Surface Expression of Interleukin-2 Receptors and CD4 Molecules by Human Eosinophils is Induced by GM-CSF and IL-3
The CD4 molecule, a 55–60 kDa glycoprotein, is expressed on the surface of a helper/inducer subset of human T cells that mediates the interaction of T cells with cells bearing MHC class II proteins during an immune response . In addition to its expression on subsets of T cells, CD4 can also be detected on the surface of cells of the monocyte/macrophage lineage. Similarly, the p55 chain of the IL-2 receptor can be induced on both T cells and monocytes  and acts as a low affinity binding site for IL-2. Eosinophils are notable participants in immunological responses during allergic reactions and helminthic infections . However, a cooperative mechanism for eosinophil stimulation by lymhocytes has so far not been defined. Recently, it has been shown that mature human eosinophils have the capacity to express MHC class II protein  providing the first clues for a possible T cell/eosinophil interaction.
KeywordsHuman Eosinophil Adherent Monolayer Percoll Density Gradient Centrifugation
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