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Macrophages/Reticulum Cells in Early and Late Phases of Lymphogenous Metastasis

  • Chapter
Reaction Patterns of the Lymph Node

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 84/2))

Abstract

In recent years, increasing interest has focused on the role of macrophages/reticulum cells in the local immune defense against malignant tumors. Within the peritumoral field, these cells are supposed to bear the main functional burden, together with lymphocytes (for reviews see Macher and Sorg 1986; Roitt et al. 1985). At present information is still scarce about their functional role in the lymph nodes during lymphogenous metastasis (Fossum and Ford 1985; Meyer 1982; Syrjänen 1982). Besides their well-known phagocytic properties, cytotoxic, cytostatic, and cytolytic capacities may be involved. In addition, there are interactions between macrophages/reticulum cells and both T and B lymphocytes during immune defense, and so macrophages/reticulum cells may be regarded as accessory cells in the induction of the tumor-associated immune response.

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Authors
  1. E. Vollmer
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  2. F. Shimamoto
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  3. V. Krieg
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  4. E. Grundmann
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Editors and Affiliations

  1. Gerhard-Domagk-Institut für Pathologie, Universität Münster, Domagkstraße 17, W-4400, Münster, Federal of Republic of Germany

    E. Grundmann Professor Dr.  & E. Vollmer Dr. Dr.  & 

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This chapter is dedicated to Prof. Dr. Walter Kocher, Berlin.

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© 1991 Springer-Verlag Berlin Heidelberg

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Vollmer, E., Shimamoto, F., Krieg, V., Grundmann, E. (1991). Macrophages/Reticulum Cells in Early and Late Phases of Lymphogenous Metastasis. In: Grundmann, E., Vollmer, E. (eds) Reaction Patterns of the Lymph Node. Current Topics in Pathology, vol 84/2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75522-4_3

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  • DOI: https://doi.org/10.1007/978-3-642-75522-4_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75524-8

  • Online ISBN: 978-3-642-75522-4

  • eBook Packages: Springer Book Archive

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