Skip to main content
SpringerLink
Log in
Book cover

Cell Receptors pp 495–516Cite as

Lineage-Specific Receptors in the Diagnosis of Malignant Lymphomas and Myelomonocytic Neoplasms

  • Chapter

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 83))

Abstract

Surface receptors usually represent transmembrane glycoproteins serving the ability of cells to react to environmental conditions. The reaction of ligands with the corresponding receptor is the decisive event promoting transmembrane signals and triggering a complicated chain of intracellular reactions. The overwhelming majority of surface receptors in hematopoietic cells regulate growth, differentiation, defense, adaptation, and other physiological cell functions. Their involvement in neoplastic processes is mostly secondary in nature, although they may be prone to allow external influences upon the dysregulated growth mechanisms.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Alt F, Blackwell K, Yancopoulos GD (1987) Development of the primary antibody repertoire. Science 238:1079–1083

    Article  PubMed  CAS  Google Scholar 

  • Baumbach WR, Colston EM, Cole MD (1988) Integration of the BALB/c ecotropic provirus into the colony-stimulating factor-1 growth factor locus in a myc retro virus-induced murine monocyte tumor. J Virol 62:3151–3155

    PubMed  CAS  Google Scholar 

  • Bishop JM (1983) Cellular oncogenes and retroviruses. Ann Rev Biochem 52:301–354

    Article  PubMed  CAS  Google Scholar 

  • Bödewadt S, Radzun H J, Feller AC, Parwaresch MR (1986) Immunophenotyping of acute non-lymphoblastic leukaemias. Virchows Arch [B] 51:79–88

    Article  Google Scholar 

  • Brenner MB, Strominger JL, Krangel MS (1988) The γ/δ T-cell receptor. In: Dixon FJ (ed) Advances in immunology, vol 43. Academic, Orlando, pp 133–192

    Chapter  Google Scholar 

  • Campana D, Janossy G, Coustan-Smith E, Amlot PL, Tian WT, Wong L (1989) The expression of T-cell receptor-associated proteins during T-cell ontogeny in man. J Immunol 142:57–65

    PubMed  CAS  Google Scholar 

  • Cedar H (1988) DNA methylation and gene activity. Cell 53:3–4

    Article  PubMed  CAS  Google Scholar 

  • Champagne E, Sagman U, Biondi A, Lewis WH, Mak TW, Minden MD (1988) Structure and rearrangement of the T-cell receptor Jα locus in T-cells and leukemic T-cell lines. Eur J Immunol 18:1033–1038

    Article  PubMed  CAS  Google Scholar 

  • Cossman J, Uppenkamp M, Sundeen J, Coupland R, Raffeid M (1988) Molecular genetics and the diagnosis of lymphoma. Arch Pathol Lab Med 112:117–127

    PubMed  CAS  Google Scholar 

  • Coussens L, Van Beveren C, Smith D et al. (1986) Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus. Nature 320:277–280

    Article  PubMed  CAS  Google Scholar 

  • Davey MP, Bongiovanni KF, Kaulfersch W et al. (1986) Immunoglobulin and T-cell receptor gene rearrangement and expression in human lymphoid leukemia cells at different stages of maturation. Proc Natl Acad Sci USA 83:8759–8763

    Article  PubMed  CAS  Google Scholar 

  • Dexter TM, Allen TD (1983) The regulation of growth and development of normal and leukaemic cells. J Pathol 141:415–433

    Article  PubMed  CAS  Google Scholar 

  • Downward J, Yarden Y, Mayes E et al. (1984) Close similarity of epidermal growth factor receptor and v-erbB oncogene protein sequences. Nature 307:521–527

    Article  PubMed  CAS  Google Scholar 

  • Foon KA, Todd III RF (1986) Immunological classification of leukemia and lymphoma. Blood 68:1–31

    PubMed  CAS  Google Scholar 

  • Frank MM (1987) Complement in the pathophysiology of human disease. N Engl J Med 316:1525–1530

    Article  PubMed  CAS  Google Scholar 

  • Gisselbrecht S, Fichelson S, Sola B et al. (1987) Frequent c-fms activation by pro viral insertion in mouse myeloblastic leukaemias. Nature 329:259–261

    Article  PubMed  CAS  Google Scholar 

  • Goldstein JL, Ho YK, Basu SK, Brown MS (1979) Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc Natl Acad Sci (USA) 76:333–337

    Article  CAS  Google Scholar 

  • Griesser H, Mak TW (1988) Immunogenotyping in Hodgkin’s disease. Hematol Oncol 6:239–245

    Article  PubMed  CAS  Google Scholar 

  • Griesser H, Feller AC, Lennert K, Minden M, Mak TW (1986a) Rearrangement of the β chain of the T-cell antigen receptor and immunoglobulin genes in lymphoproliferative disorders. J Clin Invest 78:1179–1184

    Article  PubMed  CAS  Google Scholar 

  • Griesser H, Feller AC, Lennert K et al. (1986b) The structure of the T-cell gamma chain gene in lymphoproliferative disorders and lymphoma cell lines. Blood 68:592–594

    PubMed  CAS  Google Scholar 

  • Griesser H, Tkachuk D, Reis MD, Mak TW (1989) Gene rearrangements and translocations in lymphoproliferative diseases. Blood 73:1402–1415

    PubMed  CAS  Google Scholar 

  • Griesser H, Feller AC, Sterry W (1990) T cell receptor and immunoglobulin gene rearrangements in cutaneous T cell-rich pseudolymphomas. J Invest Dermatol 95 (in press)

    Google Scholar 

  • Hanson CA, Frizzera G, Patton DF, Peterson BA, McClain KL, Gajl-Peczalska KJ, Kersey JH (1988) Clonal rearrangement for immunoglobulin and T-cell receptor genes in systemic Castle-man’s disease. Am J Pathol 131:84–91

    PubMed  CAS  Google Scholar 

  • Hara J, Benedict SH, Mak TW, Gelfand EW (1987) T-cell receptor α-chain gene rearrangements in B-precursor leukemia are in contrast to the findings in T-cell acute lymphoblastic leukemia — comparative study of T-cell receptor gene rearrangement in childhood leukemia. J Clin Invest 80:1770–1777

    Article  PubMed  CAS  Google Scholar 

  • Hara J, Benedict SH, Champagne E, Takihara Y, Mak TW, Minden M, Gelfand EW (1988) T-cell receptor Ö gene rearrangements in acute lymphoblastic leukemia. J Clin Invest 82:1974–1981

    Article  PubMed  CAS  Google Scholar 

  • Haynes BF, Singer KH, Denning SM, Martin ME (1988) Analysis of expression of CD2, CD3, and T-cell antigen receptor molecules during early human fetal thymic development. J Immunol 141:3776–3784

    PubMed  CAS  Google Scholar 

  • Hogg N (1988) The structure and function of Fc receptors. Immunol Today 9:185–187

    Article  PubMed  CAS  Google Scholar 

  • Jenkinson EJ, Kingston R, Owen JJT (1987) Importance of IL-2 receptors in intra-thymic generation of cells expressing T-cell receptors. Nature 329:160–162

    Article  PubMed  CAS  Google Scholar 

  • Knapp W (1982) Monoclonal antibodies against differentiation antigens of myelopoiesis. Blut 45:301–308

    Article  PubMed  CAS  Google Scholar 

  • Kreipe H, Radzun HJ, Heidorn K, Parwaresch MR, Verrier B, Müller R (1986) Lineage-specific expression of c-fos and c-fms in human hematopoietic cells: discrepancies with the in vitro differentiation of leukemia cells. Differentiation 33:56–60

    Article  PubMed  CAS  Google Scholar 

  • Kreipe H, Radzun HJ, Rudolph P, Barth J, Hansmann ML, Heidorn K, Parwaresch MR (1988) Multinucleated giant cells generated in vitro: terminally differentiated macrophages with down-regulated c-fms expression. Am J Pathol 130:232–243

    PubMed  CAS  Google Scholar 

  • Kurland JS, Peius LM, Ralph P, Bockman RS, Moore MAS (1979) Induction of prostaglandin Esynthesis in normal and neoplastic macrophages: role for colony-stimulating factor(s) distinct from effects on myeloid progenitor cell proliferation. Proc Natl Acad Sci USA 76:2326–2341

    Article  PubMed  CAS  Google Scholar 

  • Ladner MB, Martin GA, Noble JA, Nikoloff DM, Tal R, Kawasaki ES, White TJ (1987) Human CSF-1: gene structure and alternative splicing of mRNA precursors. EMBO J 6:2693–2698

    PubMed  CAS  Google Scholar 

  • Leder LD (1967) Der Blutmonozyt. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Leder P (1982) The genetics of antibody diversity. Sci Am 246:72–83

    Article  Google Scholar 

  • Lefranc MP, Forster A, Baer T, Stinson MA, Rabbitts TH (1986) Diversity and rearrangement of the human T-cell rearranging γ genes: Nine germline variable genes belonging in two subgroups. Cell 45:237–246

    Article  PubMed  CAS  Google Scholar 

  • Lin HS, Gordon S (1979) Secretion of plasminogen activator by bone marrow-derived mononuclear phagocytes and its enhancement by colony-stimulating factor. J Exp Med 150:231–245

    Article  PubMed  CAS  Google Scholar 

  • Makgoba MW, Sanders ME, Luce GEG et al. (1988) ICAM-1, a ligand for LFA-1-dependent adhesion of B, T and myeloid cells. Nature 331:86–88

    Article  PubMed  CAS  Google Scholar 

  • McMichael A (1987) Leucocyte typing III - white cell differentiation antigens. Oxford University Press, Oxford

    Google Scholar 

  • Metcalf D (1986) The molecular biology and functions of the granulocyte-macrophage colony-stimulating factors. Blood 67:257–267

    PubMed  CAS  Google Scholar 

  • Metcalf D (1989) The molecular control of cell division, differentiation commitment and maturation in haematopoietic cells. Nature 339:27–30

    Article  PubMed  CAS  Google Scholar 

  • Nienhuis AW, Bunn HF, Turner PH, Gopal TV, Nash WG, O’Brien SJ, Sherr CJ (1985) Expression of the human c-fms proto-oncogene in hematopoietic cells and its deletion in the 5q-syndrome. Cell 42:421–428

    Article  PubMed  CAS  Google Scholar 

  • Parwaresch MR, Wacker HH (1984) Origin and kinetics of resident tissue macrophages. Parabiosis studies with radiolabeled leucocytes. Cell Tissue Kin 17:25–39

    CAS  Google Scholar 

  • Parwaresch MR, Radzun HJ, Feller AC, Peters KP, Hansmann ML (1983) Peroxidase-positive mononuclear leukocytes as possible precursors of human dendritic reticulum cells. J Immunol 131:2719–2725

    PubMed  CAS  Google Scholar 

  • Parwaresch MR, Kreipe H, Feigner J, Heidorn K, Jaquet K, Bödewadt-Radzun S, Radzun HJ (1990) M-CSF and M-CSF receptor gene expression in acute myelomonocytic leukemias. Leukemia Res 14:27–37

    Article  CAS  Google Scholar 

  • Radzun H J, Kreipe H, Heidorn K, Parwaresch MR (1988a) Modulation of c-fms proto-oncogene expression in human blood monocytes and macrophages. J Leukocyte Biol 44:198–204

    PubMed  CAS  Google Scholar 

  • Radzun HJ, Kreipe H, Zavzava ML, Parwaresch MR (1988b) Diversity of the human monocyte/ macrophage system as detected by monoclonal antibodies. J Leukocyte Biol 43:41–50

    PubMed  CAS  Google Scholar 

  • Radzun HJ, Parwaresch MR, Stingi G, Knapp W (1989) Neoplasms of monocytes, macrophages and dendritic cells. In: Asherson GL, Zembala M (eds) Human monocytes. Academic, London

    Google Scholar 

  • Rambaldi A, Wakamiya N, Vellenga E, Horiguchi J, Warren MK, Kufe D, Griffm JD (1988) Expression of the macrophage colony-stimulating factor and c-fms genes in human acute myeloblasts leukemia cells. J Clin Invest 81:1030–1035

    Article  PubMed  CAS  Google Scholar 

  • Reis MD, Griesser H, Mak TW (1988) Gene rearrangements in leukemias and lymphomas. In: Hoffbrand AV (ed) Recent advances in haematology, vol 5. Churchill Livingstone, Edinburgh, pp 99–120

    Google Scholar 

  • Rettenmier CW, Chen JH, Roussel MF, Sherr CJ (1985) The product of the c-fms proto-oncogene: a glycoprotein with associated tyrosine kinase activity. Sci Am 228:320–322

    CAS  Google Scholar 

  • Rosenthal AS (1980) Regulation of the immune response — role of the macrophage. N Engl J Med 303:1153–1156

    Article  PubMed  CAS  Google Scholar 

  • Roussel MF, Downing JR, Rettenmier CW, Sherr CJ (1988a) A point mutation in the extracellular domain of the human CSF-1 receptor (c-fms proto-oncogene product) activates its transforming potential. Cell 55:979–988

    Article  PubMed  CAS  Google Scholar 

  • Roussel MF, Rettenmier CW, Sherr CJ (1988b) Introduction of a human colony stimulating factor-1 gene into a mouse macrophage cell line induces CSF-1 independence but not tumorigenicity. Blood 71:1218–1225

    PubMed  CAS  Google Scholar 

  • Seremetis SV, Pelicci PG, Tabilio A et al. (1987) High frequency of clonal immunoglobulin and T-cell receptor gene rearrangements in acute myelogenous leukemia expressing terminal deoxynucleotidyl transferase. J Exp Med 165:1703–1712

    Article  PubMed  CAS  Google Scholar 

  • Sherr CJ, Rettenmier CW, Sacca R, Roussel MF, Look AT, Stanley ER (1985) The c-fms protooncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1. Cell 41:665–676

    Article  PubMed  CAS  Google Scholar 

  • Shimonkovitz RP, Husmann LA, Bevan M J, Crispe IN (1987) Transient expression of IL-2 receptor precedes the differentiation of immature thymocytes. Nature 329:157–159

    Article  Google Scholar 

  • Shreffler DC (1988) Seventy-five years of immunology: The view from the MHC. J Immunol 141:1791–1798

    PubMed  CAS  Google Scholar 

  • Simmons D, Makgoba MW, Seed B (1988) ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NC AM. Nature 331:624–627

    Article  PubMed  CAS  Google Scholar 

  • Sklar JL, Weiss LM, Cleary ML (1987) Diagnostic molecular biology of non-Hodgkin’s lymphomas. In: Berard CW, Dorman RF, Kaufman N (eds) Malignant lymphoma. Williams & Wilkins, Baltimore, pp 204–224

    Google Scholar 

  • Southern EM (1975) Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 98:503–517

    Article  PubMed  CAS  Google Scholar 

  • Suchi T, Lennert K, Tu LY, Kikuchi M, Sato E, Stansfeld AG, Feller AC (1987) Histopathology and immunohistochemistry of peripheral T-cell lymphomas: a proposal for their classification. J Clin Pathol 40:995–1015

    Article  PubMed  CAS  Google Scholar 

  • Takihara Y, Champagne E, Griesser H et al. (1988) Sequence and organization of the human δ chain gene. Eur J Immunol 18:283–287

    Article  PubMed  CAS  Google Scholar 

  • Tkachuk D, Griesser H, Feller AC, Lennert K, Mak TW (1988) Rearrangement of the T-cell locus in lymphoproliferative disorders. Blood 72:353–357

    PubMed  CAS  Google Scholar 

  • Tonegawa S (1985) The molecules of the immune system. Sci Am 253:122–131

    Article  PubMed  CAS  Google Scholar 

  • Toyonaga B, Mak TW (1987) Genes of the T-cell antigen receptor in normal and malignant T-cells. Ann Rev Immunol 5:585–620

    Article  CAS  Google Scholar 

  • Unanue ER (1976) Secretory function of mononuclear phagocytes. A review. Am J Pathol 83:396–417

    PubMed  CAS  Google Scholar 

  • Unanue ER (1980) Cooperation between mononuclear phagocytes and lymphocytes in immunity. N Engl J Med 303:977–985

    Article  PubMed  CAS  Google Scholar 

  • Waldmann TA (1987) The arrangement for immunoglobulin and T-cell receptor genes in human lymphoproliferative disorders. In: Dixon FJ (ed) Advances in immunology, vol 40. Academic, Orlando, pp 247–321

    Chapter  Google Scholar 

  • Wang C, Kelleher CA, Cheng GYM et al. (1988) Expression of the CSF-1 gene in the blast cells of acute myeloblastic leukemia: association with reduced growth capacity. J Cell Physiol 135:133–138

    Article  PubMed  CAS  Google Scholar 

  • Warren MK, Ralph P (1986) Macrophage growth factor CSF-1 stimulates human monocyte production of interferon, tumor necrosis factor, and colony stimulating activity. J Immunol 137:2281–2285

    PubMed  CAS  Google Scholar 

  • Weiss LM, Hu E, Wood GS, Moulds C, Cleary ML, Warnke R, Sklar J (1985) Clonal rearrangements of T-cell receptor genes in mycosis fungoides and dermatopathic lymphadenopathy. N Engl J Med 313:539–544

    Article  PubMed  CAS  Google Scholar 

  • Weiss LM, Wood GS, Ellisen LW, Reynolds TC, Sklar J (1987) Clonal T-cell populations in pityriasis lichenoides et varioliformis acuta (Mucha-Habermann disease). Am J Pathol 126:417–421

    PubMed  CAS  Google Scholar 

  • Weiss LM, Picker LJ, Grogan TM, Warnke RA, Sklar JA (1988) Absence of clonal beta and gamma T-cell receptor gene rearrangements in a subset of peripheral T-cell lymphomas. Am J Pathol 130:436–442

    PubMed  CAS  Google Scholar 

  • Winoto A, Baltimore D (1989) Separate lineages of T-cells expressing the β and γ/δ receptors. Nature 338:430–432

    Article  PubMed  CAS  Google Scholar 

  • Woolford J, McAuliffe A, Rohrschneider LR (1988) Activation of the feline c-fms proto-oncogene: multiple alterations are required to generate a fully transformed phenotype. Cell 55:965–977

    Article  PubMed  CAS  Google Scholar 

  • Xu DQ, Guilhot S, Galibert F (1985) Restriction fragment length polymorphism of the human c-fms gene. Proc Natl Acad Sci USA 82:2862–2865

    Article  PubMed  CAS  Google Scholar 

  • Yanagi Y, Yoshikai Y, Leggett K, Clark SP, Alecander J, Mak TW (1984) A human T-cell specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains. Nature 308:145–149

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. M. R. Parwaresch
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Kreipe
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. J. Radzun
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. Griesser
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institut für Pathologie, Universität Hamburg, Martinistraße 52, W-2000, Hamburg 20, Federal Republic of Germany

    G. Seifert Professor Dr.

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Parwaresch, M.R., Kreipe, H., Radzun, H.J., Griesser, H. (1991). Lineage-Specific Receptors in the Diagnosis of Malignant Lymphomas and Myelomonocytic Neoplasms. In: Seifert, G. (eds) Cell Receptors. Current Topics in Pathology, vol 83. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75515-6_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-75515-6_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75517-0

  • Online ISBN: 978-3-642-75515-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation