagnosis, Treatment and Prevention. Lippincott, Philadelphia 1985 pp 213–222

    Google Scholar 

  2. Biggar RJ, Horm J, Lubin JH et al: Cancer trends in a population at risk of acquired immune-deficiency syndrome. JNCI 1985 (4):793–794

    Google Scholar 

  3. Hymes KB, Green JB, Marcus A et al: Kaposi sarcoma in homosexual men — a report of eight cases. Lancet 1981 (2):598–600

    Article  PubMed  CAS  Google Scholar 

  4. Centers of Disease Control Task Force on Kaposi’s Sarcoma and Opportunistic Infections. Epidemiologic aspects of the current outbreak of Kaposi’s sarcoma and opportunistic infections. N Engl J Med 1982 (306):248–252

    Google Scholar 

  5. Gottlieb GJ, Ragaz A, Vogel JV et al: A preliminary communication on extensively disseminated Kaposi’s sarcoma in young homosexual men. Am J Dermatopathol 1981 (3):111–114

    Article  PubMed  CAS  Google Scholar 

  6. Safai B: Kaposi’s sarcoma and other neoplasms in acquired immunodeficiency syndrome. In: Galin JI, Fauci AS (eds) Advances in Host Defense Mechanisms. Raven Press, New York 1985 pp 59–73

    Google Scholar 

  7. Myskowsky PL, Romano JF, Safai B: Kaposi’s sarcoma in young homosexual men. Cutis 1983 (29):31–34

    Google Scholar 

  8. Friedman-Kien AE, Laubenstein LJ, Raubenstein P et al: Disseminated Kaposi’s sarcoma in homosexual men. Ann Intern Med 1982 (96):693–697

    PubMed  CAS  Google Scholar 

  9. Groopman JE: Neoplasms in the acquired immunodeficiency syndrome: the multidisciplinary approach to treatment. Semin Oncol 1987 (14 suppl 3):1–6

    PubMed  CAS  Google Scholar 

  10. Peters RK, Mack TM: Patterns of anal carcinoma by gender and marital status in Los Angeles County. Br J Cancer 1983 (48):629–636

    Article  PubMed  CAS  Google Scholar 

  11. Cooper MS, Patchefsky AS, Marks G: Cloacogenic carcinoma of the anorectum in homosexual men: an observation of four cases. Dis Colon Rectum 1979 (2):557

    Article  Google Scholar 

  12. Ahmed T, Wormser GP, Stahl RE et al: Malignant lymphomas in a population at risk for acquired immunodeficiency syndrome. Cancer 1987 (60):719–723

    Article  PubMed  CAS  Google Scholar 

  13. Ziegler JL, Miner RC, Rosenbaum E et al: Outbreak of Burkitt’s lymphoma in homosexual men. Lancet 1982 (2):631–633

    Article  PubMed  CAS  Google Scholar 

  14. Diffuse undifferentiated non-Hodgkin’s lymphoma among homosexual males in the United States. Morbid Mortal Weekly Rep 1982:277–279

    Google Scholar 

  15. Ioachim HL, Hellmann GC: Lymphomas associated with the acquired immunodeficiency syndrome (AIDS): a study of 35 cases. Cancer Detect Prev 1987 (suppl 1):557–565

    CAS  Google Scholar 

  16. Jaffe ES, Clark J, Steis R et al: Lymph node pathology of HTLV-associated neoplasm. Cancer Res 1985 (45, suppl) :4662S–4664S

    PubMed  CAS  Google Scholar 

  17. Shoeppel S, Hoppe R, Abrams D et al: Hodgkin’s disease (HD) in homosexual men: the San Francisco Bay Area experience. Presented at the Annual Meeting of the American Society of Clinical Oncology. Houston TX, 1986

    Google Scholar 

  18. Ziegler JL, Beckstead AJ, Volberding PA et al: Non-Hodgkin’s lymphoma in 90 homosexual men. N Engl J Med 1984 (311):565–570

    Article  PubMed  CAS  Google Scholar 

  19. Gill P, Levine AM, Rarick M et al: Malignant non-Hodgkin’s lymphomas (NHL) in patients with HIV infection. Presented at the Third International Conference on Malignant Lymphoma. Lugano, Switzerland, 1987

    Google Scholar 

  20. Knowles DM, Chamulak G, Subar M et al: Clinical, morphologic, phenotypic and molecular genetic analysis of AIDS/ARC-associated malignant lymphoid neoplasia. Presented at the Third International Conference on Malignant Lymphoma. Lugano, Switzerland, 1987

    Google Scholar 

  21. Kaplan LD, Volberding PA, Abrams DI: Update on AIDS-associated non-Hodgkin’s lymphoma (NHL) in San Francisco. Presented at the Third International Conference on AIDS. Washington DC, 1987

    Google Scholar 

  22. Levine AM: Non-Hodgkin’s lymphomas and other malignancies in the acquired immune-deficiency syndrome. Semin Oncol 1987 (14 suppl 3):34–39

    PubMed  CAS  Google Scholar 

  23. loachim HL, Weinstein MA, Robbins RD et al: Primary anorectal lymphoma. A new manifestation of the acquired immune deficiency syndrome (AIDS). Cancer 1987 (60):1449–1453

    Article  PubMed  CAS  Google Scholar 

  24. Burkes RL, Meyer PR, Gill PS et al: Rectal lymphoma in homosexual men. Arch Intern Med 1986 (146):913–915

    Article  PubMed  CAS  Google Scholar 

  25. Raphael M, Tulliez M, Bellefoth S et al: Les lymphomes et le SIDA. Ann Pathol 1986 (6):278–281

    PubMed  CAS  Google Scholar 

  26. Lev HJ, Schneider J, Hardmeier T et al: Kaposi’s sarcoma and malignant lymphoma in AIDS. Virchows Arch 1984 (403):205–212

    Article  Google Scholar 

  27. Payan MJ, Gambarelli D, Routy JP et al: Primary lymphoma of the brain associated with AIDS. Acta Neuropathol, Berlin 1984 (64):78–80

    Article  CAS  Google Scholar 

  28. Casadei GP, Gambacorta M: A clinico-pathological study of seven cases of primary high-grade malignant non-Hodgkin’s lymphoma of the central nervous system. Tumori 1985 (71):501–507

    PubMed  CAS  Google Scholar 

  29. Skinhoj P, Ersboll J, Nissen NI: Human immunodeficiency virus (HIV) associated non-Hodgkin’s lymphomas in Denmark: report of three cases. Eur J Haematol 1987 (39):71–74

    Article  PubMed  CAS  Google Scholar 

  30. Anonymous: Case definition of AIDS revised. Morbid Mortal Weekly Rep 1985 (34):373–375

    Google Scholar 

  31. Kaplan EL, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958 (53):457–481

    Article  Google Scholar 

  32. Anonymous: Aggiomamento sull’AIDS al 30.8.87. Boll Epidemiol Naz 1987 (9):1–5

    Google Scholar 

  33. Anonymous: Update: acquired immunodeficiency syndrome — United States. Morbid Mortal Weekly Rep 1987(36):522–525

    Google Scholar 

  34. Zagonel V, Tirelli U, Vaccher E et al: Clinical and laboratory findings at presentation in Persistent Generalized Lymphadenopathy vs Malignant Lymphoma. Cancer Detect Prevent 1988 (12):225–229

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Italian Cooperative Group for AIDS-related Tumours, Italy

    U. Tirelli, E. Vaccher, D. Errante, I. Crosato, G. Rezza, A. Lazzarin, R. Foà, S. Pileri, A. Carbone, G. Ambrosini, A. Andriani, M. Barberis, M. Barbui, C. Bernasconi, I. Bianco Silvestroni, A. Borri, G. Bottinelli, G. Broccia, P. L. Bullian, A. Cajozzo, A. Cargnel, P. Cazzaniga, F. Chiodo, T. Chisesi, M. Clerici, P. Costigliola, P. Crocchiolo, F. De Lalla, M. Della Santa, P. Dessalvi, F. Fiaccadori, F. Figoli, M. Florentino, M. Franchi, P. L. Garavelli, F. Gherlinzoni, F. Gianelli, M. G. Giudici, C. Guglielmi, G. Lambertenghi Deliliers, F. Lanza, F. Lombardi, G. Luzi, R. Luzzati, A. Malfitano, C. Malleo, F. Mandelli, M. Marangolo, A. Maringos, G. Martignoni, D. Milo, V. Montesarchio, L. Ortona, G. Palmieri, E. A. Parrinello, N. Piersantelli, G. Pizzoccaro, C. Pristerà, F. Puppo, A. Quaglino, E. Raise, A. Riccardi, E. Ricchi, G. Rizzardini, M. Rizzi, F. Rizzo, A. M. Rosci, G. Rossi, S. Sabbatani, G. Saliva, G. Salvi, S. Saracchini, G. Scalise, A. Scanni, A. Sinicco, R. Sorio, V. A. Squadrini, R. Stellini, V. Stracca Pansa, E. Sulis, A. Surbone, A. Terragna, A. Tognetti, A. Vaglia, R. Zagni, V. Zagonel, F. Gavosto & S. Monfardini

Authors
  1. U. Tirelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Vaccher
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. Errante
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. I. Crosato
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G. Rezza
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. Lazzarin
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. R. Foà
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. S. Pileri
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. A. Carbone
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. G. Ambrosini
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. A. Andriani
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. M. Barberis
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. M. Barbui
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. C. Bernasconi
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. I. Bianco Silvestroni
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. A. Borri
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. G. Bottinelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  18. G. Broccia
    View author publications

    You can also search for this author in PubMed Google Scholar

  19. P. L. Bullian
    View author publications

    You can also search for this author in PubMed Google Scholar

  20. A. Cajozzo
    View author publications

    You can also search for this author in PubMed Google Scholar

  21. A. Cargnel
    View author publications

    You can also search for this author in PubMed Google Scholar

  22. P. Cazzaniga
    View author publications

    You can also search for this author in PubMed Google Scholar

  23. F. Chiodo
    View author publications

    You can also search for this author in PubMed Google Scholar

  24. T. Chisesi
    View author publications

    You can also search for this author in PubMed Google Scholar

  25. M. Clerici
    View author publications

    You can also search for this author in PubMed Google Scholar

  26. P. Costigliola
    View author publications

    You can also search for this author in PubMed Google Scholar

  27. P. Crocchiolo
    View author publications

    You can also search for this author in PubMed Google Scholar

  28. F. De Lalla
    View author publications

    You can also search for this author in PubMed Google Scholar

  29. M. Della Santa
    View author publications

    You can also search for this author in PubMed Google Scholar

  30. P. Dessalvi
    View author publications

    You can also search for this author in PubMed Google Scholar

  31. F. Fiaccadori
    View author publications

    You can also search for this author in PubMed Google Scholar

  32. F. Figoli
    View author publications

    You can also search for this author in PubMed Google Scholar

  33. M. Florentino
    View author publications

    You can also search for this author in PubMed Google Scholar

  34. M. Franchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  35. P. L. Garavelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  36. F. Gherlinzoni
    View author publications

    You can also search for this author in PubMed Google Scholar

  37. F. Gianelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  38. M. G. Giudici
    View author publications

    You can also search for this author in PubMed Google Scholar

  39. C. Guglielmi
    View author publications

    You can also search for this author in PubMed Google Scholar

  40. G. Lambertenghi Deliliers
    View author publications

    You can also search for this author in PubMed Google Scholar

  41. F. Lanza
    View author publications

    You can also search for this author in PubMed Google Scholar

  42. F. Lombardi
    View author publications

    You can also search for this author in PubMed Google Scholar

  43. G. Luzi
    View author publications

    You can also search for this author in PubMed Google Scholar

  44. R. Luzzati
    View author publications

    You can also search for this author in PubMed Google Scholar

  45. A. Malfitano
    View author publications

    You can also search for this author in PubMed Google Scholar

  46. C. Malleo
    View author publications

    You can also search for this author in PubMed Google Scholar

  47. F. Mandelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  48. M. Marangolo
    View author publications

    You can also search for this author in PubMed Google Scholar

  49. A. Maringos
    View author publications

    You can also search for this author in PubMed Google Scholar

  50. G. Martignoni
    View author publications

    You can also search for this author in PubMed Google Scholar

  51. D. Milo
    View author publications

    You can also search for this author in PubMed Google Scholar

  52. V. Montesarchio
    View author publications

    You can also search for this author in PubMed Google Scholar

  53. L. Ortona
    View author publications

    You can also search for this author in PubMed Google Scholar

  54. G. Palmieri
    View author publications

    You can also search for this author in PubMed Google Scholar

  55. E. A. Parrinello
    View author publications

    You can also search for this author in PubMed Google Scholar

  56. N. Piersantelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  57. G. Pizzoccaro
    View author publications

    You can also search for this author in PubMed Google Scholar

  58. C. Pristerà
    View author publications

    You can also search for this author in PubMed Google Scholar

  59. F. Puppo
    View author publications

    You can also search for this author in PubMed Google Scholar

  60. A. Quaglino
    View author publications

    You can also search for this author in PubMed Google Scholar

  61. E. Raise
    View author publications

    You can also search for this author in PubMed Google Scholar

  62. A. Riccardi
    View author publications

    You can also search for this author in PubMed Google Scholar

  63. E. Ricchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  64. G. Rizzardini
    View author publications

    You can also search for this author in PubMed Google Scholar

  65. M. Rizzi
    View author publications

    You can also search for this author in PubMed Google Scholar

  66. F. Rizzo
    View author publications

    You can also search for this author in PubMed Google Scholar

  67. A. M. Rosci
    View author publications

    You can also search for this author in PubMed Google Scholar

  68. G. Rossi
    View author publications

    You can also search for this author in PubMed Google Scholar

  69. S. Sabbatani
    View author publications

    You can also search for this author in PubMed Google Scholar

  70. G. Saliva
    View author publications

    You can also search for this author in PubMed Google Scholar

  71. G. Salvi
    View author publications

    You can also search for this author in PubMed Google Scholar

  72. S. Saracchini
    View author publications

    You can also search for this author in PubMed Google Scholar

  73. G. Scalise
    View author publications

    You can also search for this author in PubMed Google Scholar

  74. A. Scanni
    View author publications

    You can also search for this author in PubMed Google Scholar

  75. A. Sinicco
    View author publications

    You can also search for this author in PubMed Google Scholar

  76. R. Sorio
    View author publications

    You can also search for this author in PubMed Google Scholar

  77. V. A. Squadrini
    View author publications

    You can also search for this author in PubMed Google Scholar

  78. R. Stellini
    View author publications

    You can also search for this author in PubMed Google Scholar

  79. V. Stracca Pansa
    View author publications

    You can also search for this author in PubMed Google Scholar

  80. E. Sulis
    View author publications

    You can also search for this author in PubMed Google Scholar

  81. A. Surbone
    View author publications

    You can also search for this author in PubMed Google Scholar

  82. A. Terragna
    View author publications

    You can also search for this author in PubMed Google Scholar

  83. A. Tognetti
    View author publications

    You can also search for this author in PubMed Google Scholar

  84. A. Vaglia
    View author publications

    You can also search for this author in PubMed Google Scholar

  85. R. Zagni
    View author publications

    You can also search for this author in PubMed Google Scholar

  86. V. Zagonel
    View author publications

    You can also search for this author in PubMed Google Scholar

  87. F. Gavosto
    View author publications

    You can also search for this author in PubMed Google Scholar

  88. S. Monfardini
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Division of Medical Oncology, Centro di Riferimento Oncologico, 33081, Aviano, Italy

    Silvio Monfardini

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Tirelli, U. et al. (1990). Non-Hodgkin’s Lymphomas in Patients with AIDS. In: Monfardini, S. (eds) The Management of Non-Hodgkin’s Lymphomas in Europe. ESO Intercity Report. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75528-6_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-75528-6_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-52297-3

  • Online ISBN: 978-3-642-75528-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation