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Focal Necrosis: Primary Event in the Pathogenesis of Chronic Pancreatitis?

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Chronic Pancreatitis

Abstract

Pancreatic pseudocyst, the residual of focal fat necrosis in acute pancreatitis [11, 12], is also a common finding in chronic pancreatitis [1, 2, 17, 20]. Yet its significance for the pathogenesis of chronic pancreatitis has been neglected for many years, owing to the widely accepted view that acute and chronic pancreatitis differ in etiology and pathogenesis [18]. Here we will briefly review the pathology of focal necrosis and pseudocysts in chronic pancreatitis and discuss their possible role in the pathogenesis of the disease.

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References

  1. Ammann RW, Akovbiantz A, Largiader F, Schueler G (1984) Course and outcome of chronic pancreatitis. Longitudinal study of a mixed medical-surgical series of 245 patients. Gastroenterology 86:820–828

    PubMed  CAS  Google Scholar 

  2. Ammann RW, Buehler H, Bruehlmann W, Kehl O, Muench R, Stamm B (1986) Acute (nonprogressive) alcoholic pancreatitis: prospective longitudinal study of 144 patients with recurrent alcoholic pancreatitis. Pancreas 1:195–203

    Article  PubMed  CAS  Google Scholar 

  3. Becker V (1984) Chronische Pankreatitis. Klinische Morphologic In: Bartelheimer H, Kühn HA, Becker V, Stelzner F (eds) Gastroenterologie und Stoffwechsel, vol 21. Thieme, Stuttgart

    Google Scholar 

  4. Berens JJ, Baggenstoss AH, Gray HK (1954) Ductal changes in chronic pancreatitis. AMA Arch Surgery 68:723–733

    CAS  Google Scholar 

  5. Bourliere M, Sarles H (1989) Pancreatic cysts and pseudocysts associated with acute and chronic pancreatitis. Dig Dis Sci 34:343–348

    Article  PubMed  CAS  Google Scholar 

  6. Edmondson HA, Bullock WK, Mehl JW (1950) Chronic pancreatitis and lithiasis. II. Pathology and pathogenesis of pancreatic lithiasis. Am J Pathol 26:37–49

    PubMed  CAS  Google Scholar 

  7. Gambill EE, Comfort MW, Baggenstoss AH (1948) Chronic relapsing pancreatitis. An analysis of 27 cases associated with disease of the biliary tract. Gastroenterology 11:1–33

    PubMed  CAS  Google Scholar 

  8. Gyr K, Heitz PU, Beglinger C (1984) Pancreatitis. In: Klöppel G, Heitz PU (eds) Pancreatic pathology. Livingstone, Edinburgh, pp 44–72

    Google Scholar 

  9. Klöppel G (1986) Pathomorphology of chronic pancreatitis. In: Malfertheiner, Ditschuneit H (eds) Diagnostic procedures in pancreatic disease. Springer, Berlin Heidelberg New York, pp 135–139

    Chapter  Google Scholar 

  10. Klöppel G, Maillet B (1990) Pseudocysts in chronic pancreatitis: a morphological analysis of 57 resection specimens and 9 autopsy pancreata. Pancreas (in press)

    Google Scholar 

  11. Klöppel G, von Gerkan R, Dreyer T (1984) Pathomorphology of acute pancreatitis. Analysis of 367 autopsy cases and 3 surgical specimens. In: Gyr KE, Singer MV, Sarles H (eds) Pancreatitis — concepts and classification. Excerpta Medica, Amsterdam, pp 29–35

    Google Scholar 

  12. Klöppel G, Dreyer T, Willemer S, Kern HF, Adler G (1986) Human acute pancreatitis: its pathogenesis in the light of immunocytochemical and ultrastructural findings in acinar cells. Virchows Arch [Pathol Anat] 409:791–803

    Article  Google Scholar 

  13. Konishi K, Izumi R, Kato O, Yamaguchi A, Miyazaki I (1981) Experimental pancreatolithiasis in the dog. Surgery 89:687–691

    PubMed  CAS  Google Scholar 

  14. Sarles H (1965) Pancreatitis. Symposium Marseille 1963. Karger, Basel

    Google Scholar 

  15. Sarles H, Muratore R, Sarles JC (1961) Etude anatomique des pancréatites chronique de l’adulte. Sem Hop Paris 25:1507–1522

    Google Scholar 

  16. Sarles H, Martin M, Camatte R, Sarles JC (1963) Le démembrement des pancréatites: les pseudokystes des pancréatites aigues et des pancréatites chroniques. Presse Med 5:237–240

    Google Scholar 

  17. Sarles H, Sarles JC, Camatte R, Muratore R, Gaini M, Guien C, Pastor J, Le Roy F (1965) Observations on 205 confirmed cases of acute pancreatitis, recurring pancreatitis, and chronic pancreatitis. Gut 6:545–559

    Article  PubMed  CAS  Google Scholar 

  18. Sarles H, Sahel J, Staub JL, Bourry J, Lauguer R (1979) Chronic pancreatitis. In: Howat HT, Sarles H (eds) The exocrine pancreas. Saunders, Philadelphia, pp 402–439

    Google Scholar 

  19. Stolte M (1984) Chronische Pankreatitis: Morphologie, Pankreatographie, Differentialdiagnose. perimed, Erlangen

    Google Scholar 

  20. Uys CJ, Bank S, Marks IN (1973) The pathology of chronic pancreatitis in Cape Town. Digestion 9:454–468

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pathology, Academic Hospital, Free University of Brussels, Laarbeeklaan 101, B-1090, Brussels, Belgium

    G. Klöppel

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  1. G. Klöppel
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Editors and Affiliations

  1. Department of Surgery, University of Ulm, Steinhövelstrasse 9, D-7900, Ulm, W.-Germany

    H. G. Beger M.D.  & M. Büchler M.D.  & 

  2. Department of Internal Medicine II, University of Ulm, Robert-Koch-Strasse 8, D-7900, Ulm, W.-Germany

    H. Ditschuneit M.D.  & P. Malfertheiner M.D.  & 

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© 1990 Springer-Verlag Berlin Heidelberg

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Klöppel, G. (1990). Focal Necrosis: Primary Event in the Pathogenesis of Chronic Pancreatitis?. In: Beger, H.G., Büchler, M., Ditschuneit, H., Malfertheiner, P. (eds) Chronic Pancreatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75319-0_9

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  • DOI: https://doi.org/10.1007/978-3-642-75319-0_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75321-3

  • Online ISBN: 978-3-642-75319-0

  • eBook Packages: Springer Book Archive

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