Cytokine Interactions in Normal and Malignant Hematopoiesis

  • N. A. Cicco
  • W. Oster
  • A. Lindemann
  • R. Mertelsmann
  • F. Herrmann
Conference paper

Abstract

Blood cell production is known to be regulated by a complex, integrated network of cell-derived cytokines that either interact directly with their hematopoietic target cells or induce accessory marrow elements to express other polypeptide factors. As a group, these colony stimulating factors (CSFs) are able to elicit multiple functional effects on responding cells, ranging from proliferative stimulation to differentiation commitment, maturation induction, and functional activation of mature cells (see [8] for review). Although the physiologic roles of these hormone-like polypeptides and their relative contributions to normal hematopoiesis remain to be elucidated, they seem to play a major role in adapting levels of blood cells to various states of increased demand. Recently, in vitro studies were performed to assess the involvement of this group of hormone-like glycoproteins in the process of malignant transformation of hematopoietic cells, particularly regarding disease states such as acute leukemias. Although many questions about the biology of acute myelogenous leukemia (AML) and acute lymphocytic leukemia (ALL) remain to be answered, during the past few years much information has been accumulated suggesting a role for various cytokines in the pathophysiology of these and other lympho/hematopoietic disorders.

Keywords

Lymphoma Leukemia Oncol Polypeptide Interferon 

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References

  1. 1.
    Bloomfield CD, de la Chapelle A (1987) Chromosome abnormalities in acute nonlymphocytic leukemia:clinical and biological significance. Semin Oncol 14:372–383PubMedGoogle Scholar
  2. 2.
    Brennan JK, Di Persio JF, Abboud CN, Lichtman MA (1979) The exceptional responsiveness of certain human myeloid leukemia cells to colony-stimulating activity. Blood 54:1230–1239PubMedGoogle Scholar
  3. 3.
    Broudy VC, Kaushansky K, Segal GM, Harlan JM, Adamson JW (1986) Tumor necrosis factor type alpha stimulates human endothelial cells to produce granulocyte macrophage colony stimulating factor. Proc Natl Acad Sci USA 83:7467–7471PubMedCrossRefGoogle Scholar
  4. 4.
    Broxmeyer HE . Negative regulators of hematopoiesis (1984) In:Wright D, Greenberger J (eds) Long term bone marrow culture. Liss, New York, pp 363–397Google Scholar
  5. 5.
    Broxmeyer HE (1986) Biomolecule-cell interactions and the regulation of myelopoiesis. Int J Cell Cloning 4:378–404PubMedGoogle Scholar
  6. 6.
    Cantrell MA, Anderson D, Ceretti DP, Price V, McKereghan K, Tushinski RJ, Mochizuki DY, Larsen A, Grabstein K, Gillis S, Cosman D (1985) Cloning, sequence, and expression of human granulocyte-macrophage colony-stimulating factor. Proc Natl Acad Sci USA 82:6250–6254PubMedCrossRefGoogle Scholar
  7. 7.
    Cheng GYM, Kelleher CA, Miyauchi J, Wang C, Wong G, Clark SC, McCulloch EA, Minden MD (1988) Structure and expression of genes of GM-CSF and G-CSF in blast cells from patients with acute myeloblasts leukemia. Blood 71:204–208PubMedGoogle Scholar
  8. 8.
    Clark SC, Kamen R (1987) The human hematopoietic colony-stimulating factors. Science 236:1229–1237PubMedCrossRefGoogle Scholar
  9. 9.
    Delwel R, Dorssers L, Touw I, Wagemaker G, Lowenberg B (1987) Human recombinant multilineage colony-stimulating factor (interleukin-3):stimulator of acute myelocytic leukemia progenitor cells in vitro. Blood 70:333–336PubMedGoogle Scholar
  10. 10.
    Griffin JD, Young DC, Herrmann F, Wiper D, Wagner K, Sabbath K (1986) Effects of recombinant human GM-CSF on proliferation of clonogenic cells in acute myeloblasts leukemia. Blood 76:1448–1453Google Scholar
  11. 11.
    Griffin JD, Rambaldi A, Vellenga E, Young DC, Ostapovicz D, Cannistra S (1987) Secretion of interleukin-1 by acute myeloblasts leukemia cells in vitro induces endothelial cells to secrete colony stimulating factors. Blood 70:1218–1221PubMedGoogle Scholar
  12. 12.
    Herrmann F, Oster W, Meurer SC, Lindemann A, Mertelsmann R (1988) Interleukin 1 induces T cell production of granulocyte-macrophage colony-stimulating factor. J Clin Invest 81:1415–1418PubMedCrossRefGoogle Scholar
  13. 13.
    Herrmann F, Oster W, Lindemann A, Ganser A, Dorken B, Knapp W, Griffin JD, Mertelsmann R (1987) Leukemic colony-forming cells in acute myeloblasts leukemia:maturation hierarchy and growth conditions. Hamatol Bluttransfus 31:185–190Google Scholar
  14. 14.
    Horiguchi J, Warren MK, Kufe D (1987) Expression of the macrophage-specific colony- stimulating factor in human monocytes treated with granulocyte-macrophage colony- stimulating factor. Blood 69:1259–1261PubMedGoogle Scholar
  15. 15.
    Huebner K, Isobe M, Croce CM, Golde DW, Kaufman SE, Gasson JC (1985) The human gene encoding GM-CSF is at 5q29-q32, the chromosome region deleted in the 5q-anomaly. Science 230:1282–1285PubMedCrossRefGoogle Scholar
  16. 16.
    Jaye M, Howk R, Burgess W, Ricca GA, Chiu IM, Ravera MW, O’Brien SJ, Modi WS, Maciag T, Drohan WN (1986) Human endothelial cell growth factor:cloning, nucleotide sequence, and chromosome localization. Science 231:541–545CrossRefGoogle Scholar
  17. 17.
    Kawasaki ES, Ladner MB, Wang AM, Van Arsdell J, Warren MK, Coyne MY, Schweickart VL, Lee MT, Wilson KJ, Stanley ER, Ralph P, Mark DF (1985) Molecular cloning of a complementary DNA encoding human macrophage-specific colony-stimulating factor (CSF-1). Science 230:291–296PubMedCrossRefGoogle Scholar
  18. 18.
    Kelleher C, Miyauchi J, Wong G, Clark S, Minden MD, McCulloch EA (1987) Synergism between recombinant growth factors, GM-CSF and G-CSF, activity on the blast cells of acute myeloblasts leukemia. Blood 69:1498–1503PubMedGoogle Scholar
  19. 19.
    Kobilka BK, Dixon RA, Frielle T, Dohlmann HG, Bolansowski MA, Sigal IS, Yang-Feng TL, Francke U, Caron MG, Lefkowitz RJ (1987) C-DNA fo the human beta-2-adrenergic receptor:protein with multiple membrane-spanning domains encoded by a gene whose chromosmal location is shared with that of the receptor for platelet derived growth factor. Proc Natl Acad Sci USA 84:46–50PubMedCrossRefGoogle Scholar
  20. 20.
    Ladner BM, Martin GA, Noble JA, Nokoloff DM, Tal R, Kawasaki ES, White TJ (1987) Human CSF-1:gene structure and alternative splicing of mRNA precursors. EMBO J 6:2693–2698PubMedGoogle Scholar
  21. 21.
    Le Beau MM, Epstein ND, O’Brien SJ, Nienhuis A, Yang YC, Clark SC, Rowley JD (1987) The interleukin 3 gene is located on human chromosome 5 and is deleted in myeloid leukemias with a deletion of 5q. Proc Natl Acad Sci USA 84:5913–5917PubMedCrossRefGoogle Scholar
  22. 22.
    Lin FH, Suggs S, Lin CH, Browne JK, Smalling R, Egrie JC, Chen KK, Fox GM, Martin F, Stabinsky Z, Badrawi SM, Lai PH, Goldwasser E (1985) Cloning and expression of the human erythropoietin gene. Proc Natl Acad Sci USA 82:7580–7584PubMedCrossRefGoogle Scholar
  23. 23.
    Lindemann A, Oster W, Ziegler-Heitbrock HWL, Mertelsmann R, Herrmann F (1989) Recombinant granulocyte-macrophage colony stimulating factor induces cyrokine secretion by polymorphonuclear leukocytes. J Clin Invest 83:1308–1312PubMedCrossRefGoogle Scholar
  24. 24.
    Meuer SC, Meyer zum Buschenfelde KH (1984) T cell receptor triggering induces responsiveness to IL-1 and IL-2 but does not lead to T cell proliferation. J Immunol 136:4106–4122Google Scholar
  25. 25.
    Munker R, Gasson J, Ogawa M, Koeffler HP (1986) Recombinant human TNF induces production of granulocyte-monocyte colony-stimulating factor. Nature 328:79–82CrossRefGoogle Scholar
  26. 26.
    Oster W, Lindemann A, Mertelsmann R, Herrmann F (1988) Regulation of gene expression of M-, G-, GM-, and multi-CSF in normal and malignant hematipoietic cells. Blood Cells 14:443–462PubMedGoogle Scholar
  27. 27.
    Oster W, Lindemann A, Mertelsmann R, Herrmann F (1989) Cellular sources of CSF in the peripheral blood. Eur J Immunol 19:543–547PubMedCrossRefGoogle Scholar
  28. 28.
    Oster W, Lindemann A, Mertelsmann R, Herrmann F (1989) GM-CSF and multi-CSF regulate monocyte secretion of G-CSF. Blood 73:64–67PubMedGoogle Scholar
  29. 29.
    Oster W, Lindemann A, Horn S, Mertelsmann R, Herrmann F (1987) Tumor necrosis factor ( TNF)-alpha but not TNF-beta induces secretion of colony stimulating factor for macrophages by human monocytes. Blood 70:1700–1703PubMedGoogle Scholar
  30. 30.
    Oster W, Cicco NA, Klein H, Fleischer B, Hirano T, Kishimoto T, Lindemann A, Mertelsmann R, Herrmann F (1989) Participation of the monokines IL-6, TNF-alpha, and IL-l-beta secreted by acute myelogenous leukemia blasts in autocrine and paracrine leukemia growth control. J Clin Invest 84:451–457CrossRefGoogle Scholar
  31. 31.
    Otsuka T, Miyajima A, Brown N, Otsu K, Abrams J, Sealand S, Caux C, Malefijt RDW, De Vries J, Meyerson P, Yokota K, Gemmel L, Rennick D, Lee F, Arai N, Arain KI, Yokota T (1988) Isolation and characterization of an expressible cDNA encoding human IL-3. J Immunol 140:2288–2295PubMedGoogle Scholar
  32. 32.
    Pettenati KJ, Le Beau MM, Lemons RS, Shima EA, Kawasaki ES, Larson RA, Sherr CJ, Diaz MO, Rowel JD (1987) Assignment of CSF-1 to 5q33.1:evidence for clustering of genes regulating hematopoiesis and for their involvement in the deletion of the long arm of chromosome 5 in myeloid disorders. Proc Natl Acad Sci USA 83:2970–2974CrossRefGoogle Scholar
  33. 33.
    Ralph P, Warren MK, Lee MT, Csejtey J, Weaver JF, Broxmeyer HE, Williams DE, Stanley EA, Kawasaki ED (1986) Inducible production of human macrophage growth factor, CSF-1. Blood 68:633–639PubMedGoogle Scholar
  34. 34.
    Rambaldi A, Wahamiya N, Vellenga E, Horiguchi J, Warren K, Kufe D, Giffin JD (1988) Expression of the macrophage colony-stimulating factor and c-fms genes in human acute myeloblasts leukemia cells. J Clin Invest 81:1030–1035PubMedCrossRefGoogle Scholar
  35. 35.
    Sandberg AA (1986) The chromosomes in human leukemia. Semin Hematol 23:201–217PubMedGoogle Scholar
  36. 36.
    Sherr CJ, Rettenmier CW, Sacca R, Roussel MF, Look AT, Stanley ER (1985) The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1. Cell 41:665–676PubMedCrossRefGoogle Scholar
  37. 37.
    Sieff CA, Schickwann T, Faller V (1987) Interleukin 1 induces cultured human endothelial cell production of granulocyte-macrophage colony-stimulating factor. J Clin Invest 79:48–51PubMedCrossRefGoogle Scholar
  38. 38.
    Simmers RN, Webber LM, Shannon MF, Garson OM, Wong G, Vadas MA, Sutherland GR (1987) Localisation of the G-CSF gene on chromosome 17 proximal to the breakpoint in t(15;17) in acute promyelocitic leukemia. Blood 70:330–332PubMedGoogle Scholar
  39. 39.
    Souza LM, Boone TC, Gabrilove JL, Lai PH, Zsabo KM, Murdock DC, Chazin VR, Bruszewski J, Lu H, Chen KK, Barendt J, Platzer E, Moore MAS, Mertelsmann R, Welte K (1986) Recombinant human granulocyte colony-stimulating factor:effects on normal and leukemic myeloid cells. Science 232:61–65PubMedCrossRefGoogle Scholar
  40. 40.
    Stanley E, Metcalf D, Sobieszcuk P, Gough NM, Dunn AR (1985) The structure and expression of the murine gene encoding granulocyte-macrophage colony-stimulating factor:evidence for utilisation of alternative promoters. EMBO J 4:2569–2573PubMedGoogle Scholar
  41. 41.
    Urdal DL, Park LS (1988) Studies on hematopoietic growth factors receptors using human recombinant IL-3, GM-CSF, G-CSF, M-CSF, IL-1 and IL-4. Behring Inst Mitt 83:27–39PubMedGoogle Scholar
  42. 42.
    Vellenga E, Rambaldi A, Ernst T, Ostapovicz D, Griffin JD (1988) The G-CSF and GM- CSF genes are independently regulated in human monocytes. Blood 70:1529–1532Google Scholar
  43. 43.
    Vellenga E, Young DC, Wagner K, Wiper D, Ostapovicz D, Griffin JD (1987) The effects of GM-CSF and G-CSF in promoting growth of clonogenic cells in acute myeloblasts leukemia. Blood 69:1771–1776PubMedGoogle Scholar
  44. 44.
    Wisnjewski LP, Hirschhorn K (1983) Acquired partial deletions of the long arm of chromosome 5 in hematological disorders. Am J Hemat 15:295–301CrossRefGoogle Scholar
  45. 45.
    Yang YC, Ciarletta AB, Temple PA, Chung MP, Kovacic S, Witeck-Giannptti JS, Leary AC, Kriz R, Donahue RE, Wong GG, Clark SC (1986) Human IL-3 (multi-CSF):identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3. Cell 47:3–10PubMedCrossRefGoogle Scholar
  46. 46.
    Yarden Y, Escobedo JA, Kuang WJ, Yang-Feng TL, Harkins RN, Franke U, Fried VA, Ullrich A, Williams LT (1986) Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors. Nature 323:226–232PubMedCrossRefGoogle Scholar
  47. 47.
    Ymer S, Tucker QJ, Sanderson CJ, Hapel AJ, Cambell HD, Young IG (1985) Constitutive synthesis of interleukin-3 by leukemia cell line WEHI-3B is due to retroviral insertion near the gene. Nature 317:255 - 258PubMedCrossRefGoogle Scholar
  48. 48.
    Young DC, Griffin JD (1986) Autocrine secretion of GM-CSF in acute myeloblasts leukemia. Blood 68:1178–1181PubMedGoogle Scholar
  49. 49.
    Young DC, Demetri GD, Ernst TJ, Cannistra SA, Griffin JD (1988) In vitro expression of colony-stimulating factor genes by human acute myeloblasts leukemia. Exp Hematol 16:378–382PubMedGoogle Scholar
  50. 50.
    Zucali JR, Dinarello CA, Obion DJ, Gross MA, Anderson J, Weiner RS (1986) Interleukin 1 stimulates fibroblasts to produce granulocyte-macrophage colony stimulating activity and prostaglandin E2. J Clin Invest 77:1837–1842CrossRefGoogle Scholar

Copyright information

© Springer-Verlag, Berlin Heidelberg 1990

Authors and Affiliations

  • N. A. Cicco
  • W. Oster
  • A. Lindemann
  • R. Mertelsmann
  • F. Herrmann

There are no affiliations available

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