rIL-2 Immunotherapy for 19 Children with Advanced Metastatic Neuroblastoma
Considerable progress has been achieved in the treatment of stage IV neuroblastoma in children over 1 year of age. Induction therapy and surgery followed by vincristine, high-dose melphalan, total body irridiation, and autologous bone marrow transplantation (ABMT) enable the achievement of 40% progression-free survival at 2 years post-transplantation . However, late relapses occurring up to 72 months post-graft, with a projected disease- free survival at 5 years of only 20% to 25%, are a major concern. Therefore, new therapeutic approaches are needed; spontaneous regression of this tumor in children below 1 year of age favors a role of the immune system in antitumoral defense and the potential benefit of immunotherapy. However, since neuroblastoma cells lack class I and II major histocompatibility complex (MHC) antigens, any attempt to stimulate antitumoral defense should involve non-MHC-restricted immunity.
This work was supported by grant n°6245 from the Association pour la Recherche sur le Cancer, réseau INSERM LMCE n°48–60-22, and Comite de la Savoie of the Ligue Nationale contre le Cancer (grant RS-01()88).
KeywordsNatural Killer Natural Killer Cell Autologous Bone Marrow Transplantation Lymphokine Activate Killer Lymphokine Activate Killer Cell
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