Products of Separate Genes Encoded Within Minor Histocompatibility Loci Stimulate Class I and Class II MHC-Restricted T Cells

  • D. C. Roopenian
  • A. P. Davis
Conference paper


Minor histocompatibility (H) loci encode polymorphic gene products that act as tissue transplantation barriers. More than 40 of these loci have been identified through the production of minor H congenic strains of mice; however, because of the inherent complexity of the cellular processes leading to tissue rejection, the nature of the polymorphic genes comprising minor H loci has remained elusive. We have been using in vitro approaches employing minor H antigen-specific T cell clones as genetic probes for analyzing minor H loci. The purpose of this report is to summarize our recent results and to discuss how the results provide a novel view of the genetic structure of minor H loci.


Major Histocompatibility Complex Congenic Strain Landmark Locus Major Histocompatibility Complex Protein Backcross Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Davis AP, and Roopenian, DC. Complexity at the mouse minor histocompatibility locus H-4. Immunogenetics, in pressGoogle Scholar
  2. Germain RJ. (1986) The ins and outs of antigen processing. Nature 332: 687–9CrossRefGoogle Scholar
  3. Morrison LA, Lukacher AE, Braciale VL, Fan D, and Braciale TJ. (1986) Differences in antigen presentation to MHC class I- and class Il-restricted influenza virus-specific cytolytic T lymphocyte clones. J. Exp. Med. 163: 903–21PubMedCrossRefGoogle Scholar
  4. Roopenian DC, and Anderson PS. (1988) Generation of helper cell-independent cytotoxic T cells is dependent upon L3T4-positive helper T cells. J.Immunol. 141: 392–7.Google Scholar
  5. Roopenian DC, and Davis AP. (1989) Responses against antigens encoded by the H-3 histocompatibility locus: antigens stimulating class I MHC and class II MHC restricted T cells are encoded by separate genes. Immunogenetics, in pressGoogle Scholar
  6. von Boehmer H, Haas W. (1979) Distinct Ir genes for helper and cytotoxic T cells in the cytotoxic T cell response to H-Y. J Exp Med 150: 1134–42CrossRefGoogle Scholar
  7. Hurme M., C. M. Hetherington, P. R. Chandler, and E. Simpson. (1978) Cytotoxic T-cell responses to H-Y: Mapping of Ir genes. J. Exp Med 147: 758–67PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • D. C. Roopenian
  • A. P. Davis
    • 1
  1. 1.The Jackson LaboratoryBar HarborUSA

Personalised recommendations