New Concepts in Fluid Therapy for Patients with Intraabdominal Infection
Patients with severe intraabdominal infection develop volume requirements far beyond what would compensate for the estimated losses. These result from a massive shift of fluid and solutes from the intravascular to the interstitial compartment due to local and generalized permeability defects  and from fluid and solute losses via drainages or open packed laparostomy wounds. In addition to fluid losses from the circulation, the circulating blood volume usually is further decreased by the distributive defect associated with peripheral pooling of blood. The immediate consequences of delays in appropriate fluid therapy are inadequate organ perfusion and function.
KeywordsFluid Therapy Acute Necrotizing Pancreatitis Colloid Osmotic Pressure Intraabdominal Infection Pulmonary Artery Wedge Pressure
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