Products of Separate Genes Encoded Within Minor Histocompatibility Loci Stimulate Class I and Class II MHC-Restricted T Cells

  • D. C. Roopenian
  • A. P. Davis
Conference paper

Abstract

Minor histocompatibility (H) loci encode polymorphic gene products that act as tissue transplantation barriers. More than 40 of these loci have been identified through the production of minor H congenic strains of mice; however, because of the inherent complexity of the cellular processes leading to tissue rejection, the nature of the polymorphic genes comprising minor H loci has remained elusive. We have been using in vitro approaches employing minor H antigen-specific T cell clones as genetic probes for analyzing minor H loci. The purpose of this report is to summarize our recent results and to discuss how the results provide a novel view of the genetic structure of minor H loci.

Keywords

Recombination Influenza Haas 

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • D. C. Roopenian
  • A. P. Davis
    • 1
  1. 1.The Jackson LaboratoryBar HarborUSA

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