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Human NK Clones Regulate B-cell Development by Release of IFN-γ and TNF-α

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Book cover Cytokines in Hemopoiesis, Oncology, and AIDS

Abstract

Natural killer (NK) cells are primarily defined as effectors in non-MHC restricted cytolysis of tumor targets [1, 2]. More recently, however, increasing evidence has appeared that NK cells play an important role in the regulation of hematopoiesis and the immune response [3]. It has been demonstrated that NK cells have the capacity to secrete a range of lymphokines which induce B-cell growth and differentiation [4].

This work was supported by a grant of the Deutsche Forchungsgemeinschaft, Schm 596/2-2.

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References

  1. Ritz J, Schmidt RE, Michon J, Hercend T, Schlossman SF (1988) Characterization of functional surface structures on human NK cells. Adv Immunol 42:181

    Article  PubMed  CAS  Google Scholar 

  2. Hercend T, Schmidt RE, (1988) Functions and uses of natural killer cells. Immunol Today 9:231

    Article  Google Scholar 

  3. Herrman F, Schmidt RE, Ritz J, Griffin JD (1987) In vitro regulation of human hematopoiesis by NK cells:analysis at a clonal level. Blood 69:246

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  4. Anegon I, Cuturi MC, Trinchieri G, Perussia B (1988) Interaction of Fc receptor (CD16) ligands induces transcription of IL2 receptor (CD25) and lymphokine genes and expression of their products in human NK cells. J Exp Med 167:452

    Article  PubMed  CAS  Google Scholar 

  5. Werfel T, Uciechowski P, Teteroo PAT, Kurrle R, Deicher H, Schmidt RE (1989) Activation of cloned natural killer cells via FcRIII. J Immunol 142:1102

    PubMed  CAS  Google Scholar 

  6. Schubert J, Lanier L, Schmidt RE (1989) CD report:CD56 In:Knapp W, Dörken B, Rieber P, Schmidt RE, Stein H, van dem Borne AEGKr (eds) Leukocyte typing IV. Oxford University Press, Oxford (in press)

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  7. Tedder TF, Schmidt RE, Rudd MM, Kornachi J, Ritz J, Schlossman SF (1986) Function of the LFA-1 and T4 molecules in the direct activation of resting human B lymphocytes by T lymphocytes. Eur J Immunol 16:1539

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© 1990 Springer-Verlag, Berlin Heidelberg

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Kolanus, W., Becker, J., Schmidt, R.E. (1990). Human NK Clones Regulate B-cell Development by Release of IFN-γ and TNF-α. In: Freund, M., Link, H., Welte, K. (eds) Cytokines in Hemopoiesis, Oncology, and AIDS. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75510-1_33

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  • DOI: https://doi.org/10.1007/978-3-642-75510-1_33

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-52281-2

  • Online ISBN: 978-3-642-75510-1

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