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Combined Cytogenetic and Proliferation Studies of GM-CSF-Stimulated Bone Marrow Cells in Myelodysplasia and Acute Leukemia

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Cytokines in Hemopoiesis, Oncology, and AIDS
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Abstract

The intention of our study was to investigate the influence of granulocyte marophage colony stimulating factor (GM-CSF) on in vitro proliferation and clonal composition of bone marrow cultures from patients with leukemia on the one hand and from those with myelodysplasia and aplastic anemia on the other.

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References

  1. Fonatsch C, Schaadt M, Kirchner H, Diehl V (1980) A possible correlation between the degree of karyotype aberrtions and the rate of sister chromatid exchanges in lymphoma lines. Int J Cancer 26:749–756

    Article  PubMed  CAS  Google Scholar 

  2. Cohen MM, Kunska A, Astemborski JA, McCulloch D, Paskewitz D (1986) Effect of low- level, 60-Hz electromagnetic fields on human lymphoid cells:I. Mitotic rate and chromosome breakage in human peripheral lymphocytes. Bioelectromagnetics 7:415–423

    Article  PubMed  CAS  Google Scholar 

  3. Gold EJ, Conjalka M, Pelus LM, Jhanvar SC, Broxmeyer H, Middleton AB, Clarkson BD, Moore MAS (1983) Marrow cytogenetic and cell-culture analyses of the myelodysplastic syndromes:insights into pathophysiology and prognosis. J. Clin Oncol 10:627–634

    Google Scholar 

  4. Nicola NA (1987) Why do hemopoietic growth factor receptors interact with each other? Immunology Today 8:134–140

    Article  Google Scholar 

  5. Ganser A, Volkers B, Greher J, Ottmann O, Walther F, Bergmann L, Holzer D (1989) Recombinant human granulocyte-macrophage colony-stimulating factor in patients with myelodysplastic syndrome:phase I/II trials. Blood 73:31–37

    PubMed  CAS  Google Scholar 

  6. Dedhar S, Gaboury L, Galloway P, Eaves C (1988) Human granulocyte-marcophage colony- stimulating factor is a growth factor active on a variety of cell types of nonhemopoietic origin. Proc Natl Acad Sci USA 85:9253–9257

    Article  PubMed  CAS  Google Scholar 

  7. Griffin JD, Young D, Herrmann D, Wiper D, Wagner K, Sabbath KD (1986) Effects of recombinant human GM-CSF on proliferation of clonogenic cells in acute myeloblasts leukemia. Blood 67:1448–1453

    PubMed  CAS  Google Scholar 

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© 1990 Springer-Verlag, Berlin Heidelberg

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Haase, D., Fonatsch, C. (1990). Combined Cytogenetic and Proliferation Studies of GM-CSF-Stimulated Bone Marrow Cells in Myelodysplasia and Acute Leukemia. In: Freund, M., Link, H., Welte, K. (eds) Cytokines in Hemopoiesis, Oncology, and AIDS. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75510-1_17

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  • DOI: https://doi.org/10.1007/978-3-642-75510-1_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-52281-2

  • Online ISBN: 978-3-642-75510-1

  • eBook Packages: Springer Book Archive

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