The Role of Interferon-α2 (IFN-α2) in the Treatment of Low-Grade Non-Hodgkin’s Lymphoma. Preliminary Results of a Randomized Study:IFN-α2 Plus Chlorambucil Versus Chlorambucil Alone

  • T. Chisesi
  • L. Rancan
  • G. Capnist
  • G. Santini
  • A. Porcellini
  • R. Sertoli
  • A. Contu
  • V. Rizzoli
  • R. Coser
  • F. Benedetti
Conference paper

Abstract

Interferon-α has been shown as an active agent in the treatment of hematological malignancies especially in hairy cell leukemia (HCL) [1] and low-grade non-Hodgkin’s lymphoma (NHL) [2].

Keywords

Toxicity Lymphoma Leukemia Anemia Interferon 

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References

  1. 1.
    Horning SJ, Merigan TC, Krown SE (1985) Human interferon alpha in malignant lymphoma and Hodgkin’s disease. Cancer 56:1305PubMedCrossRefGoogle Scholar
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    Quesada JR, Hersh EM, Manning JT, et al. (1986) Treatment of hairy cell leukemia with recombinant alpha interferon blood 68:493–497Google Scholar
  3. 3.
    Chisesi T, Capnist G, Vespignani M, Cetto G (1987) Interferon alpha 2b and chlorambucil in the treatment of non-Hodgkin’s lymphoma. Invest New Drugs 1:35–40Google Scholar
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    Roth MS, Foon A (1986) Alpha interferon in the treatment of hematologic malignancies. Am J Med 81:871–882PubMedCrossRefGoogle Scholar
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    Gams R, Gordon D, Guaspari A, Turtle R (1984) Phase II trial of human polyclonal lymphoblastoid interferon (Wellcome) in the management of malignant lymphoma. J Clin Oncol 3:65Google Scholar
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    Steis GR, Foon KA, Longo DL (1987) Current and future use of recombinant interferon alpha in the treatment of low grade non-Hodgkin’s lymphoma. Cancer 59/3 Suppl 658–663PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag, Berlin Heidelberg 1990

Authors and Affiliations

  • T. Chisesi
  • L. Rancan
  • G. Capnist
  • G. Santini
  • A. Porcellini
  • R. Sertoli
  • A. Contu
  • V. Rizzoli
  • R. Coser
  • F. Benedetti

There are no affiliations available

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