Microgene Conversion in the Evolution of the MHC Class I Multigene Family
The class I gene family resides on mouse chromosome 17 and contains from 26 to 34 different loci (Hood et al., 1983). Most of these genes reside within the Qa and Tla subregions, have unknown functions, and are relatively non-polymorphic (Mellor et al., 1984; Watts et al., 1989a). However, genes residing within the H-2 region, whose products function in presenting antigenic peptides to cytotoxic T cells (CTL)(Townsend et al, 1986), exhibit extreme allelic polymorphism. Interestingly, most of the diversity displayed among class I alleles and loci is in exons 2 and 3, which encode the α1 and α2 regions of the protein (Jaulin et al., 1985).
KeywordsMajor Histocompatibility Complex Gene Conversion Selective Force Gene Conversion Event Gene Conversion Tract
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