Mode of Action Studies

  • Annemarie Polak
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 96)


There are two approaches to the discovery of new antifungal drugs: the rational and the empirical. Up to now, none of the antifungal drugs available has been found on the basis of a truly rational approach. This may largely be explained by the unfortunate fact that fungi, like their human hosts, are eucaryotic organisms and hence the number of potential targets for specific drug action is limited. Furthermore, basic research on the biochemistry and physiology of the fungal cell was until recently rather neglected in contrast to the profound biochemical knowledge accumulated for bacterial cells. For a successful rational approach to designing antifungals it is important that detailed knowledge of the enzymatic steps used by fungal cells be available. Besides basic research on the biochemistry of fungi, mode of action studies with existing antimycotics may contribute to a deeper insight into the meta-bolism of fungal cells. Such mode of action studies are urgently needed and should not only be performed in industrial laboratories but also in an academic environment.


Fungal Cell Antimicrob Agent Sterol Biosynthesis Ergosterol Biosynthesis Triazole Derivative 
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© Springer-Verlag Berlin Heidelberg 1990

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  • Annemarie Polak

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