Recombinant Human Granulocyte-Macrophage Colony-stimulating Factor for the Mobilization of Hemopoietic Progenitors Prior to Autologous Peripheral Blood Stem Cell Transplantation

  • R. Haas
  • U. Bredthauer
  • M. Körbling
  • W. Hunstein
Conference paper

Abstract

Autologous bone marrow transplantation (ABMT) is based on the administration of myeloablative chemotherapy and/or total body irradiation (TBI) followed by the infusion of autologous bone marrow-derived hemopoietic stem cells [1]. An alternative to the reinfusion of bone marrow is the transplantation of peripheral blood-derived stem cells (ABSCT) [2, 3]. ABSCT provides a new therapeutical approach, especially for those patients with previous radiotherapy involving the sites of bone marrow harvesting. An efficient method of increasing the number of circulating stem cells prior to the collection is the administration of cytoreductive chemotherapy to induce a rebound of circulating hemopoietic progenitors [2, 4]. With the availability of the recombinant human hemopoietic growth factors, a new and more physiological method for the mobilization of hemopoietic stem cells from the bone marrow is feasible [5].

Keywords

Catheter Lymphoma DMSO Sarcoma Myeloma 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Armitage JO, Gale RP (1986) Bone marrow autotransplantation in man:Report of an international cooperative study. Lancet (2):960Google Scholar
  2. 2.
    Körbling M, Dörken B, Ho AD, Pezzutto A, Hunstein W, Fliedner TM (1986) Autologous transplantation of blood derived hematopoietic stem cells after myeloablative therapy in a patient with Burkitt’s lymphoma. Blood 67:529PubMedGoogle Scholar
  3. 3.
    Kessinger A, Armitage JO, Landmark JD, Weisenburger DD (1986) Reconstitution of human hemopoietic function with autologous cryopreserved circulating stem cells. Exp Hematol 14:192PubMedGoogle Scholar
  4. 4.
    Richman CM, Weiner R, Yankee, RA (1976) Increase in circulating stem cells following chemotherapy in man (1976). Blood 47:1031PubMedGoogle Scholar
  5. 5.
    Socinski MA, Elias A, Schnipper L, Caunistra SA, Antman KH, Griffin ID (1988) Granulocyte-macrophage colony-stimulating factor expands the circulating haemopoietic progenitor cell compartment in man. Lancet 1:1194PubMedCrossRefGoogle Scholar
  6. 6.
    Metcalf D, Begley CG, Johnson GR, Nicola NA, Vadas NA, Lopez AF, Williamson DJ, Wong GG, Clark SC, Wang EA (1986) Biologic properties in vitro of a recombinant human granulocte-macrophage colony-stimlating factor. Blood 67:37PubMedGoogle Scholar
  7. 7.
    Fauser AA, Messner HA (1979) Identification of megakaryocytes, macrophages, and eosinophils in colonies of human bone marrow. Blood 53:1023PubMedGoogle Scholar
  8. 8.
    McCredie KB, Hersh EM, Freireich EJ (1971) Cells capable of colony formation in the peripheral blood of man. Science 171:293PubMedCrossRefGoogle Scholar
  9. 9.
    McCarthy DM, Goldman JM (1984) Transfusion of circulating stem cells. Crit Rev Clin Lab Sci 20:1PubMedCrossRefGoogle Scholar
  10. 10.
    Körbling M, Fehrentz D, Baumann M, Pezzutto A, Haas R, Mende U, Konig A, Knauf W, Rother K, Hunstein W (1988) Hochdosierte Konsolidierungstherapie mit autologer Blut-stammzell-Transplantation. In:Lutz D, Heinz R, Nowotny H, Stacher A (eds):Leukämien und Lymphome, München, Wien, Baltimore, Urban und Schwarzenberg, pp 37.Google Scholar

Copyright information

© Springer-Verlag, Berlin Heidelberg 1990

Authors and Affiliations

  • R. Haas
  • U. Bredthauer
  • M. Körbling
  • W. Hunstein

There are no affiliations available

Personalised recommendations