The Effect of Blanks and Antigen Sharing in the HLA System on the Paternity Index
The HLA system is the single most polymorphic, well defined, genetic system in use today as a component of the testing profile in cases of disputed parentage. Over 40,000 phenotypes can be detected utilizing HLA-A and HLA-B locus markers. In spite of this, antigen sharing between the alleged father (AF) and mother (M) is relatively common. Missing antigens, blanks, are also commonly observed, especially in blacks, but also in whites as well. This study was undertaken to determine the effect of HLA-A and/or B antigen sharing between the AF and M, and blanks at these loci, on the HLA Paternity Index (PI) in white non-exclusion cases where the AF was assumed to be the true father.
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