Hospital Experience with Bifonazole/Urea

Abstract

As the treatment of the onychomycoses still presents unsolved difficulties, such as defective penetration of topical antimycotics, immobilization and occasional onychodysplasia after nail removal, and sometimes serious side-effects during systemic therapy, the clinician is always interested in new remedies, especially if these promise a favorable activity/side-effect spectrum and the patient remains fit for work during treatment. The idea of detaching affected nails by means of appropriate chemicals is not new, although this form of treatment has never been properly carried through. Either the keratolyses were too aggressive for the surrounding healthy tissue, or ineffective due to a too low dosage, or pharmaceutically unstable. There were added difficulties with administration, resulting in poor compliance.