Abstract
Studies in several laboratories have demonstrated the existence of at least six subtypes of the HLA-B27 antigen in the human population. They are designated as B*2701 to B*2706 and differ from each other by just a few amino acid changes, that are located in the peptide binding site of the molecule (López de Castro 1989). Because of its location, subtype polymorphism induces significant, sometimes critical, differences in cytotoxic T lymphocyte (CTL) recognition, so that B27 subtypes are, in spite of their structural similarity, functionally distinct alleles.
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Rojo, S., Calvo, V., López, D., Galocha, B., López de Castro, J.A. (1990). Analysis of HLA-B27-Specific T-Cell Epitopes with Site-Directed Mutants Mimicking HLA-B27 Polymorphism. In: Egorov, I.K., David, C.S. (eds) Transgenic Mice and Mutants in MHC Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75442-5_11
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DOI: https://doi.org/10.1007/978-3-642-75442-5_11
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