Clinical, Electrophysiological, and Biochemical Markers and Monoaminergic Hypotheses in Autism

  • N. Bruneau
  • C. Barthélémy
  • J. Martineau
  • J. L. Adrien
  • B. Garreau
  • J. P. Muh
  • G. Lelord


Early infantile autism, originally described by Kanner (1943), is a syndrome defined by a set of clinical features including failure to develop normal social relationships, developmental disturbances of verbal and nonverbal communication, ritualistic and compulsive behaviors, and disturbances of motility and attention.


Autistic Child Childhood Autism Rating Scale Retarded Child Autistic Subject Infantile Autism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Adrien JL, Ornitz E, Barthélémy C, Sauvage D, Lelord G (1987) The presence or absence of certain behaviors associated with infantile autism in severely retarded autistic and nonautistic retarded children and very young normal children. J Autism Dev Disord 17:407–416PubMedGoogle Scholar
  2. American Psychiatric Association (1980) Diagnostic and statistical manual of mental disorders (DSM III), 3rd ed. American Psychiatric Association, WashingtonGoogle Scholar
  3. Anderson LT, Campbell M, Grega DM, Perry R, Small AM, Green WH (1984) Haloperidol in the treatment of infantile autism: effects on learning and behavioral symptoms. Am J Psychiatry 141:1195–1202PubMedGoogle Scholar
  4. Barthélémy C, Adrien JL, Tanguay P, Garreau B, Fermanian J, Roux S, Sauvage D, Lelord G (1990) The Behavioral Summarized Evaluation (BSE): validity and reliability of a scale for the assessment of autistic behaviors. J Autism Dev Disord (in press)Google Scholar
  5. Barthélémy C, Bruneau N, Cottet-Eymard JM, Jouve J, Garreau B, Lelord G, Muh JP, Peyrin L (1988) Urinary free and conjugated catecholamines and metabolites in autistic children. J Autism Dev Disord 18:583–590PubMedGoogle Scholar
  6. Barthélémy C, Bruneau N, Jouve J, Martineau J, Muh JP, Lelord G (1989) Urinary dopamine metabolites as indicators of the responsiveness to fenfluramine treatment in children with autistic behavior. J Autism Dev Disord 19:241–254PubMedGoogle Scholar
  7. Bergman P, Escalona SK (1949) Unusual sensitivities in very young children. Psychoanal Study Child 3:333–353Google Scholar
  8. Boullin DJ, Coleman M, O’Brien RA (1970) Abnormalities in platelet 5-hydroxytryptamine efflux in patients with infantile autism. Nature 226:371–372PubMedGoogle Scholar
  9. Boullin DJ, Coleman M, O’Brien RA, Rimland B (1971) Laboratory predictions of infantile autism, based on 5-hydroxytryptamine efflux from platelets, and their correlation with the Rimland E2 scores. J Autism Child Schizophr 1:63–71PubMedGoogle Scholar
  10. Bouyer JJ, Montaron MF, Fabre-Thorpe M, Rougeul A (1986) Compulsive attentive behavior after lesion of the ventral striatum in the cat: a behavioral and electrophysiological study. Exp Neurol 92:698–712PubMedGoogle Scholar
  11. Bruneau N, Roux S, Garreau B, Lelord G (1985) Frontal auditory evoked potentials and augmenting-reducing. Electroencephalogr Clin Neurophysiol 62:364–371PubMedGoogle Scholar
  12. Bruneau N, Barthélémy C, Jouve J, Lelord G (1986) Frontal auditory evoked potential augmenting-reducing and urinary homovanillic acid. Neuropsychobiology 16:78–84PubMedGoogle Scholar
  13. Bruneau N, Garreau B, Roux S, Lelord G (1987) Modulation of auditory evoked potentials with increasing stimulus intensity in autistic children. In: Johnson RJ, Parasuraman R, Rohrbaugh JW (eds) Current trends in event-related potential research (EEG Suppl 40). Elsevier, Amsterdam, pp 584–589Google Scholar
  14. Bruneau N, Arbeille P, Dourneau MC, Garreau B, Pourcelot L, Lelord G (1989a) Evaluation du débit sanguin cérébral par Doppler transcrânien chez des enfants présentant un comportement autistique. C R Acad Sci Paris 308 III:255–260PubMedGoogle Scholar
  15. Bruneau N, Barthélémy C, Roux S, Jouve J, Lelord G (1989b) Auditory evoked potential modifications according to clinical and biochemical responsiveness to fenfluramine treatment in children with autistic behavior. Neuropsychobiology 21:48–52PubMedGoogle Scholar
  16. Bryson CQ (1970) Systematic identification of perceptual disabilities in autistic children. Percept Mot Skills 31:239–246PubMedGoogle Scholar
  17. Buchsbaum MS (1976) Self-regulation of stimulus intensity. In: Schwartz GE, Shapiro D (eds) Consciousness and self-regulation. Plenum, New York, pp 101–135Google Scholar
  18. Campbell M, Friedman E, Green WH, Collins PJ, Small AM, Breuer H (1975) Blood serotonin in schizophrenic children. A preliminary study. Int Pharmacopsychol 10:213–221Google Scholar
  19. Campbell M, Anderson LT, Small AM, Perry R, Green WH, Caplan R (1982a) The effects of haloperidol on learning and behavior in autistic children. J Autism Dev Disord 12:167–175PubMedGoogle Scholar
  20. Campbell M, Rosenbloom S, Perry, R, George AE, Kricheff II, Anderson L, Small AM, Jennings SJ (1982b) Computerized axial tomography in young autistic children. Am J Psychiatry 139:510–512PubMedGoogle Scholar
  21. Cantor DS, Thatcher RW, Hrybyk M, Kaye H (1986) Computerized EEG analysis of autistic children. J Autism Dev Disord 16:169–187PubMedGoogle Scholar
  22. Clark CR, Geffen GM, Geffen LB (1987a) Catecholamines and attention I: Animal and clinical studies. Neurosci Biobehav Rev 11:341–352PubMedGoogle Scholar
  23. Clark CR, Geffen GM, Geffen LB (1987b) Catecholamines and attention II: Pharmacological studies in normal humans. Neurosci Biobehav Rev 11:353–364PubMedGoogle Scholar
  24. Cohen DJ, Shaywitz BA, Johnson NT, Bowers MB (1974) Biogenic amines in autistic and atypical children. Cerebrospinal fluid measures of homovanillic acid and 5-hydroxyindoleacetic acid. Arch Gen Psychiatry 31:845–853PubMedGoogle Scholar
  25. Cohen DJ, Caparulo BK, Shaywitz BA, Bowers MB (1977) Dopamine and serotonin metabolism in neuropsychiatrically disturbed children: CSF homovanillic acid and 5-hydroxyindoleacetic acid. Arch Gen Psychiatry 34:545–550PubMedGoogle Scholar
  26. Coleman M (1973) Serotonin and central nervous system syndromes of childhood: a review. J Autism Child Schizophr 3:27–35PubMedGoogle Scholar
  27. Coleman M, Gillberg C (1985) The biology of the autistic syndromes. Praeger, New YorkGoogle Scholar
  28. Courchesne E (1986) A neurophysiological view of autism. In: Schopler E, Mesibov GB (eds) Neurobiological issues in autism. Plenum, New York, pp 285–324Google Scholar
  29. Courchesne E, Kilman BA, Galambos R, Lincoln AJ (1984) Autism: processing of novel auditory information assessed by event-related brain potentials. Electroencephalogr Clin Neurophysiol 59:238–248PubMedGoogle Scholar
  30. Courchesne E, Courchesne RY, Hicks G, Lincoln AJ (1985a) Functioning of the brainstem auditory pathway in non-retarded autistic individuals. Electroencephalogr Clin Neurophysiol 61:491–501PubMedGoogle Scholar
  31. Courchesne E, Lincoln AJ, Kilman BA, Galambos R (1985b) Event-related brain potential correlates of the processing of novel visual and auditory information in autism. J Autism Dev Disord 15:55–76PubMedGoogle Scholar
  32. Courchesne E, Hesselink J, Jernigan T, Yeung-Courchesne R (1987) Abnormal neuroanatomy in a non-retarded person with autism: unusual findings with magnetic resonance imaging. Arch Neurol 44:335–341PubMedGoogle Scholar
  33. Courchesne E, Yeung-Courchesne R, Press G, Jernigan TL, Hesselink JR (1988) Hypoplasia of cerebellar vermal lobules VI and VII in infantile autism. N Engl J Med 318:1349–1354PubMedGoogle Scholar
  34. Creak M, Pampiglione G (1969) Clinical and EEG studies on a group of 35 psychotic children. Dev Med Child Neurol 11:218–227PubMedGoogle Scholar
  35. Creasey H, Rumsey JM, Schwartz M, Duara R, Rapoport JL, Rapoport SI (1986) Brain morphometry in autistic men as measured by volumetric computed tomography. Arch Neurol 43:669–672PubMedGoogle Scholar
  36. Damasio AR, Maurer RG (1978) A neurological model for childhood autism. Arch Neurol 35:777–786PubMedGoogle Scholar
  37. Dawson G, Finley C, Phillips S, Lewy A (1989) A comperieson of hemisheric asymmetries in speech-related brain potentials of autistic and dysphasic children. Brain Lang 37:26–41PubMedGoogle Scholar
  38. Deutsch SI (1986) Rationale for the administration of opiate antagonists in treating infantile autism. Am J Ment Defic 90:631–635PubMedGoogle Scholar
  39. Elliott GR, Ciaranello RD (1986) Neurochemical hypotheses of childhood psychoses. In: Schopler E, Mesibov S (eds) Neurobiological issues in autism. Plenum, New York, pp 245–261Google Scholar
  40. Freeman BJ, Ritvo ER, Guthrie D, Schroth P, Ball J (1978) The Behavior Observation Scale for autism: initial methodology, data analysis and preliminary findings on 89 children. J Am Acad Child Psychiatry 17:576–588PubMedGoogle Scholar
  41. Garreau B, Barthélémy C, Domenech J, Sauvage D, Muh JP, Lelord G, Callaway E (1980) Troubles du métabolisme de la dopamine chez des enfants ayant un comportement autistique. Résultats des examens cliniques et des dosages urinaires de l’acide homovanilique. Acta Psychiatr Belg 80:249–265PubMedGoogle Scholar
  42. Garreau B, Tanguay P, Roux S, Lelord G (1984) Etude des potentiels évoqués auditifs du tronc cérébral chez l’enfant normal et chez l’enfant autistique. Rev Electroencephalogr Neurophysiol Clin 14:25–31PubMedGoogle Scholar
  43. Garreau B, Barthélémy C, Martineau J, Bruneau N, Lelord G (1985) Aspects électrophysiologiques dans l’autisme de l’enfant. Encephale 11:145–155PubMedGoogle Scholar
  44. Garreau B, Barthélémy C, Jouve J, Bruneau N, Muh JP, Lelord G (1988) Urinary homovanillic acid levels of autistic children. Dev Med Child Neurol 30:93–98PubMedGoogle Scholar
  45. Gillberg C, Rosenhall H, Johansson E (1983a) Auditory brainstem responses in childhood psychosis. J Autism Dev Disord 13:181–195PubMedGoogle Scholar
  46. Gillberg C, Svennerholm L, Hamilton-Hellberg C (1983b) Childhood psychosis and monoamine metabolites in spinal fluid. J Autism Dev Disord 13:383–396PubMedGoogle Scholar
  47. Gillberg C, Terenius L, Lonnerholm G (1985) Endorphin activity in childhood psychosis. Arch Gen Psychiatry 42:780–783PubMedGoogle Scholar
  48. Glowinski J (1981) Present knowledge on the properties of the mesocortico-frontal dopaminergic neurons. In: Mathysse S (ed) Psychiatry and the biology of the human brain: a symposium dedicated to Seymour HS. Kety. Elsevier, New York, pp 139–164Google Scholar
  49. Gold MS, Gold JR (1975) Autism and attention: theoretical considerations and a pilot study using set reaction time. Child Psychiatry Hum Dev 6:68–80PubMedGoogle Scholar
  50. Goldfarb W (1963) Self-awareness in schizophrenic children. Arch Gen Psychiatry 8:47–60Google Scholar
  51. Hanley HG, Stahl SM, Freedman D (1977) Hyperserotonemia and amine metabolites in autistic and retarded children. Arch Gen Psychiatry 34:521–531PubMedGoogle Scholar
  52. Hetzler BE, Griffin JL (1981) Infantile autism and the temporal lobe of the brain. J Autism Dev Disord 11:317–330PubMedGoogle Scholar
  53. Hoffmann WL, Prior MR (1982) Neuropsychological dimensions of autism in children: a test of the hemispheric dysfunction hypothesis. J Clin Neuropsychol 4:27–41PubMedGoogle Scholar
  54. Hokfelt T, Ljungdahl A, Fuxe K, Johansson O (1974) Dopamine nerve terminals in the rat limbic cortex: aspects of the dopamine hypothesis of schizophrenia. Science 184:177–179PubMedGoogle Scholar
  55. James AL, Barry RJ (1980) Respiratory and vascular responses to simple visual stimuli in autistics, retardates and normals. Psychophysiology 17:541–547PubMedGoogle Scholar
  56. Kanner L (1943) Autistic disturbances of affective contact. Nerv Child 2:217–250Google Scholar
  57. Knight R (1984) Decreased response to novel stimuli after prefrontal lesions in man. Electroencephalogr Clin Neurophysiol 59:9–20PubMedGoogle Scholar
  58. Kootz JP, Cohen DJ (1981) Modulation of sensory intake in autistic children. J Am Acad Child Psychiatry 20:692–701PubMedGoogle Scholar
  59. Kootz JP, Marinelli B, Cohen DJ (1982) Modulation of response to environmental stimulation in autistic children. J Autism Dev Disord 12:185–193PubMedGoogle Scholar
  60. Krug DA, Arick JR, Almond PJ (1980) Behavior checklist for identifying severely handicapped individuals with high levels of autistic behavior. J Child Psychol Psychiatry 21:221–229PubMedGoogle Scholar
  61. Lake CR, Ziegler MG, Murphy DL (1977) Increased norepinephrine levels and decreased ß-hydroxylase activity in primary autism. Arch Gen Psychiatry 34:553–556PubMedGoogle Scholar
  62. Leddet I, Larmande C, Barthélémy C, Chalon F, Sauvage D, Lelord G (1986) Comparison of clinicalGoogle Scholar
  63. Lelord G, Laffont F, Jusseaume P, Stephant JL (1973) Comparative study of conditioning of averaged evoked responses by coupling sound and light in normal and autistic children. Psychophysiology 10:415–427PubMedGoogle Scholar
  64. Lelord G, Callaway E, Muh JP, Arlot JC, Sauvage D, Garreau B, Domenech J (1978) L’acide homovanilique urinaire et ses modifications par ingestion de vitamine B6: Exploration fonctionnelle dans l’autisme de l’enfant? Rev Neurol 134:797–801PubMedGoogle Scholar
  65. Lelord G, Muh JP, Barthélémy C, Martineau J, Garreau B (1981) Effects of pyridoxine and magnesium on autistic symptoms—initial observations. J Autism Dev Disord 11:219–230PubMedGoogle Scholar
  66. Lelord G, Barthélémy C, Sauvage D, Boiron M, Adrien JL, Hameury L (1987) Thérapeutiques d’echange et de dévelopement dans l’autisme de l’enfant, Bases physiologiques. Bull Acad Natl Med (Paris) 171:137–143Google Scholar
  67. Le Moal M, Stinus L, Simon H, Tassin JP, Thierry AM, Blanc G, Glowinski J, Cardo B (1977) Behavioral effects of a lesion in the ventral mesencephalic tegmentum: evidence for involvement of A10 dopaminergic neurons. In: Costa E, Gessa GL (eds) Non-striatal dopaminergic neurons. Adv Biochem Psychopharmacol 16:237–245Google Scholar
  68. Luria AR (1966) Higher cortical functions in man. Basic Books, New YorkGoogle Scholar
  69. Maas JW, Hattox SE, Martin DM, Landis DH (1979) A direct method for determining dopamine synthesis and output of dopamine metabolites from brain in awake animals. J Neurochem 32:839–843PubMedGoogle Scholar
  70. Maas JW, Hattok SE, Greene NM, Landis DH (1980) Estimates of dopamine and serotonin synthesis by the awake human brain. J Neurochem 34:1547PubMedGoogle Scholar
  71. Martineau J, Laffont F, Bruneau N, Roux S, Lelord G (1980) Event-related potentials evoked by sensory stimulation in normal, mentally retarded and autistic children. Electroencephalogr Clin Neurophysiol 48:140–153PubMedGoogle Scholar
  72. Martineau J, Barthélémy C, Garreau B, Lelord G (1985) Vitamin B6, magnesium and combined B6-Mg: therapeutic effects in childhood autism. Biol Psychiatry 20:467–478PubMedGoogle Scholar
  73. Martineau J, Garreau B, Roux S, Lelord G (1987) Auditory evoked responses and their modifications during conditioning paradigm in autistic children. J Autism Dev Disord 17:525–539PubMedGoogle Scholar
  74. Morton-Evans A, Hensley R (1978) Paired associate learning in early infantile autism and receptive developmental aphasia. J Autism Child Schizophr 8:61–69PubMedGoogle Scholar
  75. Muh JP, Barthélémy C, Jouve J, Martineau J, Mariotte N, Bruneau N (1987) Les monoamines urinaires dans l’autisme de l’enfant. In: Grémy F, Tomkiewicz S, Ferrari P, Lelord G (eds) Autisme infantile/Infantile autism. INSERM, pp 129–136 (Colloque INSERM, vol. 146)Google Scholar
  76. Muller HF (1985) Prefrontal cortex dysfunction as a common factor in psychosis. Acta Psychiatr Scand 71:431–440PubMedGoogle Scholar
  77. Niéoullon A, Cheramy A, Glowinski J (1978) Release of dopamine in both caudate nuclei and both substantiae nigrae in response to unilateral stimulation of cerebellum in the cat. Brain Res 148:143–152PubMedGoogle Scholar
  78. Niwa S, Ohta M, Yamazaki K (1983) P300 and stimulus evaluation process in autistic subjects. J Autism Dev Disord 13:33–42PubMedGoogle Scholar
  79. Novick B, Kurtzberg D, Vaughan HG (1979) An electrophysiologic indication of defective information storage in childhood autism. Psychiatry Res 1:101–108PubMedGoogle Scholar
  80. Novick B, Vaughan HG, Kurtzberg D, Simson R (1980) An electrophysiologic indication of auditory processing defects in autism. Psychiatry Res 3:107–114PubMedGoogle Scholar
  81. Ornitz EM (1969) Disorders of perception common to early infantile autism and schizophrenia. Compr Psychiatry 10:259–274PubMedGoogle Scholar
  82. Ornitz EM (1974) The modulation of sensory input and motor output in autistic children. J Autism Child Schizophr 4:197–215PubMedGoogle Scholar
  83. Ornitz EM (1983) The functional neuroanatomy of infantile autism. Int J Neurosci 19:85–124PubMedGoogle Scholar
  84. Ornitz EM (1985) Neurophysiology of infantile autism. J Am Acad Child Psychiatry 24:251–262PubMedGoogle Scholar
  85. Ornitz EM, Ritvo ER (1968) Perceptual inconstancy in early infantile autism. Arch Gen Psychiatry 18:76–98PubMedGoogle Scholar
  86. Ornitz EM, Tanguay PE, Lee JCM, Ritvo ER, Sivertsen B, Wilson C (1972) Effects of stimulus interval on the auditory evoked response during sleep in autistic children. J Autism Child Schizophr 2:1450–1456Google Scholar
  87. Ornitz EM, Mo A, Olson ST, Walter DO (1980) Influence of click sound pressure direction on brainstem responses in children. Audiology 19:245–254PubMedGoogle Scholar
  88. Paasonen MK (1968) Platelet 5-hydroxytryptamine as a model in pharmacology. Ann Med Exp Biol Fenn 46:416PubMedGoogle Scholar
  89. Parks SI (1983) The assessment of autistic children: a selective review of available instruments. J Autism Dev Disord 13:255–267PubMedGoogle Scholar
  90. Petrie A (1958) Effects of chlorpromazine and of brain lesions on personality. In: Pennes HD (ed) Psychopharmacology. Harper, New York, pp 99–115Google Scholar
  91. Peyrin L, Cottet-Emard JM, Javoy F, Agid Y, Herbet A, Glowinski J (1978) Long term effects of unilateral 6-hydroxydopamine destruction of the dopaminergic nigrostriatal pathway on the urinary excretion of catecholamines (dopamine, norepinephrine, epinephrine) and their metabolites in the rat. Brain Res 143:567–572PubMedGoogle Scholar
  92. Peyrin L, Simon H, Cottet-Emard JM, Bruneau N, Le Moal M (1982) 6-Hydroxydopamine lesions of dopaminergic A10 neurons. Long-term effects on the urinary excretion of free and conjugated catecholamines and their metabolites in the rat. Brain Res 235:363–369PubMedGoogle Scholar
  93. Pletcher A (1968) Metabolism, transfer and storage of 5HT in blood platelets. Br J Pharmacol 32:1–16Google Scholar
  94. Prior MR, Tress B, Hoffman NL, Boldt D (1984) Computed tomographic study of children with classic autism. Arch Neurol 41:482–484PubMedGoogle Scholar
  95. Rimland B (1971) The differentiation of childhood psychoses: an analysis of checklists for 2218 psychotic children. J Autism Child Schizophr 1:161–174PubMedGoogle Scholar
  96. Ritvo ER, Yuwiler A, Geller E, Ornitz EM, Saeger K, Plotkin S (1970) Increased blood serotonin and platelets in early infantile autism. Arch Gen Psychiatry 23:566–572PubMedGoogle Scholar
  97. Ritvo ER, Freeman BJ, Yuwiler A, Geller A, Schroth P, Yokata A, Mason-Brothers A, August GJ, Klykylo W, Leventhal B, Lewis K, Piggott L, Realmuto G, Stubbs EG, Umansky R (1986) Fenfluramine treatment of autism: UCLA collaborative study of 81 patients at nine medical centers. Psychopharmacology 22:133–140Google Scholar
  98. Rosenbloom S, Campbell M, George AE, Kricheff II, Taleporos E, Anderson L, Reuben RN, Korein J (1984) High resolution CT scanning in infantile autism: a quantitative approach. J Am Acad Child Psychiatry 23:72–77PubMedGoogle Scholar
  99. Rosenblum SM, Arick JR, Krug DA, Stubbs EG, Young NB, Pelson RO (1980) Auditory brainstem evoked responses in autistic children. J Autism Dev Disord 10:215–225PubMedGoogle Scholar
  100. Roux S (1981) Aspects electrophysiologiques du conditionnement des potentials évoqués par des stimulations sensorielles chez l’homme. Doctoral thesis, University of PoitiersGoogle Scholar
  101. Rumsey JM, Grimes AM, Pikus AM, Duara R, Ismond DR (1984) Auditory brainstem responses in pervasive developmental disorders. Biol Psychiatry 19:1403–1418PubMedGoogle Scholar
  102. Rumsey JM, Duara R, Grady C, Rapoport JL, Margolin RA, Rapoport SI, Cutler NR (1985) Brain metabolism in autism: resting cerebral glucose utilization rates as measured with positron emission tomography. Arch Gen Psychiatry 42:448–455PubMedGoogle Scholar
  103. Ruttenberg BA, Dratman ML, Fraknoi J, Wenar C (1966) An instrument for evaluating autistic children. J Am Acad Child Psychiatry 5:453–478PubMedGoogle Scholar
  104. Ruttenberg BA, Kalish BI, Wenar C, Wolf EG (1977) Behavior rating instrument for autistic and other atypical children. Developmental Center for Autistic Children, PhiladelphiaGoogle Scholar
  105. Rutter M (1979) Language, cognition and autism. In: Katzman R (ed) Congenital and acquired cognitive disorders. Raven, New York, pp 247–264Google Scholar
  106. Sahley TL, Panksepp J (1987) Brain opioids and autism: an updated analysis of possible linkages, J Autism Dev Disord 17:201–216PubMedGoogle Scholar
  107. Sandyk R (1986) Further speculations on possible dopamine-opioid link in autism. J Autism Dev Disord 16:89–90PubMedGoogle Scholar
  108. Schain RJ, Freedman DX (1961) Study on 5-hydroxyindole metabolism in autistic and mentally retarded children. J Pediatr 58:315–320PubMedGoogle Scholar
  109. Schopler E, Reichler RJ, De Vellis RF, Daly K (1980) Toward objective classification of childhood autism: childhood autism rating scale (CARS). J Autism Dev Disord 10:91–103PubMedGoogle Scholar
  110. Sedvall G, Farde L, Persson A, Wiesel FA (1986) Imaging of neurotransmitter receptors in the living human brain. Arch Gen Psychiatry 43:995–1005PubMedGoogle Scholar
  111. Sherman M, Ruth N, Shapiro TH (1984) Regional cerebral blood flow in autism. J Autism Dev Disord 14:439–446PubMedGoogle Scholar
  112. Simon H, Le Moal M (1985) Influences des neurones dopaminergiques du mésencéphale sur les processus d’attention et d’intention. Psychologie Médicale 17:939–945Google Scholar
  113. Simon H, Le Moal M, Calas A (1979) Efferents and afferents of the ventral tegmental-A10 region studied after local injection of 3H leucine and horseradish peroxidase. Brain Res 178:17–40PubMedGoogle Scholar
  114. Simon H, Scatton B, Le Moal M (1980) Dopaminergic A10 neurons are involved in cognitive functions. Nature 286:150–151PubMedGoogle Scholar
  115. Skoff BF, Mirsky AF, Turner D (1980) Prolonged brainstem transmission time in autism. Psychiatry Res 2:157–166PubMedGoogle Scholar
  116. Small JG (1971) Sensory evoked responses of autistic children. In: Churchill DW, Alpern GD, De Myer MK (eds) Infantile autism. Thomas, Springfield, pp 224–242Google Scholar
  117. Small JG, De Myer MK, Milstein V (1971) CNV responses of autistic and normal children. J Autism Child Schizophr 1:215–231PubMedGoogle Scholar
  118. Snider SR, Snider RS (1977) Alterations in forebrain catecholamine metabolism produced by cerebellar lesions in the rat. J Neural Transm 40:115–128PubMedGoogle Scholar
  119. Student M, Sohmer H (1978) Evidence from auditory nerve and brainstem evoked responses for an organic brain lesion in children with autistic traits. J Autism Dev Disord 8:13–20 (Erratum 9:309)Google Scholar
  120. Swann AC, Maas JW, Hattox SE, Landis DH (1980) Catecholamine metabolites in human plasma as indices of brain function: effects of debrisoquin. Life Sci 25:1857–1862Google Scholar
  121. Takahashi S, Kanai H, Miyamoto Y (1976) Reassessment of elevated serotonin levels in blood platelets in early infantile autism. J Autism Child Schizophr 6:317–326PubMedGoogle Scholar
  122. Tanguay PE (1976) Clinical and electrophysiological research. In: Ritvo ER (ed) Autism: diagnosis, current research and management. Spectrum, New York, pp 75–84Google Scholar
  123. Tanguay PE, Ornitz EM, Forsythe AB, Ritvo ER (1976) Rapid eye movement (REM) activity in normal and autistic children during REM sleep. J Autism Child Schizophr 6:275–288PubMedGoogle Scholar
  124. Tanguay P, Edwards RM, Buchwald J, Schwafel J, Allen V (1982) Auditory brainstem evoked responses in autistic children. Arch Gen Psychiatry 39:174–180PubMedGoogle Scholar
  125. Taylor MJ, Rosenblatt B, Linschoten L (1982) Electrophysiological study of the auditory system in autistic children. In: Rothenberger A (ed) Event-related potentials in children. Elsevier, Amsterdam, pp 379–386 (Developments in neurology, vol. 6)Google Scholar
  126. Thierry AM, Blanc G, Sobe A, Stinus L, Glowinski J (1973) Dopaminergic terminals in the rat cortex. Science 182:499–501PubMedGoogle Scholar
  127. Tsai L, Stewart MA (1982) Handedness and EEG correlation in autistic children. Biol Psychiatry 17:595–598PubMedGoogle Scholar
  128. Walsh KW (1978) Neuropsychology: a clinical approach. Churchill Livingstone, EdinburghGoogle Scholar
  129. Walter WG, Aldridge VJ, Cooper R, O’Gorman G, McCallum C, Winter AL (1971) Neurophysiological correlates of apparent defects of sensorimotor integration in autistic children. In: Alpern GD, De Myer MK (eds) Infantile autism. Thomas, Springfield, pp 265–276Google Scholar
  130. Weizman R, Weizman A, Tyano S, Szekely G, Weissman BA, Sarne Y (1984) Humoral-endorphin blood levels in autistic, schizophrenic, and healthy subjects. Psychopharmacology 82:368–370PubMedGoogle Scholar
  131. Young JG, Cohen DJ, Brown SL, Caparulo BK (1978) Decreased urinary free catecholamines in childhood autism. J Am Acad Child Psychiatry 17:671–678PubMedGoogle Scholar
  132. Young JG, Cohen DJ, Caparulo BK, Brown SL, Maas JW (1979) Decreased 24 hours urinary MHPG in childhood autism. Am J Psychiatry 136:1056–1057Google Scholar
  133. Young JG, Cohen DJ, Kavanagh ME, Landis HD, Shaywitz BA, Maas JW (1981) Cerebrospinal fluid, plasma, and urinary MHPG in children. Life Sci 28:2837–2845PubMedGoogle Scholar
  134. Young JG, Kavanagh ME, Anderson GM, Shaywitz BA, Cohen DJ (1982) Clinical neurochemistry of autism and associated disorders. J Autism Dev Disord 12:147–165PubMedGoogle Scholar
  135. Yuwiler A, Freedman DX (1986) Neurotransmitter research in autism. In: Schopler E, Mesibov GB (eds) Neurobiological issues in autism. Plenum, New York, pp 263–284Google Scholar
  136. Yuwiler A, Ritvo E, Geller E, Glousman R, Schneiderman G, Matsuno D (1975) Uptake and efflux of serotonin from platelets of autistic and nonautistic children. J Autism Dev Disord 5:83–98Google Scholar

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© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • N. Bruneau
  • C. Barthélémy
  • J. Martineau
  • J. L. Adrien
  • B. Garreau
  • J. P. Muh
  • G. Lelord

There are no affiliations available

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