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Chemotherapy of Fungal Diseases pp 421–437Cite as

Fungal Infections and AIDS

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 96))

Abstract

Fungi feature prominently among the opportunistic organisms which can cause disease during the development of infection with HIV virus. The fungi encountered are the same as those found in other situations characterized by depressed cell-mediated immunity. Some mycoses are superficial - cutaneous or mucocutaneous - and generally benign, e.g. candidosis, dermatophytosis, pityrosporosis; others are deep-seated and potentially serious, e.g. cryptococcosis, histoplasmosis, coccidioidomycosis (Armstrong 1988; Holmberg and Meyer 1986; Schaffner 1984; Spencer and Jackson 1989). Aspergillosis and disseminated candidosis are rarely found in this situation, but a number of more obscure fungal infections are now being reported in the literature.

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References

  • Abrams DI, Robia M, Blumenfeld W, Simonson J, Cohen MB, Hadeley WK (1984) Disseminated coccidioidomycosis in AIDS, N Engl J Med 310: 986–987

    Article  PubMed  CAS  Google Scholar 

  • Ancelle T, Dupouy-Camet J, Pujol F, Nassif X, Ferradini L, Lapierre J (1988) Un cas de pénicilliose disséminée à Pénicillium marneffei chez un malade atteint de SIDA. Bull Soc Fr Mycol Méd 17: 73–76

    Google Scholar 

  • Armstrong D (1988) Life-threatening fungal infections in patients with the acquired immunodeficiency syndrome. Ann N Y Acad Sci 544: 443–450

    Article  PubMed  CAS  Google Scholar 

  • Badillet G, Traoré F (1987) Dermatophytes et sérologie HIV positive. Bull Soc Fr Mycol Med 16: 95–98

    Google Scholar 

  • Barr CE, Torosian JP (1986) Oral manifestations in inpatients with AIDS or AIDS-related complex. Lancet ii: 288

    Google Scholar 

  • Bibler MR, Luber HJ, Glueck HI, Ester SA (1986) Disseminated sporotrichosis in a patient with HIV infection after treatment for acquired factor VII inhibitor. JAMA 156: 3125–3126

    Article  Google Scholar 

  • Bottone EJ, Salkin IF, Hurd NJ, Wormser GP (1987) Serogroup distribution of Cryptococcus neoformans in patients with AIDS. J Inf Dis 156: 242

    Article  CAS  Google Scholar 

  • Bourée P, Thulliez P, Le Bras P, Ellrodt A, Palazzo L, Quillard J, Caquet R, Drouhet E (1984) Cryptococcose diffuse chez un Zairois atteint de SIDA. Bull Soc Fr Mycol Méd 13: 195–200

    Google Scholar 

  • Brandicourt O, Datry A, Rosenbaum W, Rosenheim M, Duflo B, Denis M, Brucker G, Gentilini M (1986) Cryptococcose et SIDA: à propos de 11 observations. Bull Soc Fr Mycol Méd 15: 349–352

    Google Scholar 

  • Brivet F, Roulot D, Naveau S, Delfraissy JF, Goujard C, Tertian G, Cartier I, Drouhet E, Dupont B (1986) The acquired immunodeficiency syndrome: B-cell lymphoma, histoplasmosis, and ethics and economics. Ann Int Med 104:447

    Google Scholar 

  • Bronnimann DA, Adam RA, Galgiani JN, Habib MP, Petersen EA, Porter B, Bloom JW (1987) Coccidioidomycosis in the acquired immunodeficiency syndrome. Ann Int Med 106:372–379

    PubMed  CAS  Google Scholar 

  • Byrne WR, Wajszczuk CP (1988) Cryptococcal meningitis in AIDS: successful treatment with fluconazole after failure of amphotericin B. Ann Int Med 108:384–385

    PubMed  CAS  Google Scholar 

  • Chuck SL, Sande MA (1989) Infections with Cryptococcus neoformans in the acquired immunodeficiency syndrome. N Engl J Med 321: 794–799

    Article  PubMed  CAS  Google Scholar 

  • Clissold SP (1987) Safety in clinical practice. In: Jones HE (ed) Ketoconazole today. A review of clinical experience. ADIS Press, Manchester, pp 79–91

    Google Scholar 

  • Clotet B, Grifol M, Parra O, Boix J, Junca J, Tor J, Foz M (1986) Asymptomatic esophageal candidiasis in the acquired immunodeficiency-syndrome-related complex. Ann Int Med 105: 145

    PubMed  CAS  Google Scholar 

  • De Gans J, Eeftinck Schattenkerk JKM, Van Ketel RJ (1988) Itraconazole as maintenance treatment for cryptococcal meningitis in the acquired immunodeficiency syndrome. Br Med J 296:339

    Article  Google Scholar 

  • Deluol AM, Marche C, Bizet C, Katlama C (1987) Histoplasmose disséminée au cours du SIDA. Bull Soc Fr Mycol Méd 16:363–366

    Google Scholar 

  • Denning DW, Tucker RM, Hanson LH, Hamilton JR, Stevens DA (1989) Itraconazole therapy for cryptococcal meningitis and cryptococcosis. Arch Int Med 149:2301–2308

    Article  CAS  Google Scholar 

  • De Wit S, Weerts D, Goossens H, Clumeck N (1989) Comparison of fluconazole and ketoconazole for oropharyngeal candidiasis in AIDS. Lancet i: 746–748

    Google Scholar 

  • Dismukes WE (1988) Cryptococcal meningitis in patients with AIDS. J Inf Dis 157: 624–628

    Article  CAS  Google Scholar 

  • Drouhet E, Dompmartin D, Papachristou-Morati A, Ravisse P (1980) Dermatite expérimentale à Pityrosporum ovale et/ou Pityrosporum orbiculare chez le cobaye et la souris. Sabouraudia 18:149–156

    Article  PubMed  CAS  Google Scholar 

  • Dupont B, Drouhet E (1987) Cryptococcal meningitis and fluconazole. Ann Int Med 106:778

    PubMed  CAS  Google Scholar 

  • Dupont B, Drouhet E (1988) Fluconazole in the management of oropharyngeal candidosis in a predominantly HIV antibody-positive group of patients. J Med Vet Mycol 26:67–71

    Article  PubMed  CAS  Google Scholar 

  • Dupont B, Sansonetti P, Fleury J, Ravisse P, Drouhet E (1984) Histoplasmose septicémique au cours d’un SIDA, présence inhabituelle de H. capsulatum dans les polynucléaires. Med Mal Inf 14: 261

    Google Scholar 

  • Dupouy-Camet J, Vilette B, Thulliez M, Noizat F, Moyal M, Vedel G, Lapierre J (1987) Histoplasmose disséminée chez un malade grand voyageur atteint de SIDA. Bull Soc Fr Mycol Méd 16: 81–83

    Google Scholar 

  • Eng RHK, Bishburg E, Smith SM, Kapita R (1986) Cryptococcal infections in patients with acquired immune deficiency syndrome. Am J Med 81: 19–23

    Article  PubMed  CAS  Google Scholar 

  • Farting CF, Staughton RCD, Rowland Payne CME (1985) Skin disease in homosexual patients with acquired immune deficiency syndrome (AIDS) and lesser forms of human T cell leukemia virus ( HTLV III) disease. Clin Exp Dermatol 10:3–12

    Article  Google Scholar 

  • Gall AA, Koss MN, Hawkins J, Evans S, Einstein H (1986) The pathology of pulmonary cryptococcal infections in the acquired immunodeficiency syndrome. Arch Pathol Lab Med 110: 501–507

    Google Scholar 

  • Goodman DS, Teplitz ED, Wishner A, Klein RS, Burk PG, Hershenbaum E (1987) Prevalence of cutaneous disease in patients with acquired immunodeficiency syndrome ( AIDS) or AIDS-related complex. J Am Acad Derm 17:210–220

    Article  PubMed  CAS  Google Scholar 

  • Grant SM, Clissold SP (1989) Itraconazole: a review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in superficial and systemic mycoses. Drugs 37:310–344

    Article  PubMed  CAS  Google Scholar 

  • Graybill JR (1987) Fluconazole efficacy in animal models of mycotic diseases. In: Fromtling RA (ed) Recent trends in the discovery, development and evaluation of antifungal agents. JR Prous, Barcelona, pp 113–124

    Google Scholar 

  • Graybill JR (1988) Histoplasmosis and AIDS. J Inf Dis 158: 623–626

    Article  CAS  Google Scholar 

  • Holmberg K, Meyer RD (1986) Fungal infections in patients with AIDS and AIDS related complex. Scand J Inf Dis 18:179–192

    Article  CAS  Google Scholar 

  • Huang CT, McGarry T, Cooper S, Saunders R, Andavoen R (1987) Disseminated histoplasmosis in the acquired immunodeficiency syndrome. Report of five cases from a non-endemic area. Arch Int Med 147: 1181–1184

    Article  CAS  Google Scholar 

  • Joy M (1984) Oral candidiasis and AIDS. N Engl J Med 311: 1378–1379

    PubMed  CAS  Google Scholar 

  • Kapend’a K, Komichelo K, Swinne D, Vandepitte J (1987) Meningitis due to Cryptococcus neoformans biovar gattii in a Zairean AIDS patient. Eur J Clin Microbiol 6: 320–321

    Article  PubMed  Google Scholar 

  • Klein RS, Harris CA, Small CB, Moll B, Lesser M, Friendland GH (1984) Oral candidiasis in high-risk patients as the initial manifestation of the acquired immunodeficiency syndrome. N Engl J Med 311: 354–358

    Article  PubMed  CAS  Google Scholar 

  • Kovacs A, Forthal DN, Kovacs JA, Overturf GD (1984) Disseminated coccidioidomycosis in a patient with acquired immune deficiency syndrome. West J Med 140: 447–449

    PubMed  CAS  Google Scholar 

  • Kovacs JA, Kovacs AA, Polis M, Wright WC, Gill VJ, Tuazon CV, Gelmann EP, Lane HC, Longfield R, Overturf G, Macher AM, Fauci AS, Parrillo JE, Bennett JE, Masur H (1985) Cryptococcosis in the acquired immunodeficiency syndrome. Ann Int Med 103:533–538

    PubMed  CAS  Google Scholar 

  • Lake-Bakaar G, Tom W, Lake-Bakaar D, Gupta N, Beidas S, Elsakr M, Straus E, (1988) Gastropathy and ketoconazole malabsorption in the acquired immunodeficiency syndrome ( AIDS ). Ann Int Med 109:471–475

    CAS  Google Scholar 

  • Levy RM, Bredesen DE, Rosenblum ML (1985) Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): experience at UCSF and review of the literature. J Neurosurg 62: 475–495

    Article  PubMed  CAS  Google Scholar 

  • Levy-Klotz B, Badillet G, Cavelier-Balloy B, Chemaly P, Leverger G, Civatte J (1985) Alternariose cutanée au cours d’un SIDA. Ann Dermatol Venereol 112: 739–740

    PubMed  CAS  Google Scholar 

  • McKinsey DS, Gupta MR, Riddler SA, Driks MR, Smith DL, Kurtin PJ (1989) Long- term amphotericin B therapy for disseminated histoplasmosis in patients with the acquired immunodeficiency syndrome ( AIDS ). Ann Int Med 111:655–659

    PubMed  CAS  Google Scholar 

  • Matthews R, Burnie J, Smith D, Clark I, Midgley J, Conolly M, Gazzard B (1988) Candida and AIDS: evidence for protective antibody. Lancet ii: 263–266

    Google Scholar 

  • Morin O, Barrier J, Haloun A, Buzelin F, Baron D (1987) Détresse respiratoire aiguë due à une cryptococcose foudroyante mortelle chez un malade atteint du SIDA. Bull Soc Fr Mycol Méd 16: 325–328

    Google Scholar 

  • Mostaza JM, Barbado FJ, Fernandez-Martin J, Pena-Yanez J, Vasquez-Rodriguèz JJ (1989) Cutaneoarticular mucormycosis due to Cunninghamella bertholletiae in a patient with AIDS. Rev Inf Dis 11: 316–318

    Article  CAS  Google Scholar 

  • Pedersen C, Gerstoft J, Lindhardt BO, Sindrup J (1987) Candida esophagitis associated with acute human immunodeficiency virus infection. J Inf Dis 156: 529–530

    Article  CAS  Google Scholar 

  • Peeters P, Depré G, Rickaert F, Coremans-Pelseneer J, Serruys E (1987) Disseminated African histoplasmosis in a white heterosexual male patient with the acquired immune deficiency syndrome. Mykosen 30:449–453

    PubMed  CAS  Google Scholar 

  • Perfect JR, Savani DV, Durack DT (1986) Comparison of itraconazole and fluconazole in treatment of cryptococcal meningitis and Candida pyelonephritis in rabbits. Antimicrob Agents Chemother 29:579–583

    PubMed  CAS  Google Scholar 

  • Peto TEA, Bull R, Millard PR, Mackenzie DWR, Campbell CK, Haines ME, Mitchell RG (1988) Systemic mycosis due to Pénicillium marneffei in a patient with antibody to human immunodeficiency virus. J Infection 16:285–290

    Article  CAS  Google Scholar 

  • Rhoads JL, Wright DC, Redfield RR, Burke DS (1987) Chronic vaginal candidiasis in women with human immunodeficiency virus infection. JAMA 257:3105–3107

    Article  PubMed  CAS  Google Scholar 

  • Roberts CJ (1984) Coccidioidomycosis in acquired immune deficiency syndrome: depressed humoral as well as cellular immunity. Am J Med 76: 734–736

    Article  PubMed  CAS  Google Scholar 

  • Roux P, Basset D, Delacourt T, Mayaud C, Touboul JL, Fouret P, Feuilhade M, Revuz J, Poirot JL, Marteau M, Lancastre F (1985) Problèmes posés par la cryptococcose au course du SIDA. Bull Soc Fr Mycol Méd 14:255–260

    Google Scholar 

  • Roux P, Feuilhade M, Touboul JL, Basset D, Delacour T, Revuz T, Fouret P, Mayaud C, Lancastre F (1986) Intérêt de la recherche systématique d’antigène sérique cryptococcique au cours du SIDA: à propos d’un cas de cryptococcose disséminée asymptomatique. Bull Soc Fr Mycol Méd 15:361–364

    Google Scholar 

  • Roux P, Touboul JL, Basset D, Delacour T, Mayaud C, England D, Lancastre F (1987) Localisation pulmonaire de la cryptococcose au cours du SIDA: à propos de 6 cas. Bull Soc Fr Mycol Méd 16:113–116

    Google Scholar 

  • Saag MS, Dismukes WE (1988) Azole antifungal agents: emphasis on new triazoles. Antimicrob Agents Chemother 32:1–8

    PubMed  CAS  Google Scholar 

  • Salberg DJ, Venkatachalam H (1986) Disseminated coccidioidomycosis presenting in AIDS. VA Practitioner 3: 89–93

    Google Scholar 

  • Schaffner A (1984) Acquired immune deficiency syndrome: is disseminated aspergillosis predictive of underlying cellular immune deficiency? J Inf Dis 149:828–829

    Article  CAS  Google Scholar 

  • Shimizu RY, Howard DH, Clancey MN (1986) The variety of Cryptococcus neoformans in patients with AIDS. J Inf Dis 154: 1042

    Article  CAS  Google Scholar 

  • Spencer PM, Jackson G (1989) Fungal and mycobacterial infections in patients infected with the human immunodeficiency virus. J Antimicrob Chemother 23 (Suppl A):107–125

    Article  PubMed  Google Scholar 

  • Stern JJ, Hartman BJ, Sharkey P, Rowland V, Squires KE, Murray HW, Graybill JR (1988) Oral fluconazole therapy for patients with acquired immunodeficiency syndrome and cryptococcosis: experience with 22 patients. Am J Med 85: 477–480

    Article  PubMed  CAS  Google Scholar 

  • Sugar AM, Saunders C (1988) Oral fluconazole: a suppressive therapy of disseminated cryptococcosis in patients with acquired immunodeficiency syndrome. Am J Med 85:481–489

    Article  PubMed  CAS  Google Scholar 

  • Tavitian A, Raufman JP, Rosenthal LE (1986) Oral candidiasis as a marker for esophageal candidiasis in the acquired immunodeficiency syndrome. Ann Int Med 104:54–55

    PubMed  CAS  Google Scholar 

  • Taylor MN, Baddour L, Alexander JR (1984) Disseminated histoplasmosis associated with the acquired immune deficiency syndrome. Am J Med 77:579–580

    Article  PubMed  CAS  Google Scholar 

  • Torssander J, Morfeld-Manson L, Biberfeld G, Karlson A, Putkonen PO, Wasserman J (1987) Oral Candida albicans in HIV infection. Scand J Inf Dis 19: 291–295

    Article  CAS  Google Scholar 

  • Tucker RM, Denning DW, Dupont B, Stevens DA (1990) Itraconazole therapy of chronic coccidioidal meningitis. Ann Int Med 112:108–112

    PubMed  CAS  Google Scholar 

  • Van Cutsem J, Van Gerven F, Janssen PAJ (1987) The in vitro and in vivo antifungal activity of itraconazole. In: Fromtling RA (ed) Recent trends in the discovery, development and evaluation of antifungal agents. JR Prous, Barcelona, pp 177–192

    Google Scholar 

  • Vant Wout JW, De Graeff-Meeder ER, Paul LC, Kuis W, Van Furth R (1988) Treatment of two cases of cryptococcal meningitis with fluconazole. Scand J Inf Dis 20: 193–198

    Article  Google Scholar 

  • Viviani MA, Tortorano AM (1986) Surveillance de la cryptococcose chez les sujets ä risque ou atteints de SIDA. Bull Soc Fr Mycol Méd 15:105–108

    Google Scholar 

  • Viviani MA, Tortorano AM, Giani PC, Arid C, Goglio A, Crocchiolo P, Almaviva M (1987) Itraconazole for cryptococcal infection in the acquired immunodeficiency syndrome. Ann Int Med 106: 166

    PubMed  CAS  Google Scholar 

  • Wheat LJ, Slama TG, Norton JA, Kohler RB, Eitzen HE, French MLV, Sathapatayavongs B (1982) Risk factors for disseminated or fatal histoplasmosis. Ann Int Med 96:159–163

    PubMed  CAS  Google Scholar 

  • Wheat LJ, Slama TG, Zeckel M (1985) Histoplasmosis in the acquired immune deficiency syndrome. Am J Med 78: 203–210

    Article  PubMed  CAS  Google Scholar 

  • Wheat LJ, Kohler RB, Tewar RP (1988) Diagnosis of disseminated histoplasmosis by detection of Histoplasma capsulatum antigen in serum and urine specimens. N Engl J Med 314: 83–88

    Article  Google Scholar 

  • Wheeler RR, Peacock JE, Cruz JM, Richter JE (1987) Esophagitis in the immunocompromised host: role of esophagoscopy in diagnosis

    Article  CAS  Google Scholar 

  • Wiest PM, Wiese K, Jacobs MR, Morrissey AB, Abelson TI, Wilt W, Lederman MM (1987) Alternaria infection in a patient with acquired immunodeficiency syndrome: case report and review of invasive Alternaria infections. Rev Inf Dis 9: 799–803

    Google Scholar 

  • Zuger A, Lonie E, Molzman RS, Simberkoff MS, Rahal J J (1988) Cryptococcal disease in patients with the acquired immunodeficiency syndrome. Ann Int Med 104: 234–240

    Google Scholar 

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  1. Bertrand Dupont
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Editors and Affiliations

  1. ICI Pharmaceuticals, Mereside, Alderley Park, SK104TG, Macclesfield, Cheshire, England

    John F. Ryley

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Dupont, B. (1990). Fungal Infections and AIDS. In: Ryley, J.F. (eds) Chemotherapy of Fungal Diseases. Handbook of Experimental Pharmacology, vol 96. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75458-6_20

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  • DOI: https://doi.org/10.1007/978-3-642-75458-6_20

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