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Influence of Intestinal Protease Inhibition on Pancreatic Feedback Regulation

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Book cover Chronic Pancreatitis

Abstract

Exocrine pancreatic secretion is dependent on the amount and activity of pancreatic enzymes released into the duodenum. This feedback regulation of exocrine pancreatic secretion was first described in the rat by Green and Lyman [1]. The exclusion of bile-pancreatic juice from the proximal small intestine of the rat caused a dramatic stimulation of pancreatic secretion. The exclusion of pancreatic juice alone had the same stimulatory effect. In a further study progressively increasing percentages of pancreatic juice were diverted from the intestine [2]. These experiments were performed to determine the relationship between the percentage of pancreatic secretion diverted from the intestine and pancreatic secretion. Return of only 5% of the secreted material into the duodenum caused a 50% reduction of pancreatic secretion. Pancreatic secretion was almost completely stopped when 10% of pancreatic juice secreted was returned to the intestine.

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, Division of Gastroenterology, Philipps University of Marburg, Baldingerstrasse, D-3550, Marburg, Germany

    M. Reinshagen

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  1. G. Adler
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  2. M. Reinshagen
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Editors and Affiliations

  1. Department of Surgery, University of Ulm, Steinhövelstrasse 9, D-7900, Ulm, W.-Germany

    H. G. Beger M.D.  & M. Büchler M.D.  & 

  2. Department of Internal Medicine II, University of Ulm, Robert-Koch-Strasse 8, D-7900, Ulm, W.-Germany

    H. Ditschuneit M.D.  & P. Malfertheiner M.D.  & 

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© 1990 Springer-Verlag Berlin Heidelberg

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Adler, G., Reinshagen, M. (1990). Influence of Intestinal Protease Inhibition on Pancreatic Feedback Regulation. In: Beger, H.G., Büchler, M., Ditschuneit, H., Malfertheiner, P. (eds) Chronic Pancreatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75319-0_22

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  • DOI: https://doi.org/10.1007/978-3-642-75319-0_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75321-3

  • Online ISBN: 978-3-642-75319-0

  • eBook Packages: Springer Book Archive

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