Abstract
Minor histocompatibility (H) loci encode polymorphic gene products that act as tissue transplantation barriers. More than 40 of these loci have been identified through the production of minor H congenic strains of mice; however, because of the inherent complexity of the cellular processes leading to tissue rejection, the nature of the polymorphic genes comprising minor H loci has remained elusive. We have been using in vitro approaches employing minor H antigen-specific T cell clones as genetic probes for analyzing minor H loci. The purpose of this report is to summarize our recent results and to discuss how the results provide a novel view of the genetic structure of minor H loci.
Supported by N. I. H. grants # AI 24544 and 2 S07 RR05545 and A.C.S. grant # IN115. Its contents do not necessarily represent the views of the N.I.H.
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© 1990 Springer-Verlag Berlin Heidelberg
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Roopenian, D.C., Davis, A.P. (1990). Products of Separate Genes Encoded Within Minor Histocompatibility Loci Stimulate Class I and Class II MHC-Restricted T Cells. In: Egorov, I.K., David, C.S. (eds) Transgenic Mice and Mutants in MHC Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75442-5_9
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DOI: https://doi.org/10.1007/978-3-642-75442-5_9
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