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Influence of MHC and Non-MHC Genes on Tumorigenesis and the Use of the Recombinant Congenic Strains as a Novel Tool for the Genetic Analysis of Tumor Susceptibility

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Transgenic Mice and Mutants in MHC Research

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Abstract

One of the main developments in the contemporary biology is the rapid progress in the structural analysis of the mammalian genome, concentrated mainly on two species - the human and the mouse. A specific potential of the analysis of the mouse genome resides in the possibility of combining the structural analysis with the study of the genetic determination of various functional traits. This contribution of mouse studies is especially valuable in view of the limited possibilities of direct biological experiments in humans.

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Author information

Authors and Affiliations

  1. Department of Molecular Genetics, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Huis), Plesmanlaan 121, 1066 XC, Amsterdam, The Netherlands

    P. Demant, L. C. J. M. Oomen, C. J. A. Moen & M. A. Van Der Valk

  2. Department of Clinical Oncology, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Huis), Plesmanlaan 121, 1066 XC, Amsterdam, The Netherlands

    A. A. M. Hart

  3. Department of Laboratory Animal Science, University of Utrecht, Utrecht, The Netherlands

    L. F. M. Van Zutphen

Authors
  1. P. Demant
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  2. L. C. J. M. Oomen
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  3. C. J. A. Moen
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  4. M. A. Van Der Valk
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  5. A. A. M. Hart
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  6. L. F. M. Van Zutphen
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Editor information

Editors and Affiliations

  1. The Jackson Laboratory, Bar Harbor, ME, 04609, USA

    Igor K. Egorov Ph.D., D.Sci.

  2. Department of Immunology, Mayo Medical School, Mayo Clinic, Rochester, MN, 55905, USA

    Chella S. David Ph.D.

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© 1990 Springer-Verlag Berlin Heidelberg

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Demant, P., Oomen, L.C.J.M., Moen, C.J.A., Van Der Valk, M.A., Hart, A.A.M., Van Zutphen, L.F.M. (1990). Influence of MHC and Non-MHC Genes on Tumorigenesis and the Use of the Recombinant Congenic Strains as a Novel Tool for the Genetic Analysis of Tumor Susceptibility. In: Egorov, I.K., David, C.S. (eds) Transgenic Mice and Mutants in MHC Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75442-5_40

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  • DOI: https://doi.org/10.1007/978-3-642-75442-5_40

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75444-9

  • Online ISBN: 978-3-642-75442-5

  • eBook Packages: Springer Book Archive

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