Abstract
Mutations in the major histocompatibility complex (MHC) have been used to delineate the structure and function of these polymorphic molecules (Klein 1986). The original descriptions of these cell surface glycoproteins were concerned with their function as transplantation antigens (allorecognition). However, a more recently recognized function of the class I MHC protein is in the presentation of viral antigens to MHC compatible cytotoxic T lymphocytes (H-2 restriction). We have applied a method of generating random mutations in the class I MHC molecule H-2Dp to further determine regions of the molecule important for these immunologic functions.
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© 1990 Springer-Verlag Berlin Heidelberg
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Muller, D., Hobbs, M.M., Murray, R., Pederson, K., Ahmed, R., Frelinger, J.A. (1990). Altered Recognition of LCMV Antigen Presented on Mutant Class I Molecules. In: Egorov, I.K., David, C.S. (eds) Transgenic Mice and Mutants in MHC Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75442-5_4
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DOI: https://doi.org/10.1007/978-3-642-75442-5_4
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