Cytokine Interactions in Normal and Malignant Hematopoiesis
Blood cell production is known to be regulated by a complex, integrated network of cell-derived cytokines that either interact directly with their hematopoietic target cells or induce accessory marrow elements to express other polypeptide factors. As a group, these colony stimulating factors (CSFs) are able to elicit multiple functional effects on responding cells, ranging from proliferative stimulation to differentiation commitment, maturation induction, and functional activation of mature cells (see  for review). Although the physiologic roles of these hormone-like polypeptides and their relative contributions to normal hematopoiesis remain to be elucidated, they seem to play a major role in adapting levels of blood cells to various states of increased demand. Recently, in vitro studies were performed to assess the involvement of this group of hormone-like glycoproteins in the process of malignant transformation of hematopoietic cells, particularly regarding disease states such as acute leukemias. Although many questions about the biology of acute myelogenous leukemia (AML) and acute lymphocytic leukemia (ALL) remain to be answered, during the past few years much information has been accumulated suggesting a role for various cytokines in the pathophysiology of these and other lympho/hematopoietic disorders.
KeywordsMultiple Myeloma Acute Myelogenous Leukemia Acute Myeloblastic Leukemia Hematopoietic Growth Factor Acute Lymphatic Leukemia
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