Lineage-Specific Receptors in the Diagnosis of Malignant Lymphomas and Myelomonocytic Neoplasms
Surface receptors usually represent transmembrane glycoproteins serving the ability of cells to react to environmental conditions. The reaction of ligands with the corresponding receptor is the decisive event promoting transmembrane signals and triggering a complicated chain of intracellular reactions. The overwhelming majority of surface receptors in hematopoietic cells regulate growth, differentiation, defense, adaptation, and other physiological cell functions. Their involvement in neoplastic processes is mostly secondary in nature, although they may be prone to allow external influences upon the dysregulated growth mechanisms.
KeywordsAcute Myeloid Leukemia Gene Rearrangement
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