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Systemic Azole Antifungal Drugs — Into the 1990s

  • John R. Graybill
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 96)

Abstract

Amphotericin B marked the beginning of the real antifungal era. Beginning with the 1960s, there was a broad spectrum antifungal drug that could be administered parenterally and could arrest the course of devastating systemic fungal infections. Amphotericin B revolutionized the treatment of the major endemic mycoses (histoplasmosis, coccidioidomycosis, blastomycosis, and paracoccidioidomycosis) and also provided the first effective therapy for cryptococcal meningitis. Were efficacy the only relevant question today, it would still be difficult to find treatment significantly superior to amphotericin B. However, the toxicity of amphotericin B and the need for intravenous administration have made prolonged therapeutic regimens difficult to administer. In addition, the relative rarity of systemic fungal infections was an insufficient stimulus for pharmaceutical companies to undertake the increasingly costly investment required to identify and develop new classes of drugs for systemic mycoses.

Keywords

Antimicrob Agent Neutropenic Patient Cryptococcal Meningitis Systemic Mycosis Antifungal Azole 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • John R. Graybill

There are no affiliations available

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