Products of Separate Genes Encoded Within Minor Histocompatibility Loci Stimulate Class I and Class II MHC-Restricted T Cells
Minor histocompatibility (H) loci encode polymorphic gene products that act as tissue transplantation barriers. More than 40 of these loci have been identified through the production of minor H congenic strains of mice; however, because of the inherent complexity of the cellular processes leading to tissue rejection, the nature of the polymorphic genes comprising minor H loci has remained elusive. We have been using in vitro approaches employing minor H antigen-specific T cell clones as genetic probes for analyzing minor H loci. The purpose of this report is to summarize our recent results and to discuss how the results provide a novel view of the genetic structure of minor H loci.
KeywordsMajor Histocompatibility Complex Congenic Strain Landmark Locus Major Histocompatibility Complex Protein Backcross Mouse
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- Davis AP, and Roopenian, DC. Complexity at the mouse minor histocompatibility locus H-4. Immunogenetics, in pressGoogle Scholar
- Roopenian DC, and Anderson PS. (1988) Generation of helper cell-independent cytotoxic T cells is dependent upon L3T4-positive helper T cells. J.Immunol. 141: 392–7.Google Scholar
- Roopenian DC, and Davis AP. (1989) Responses against antigens encoded by the H-3 histocompatibility locus: antigens stimulating class I MHC and class II MHC restricted T cells are encoded by separate genes. Immunogenetics, in pressGoogle Scholar