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Peptidergic Innervation in Chronic Pancreatitis

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Chronic Pancreatitis

Abstract

The reason for the generation and continuation of chronic pain in chronic pancreatitis is unclear [6, 10, 11, 13, 61, 117]. Current concepts of the neurobiology of pain point to the possible role of various neuropeptides in pain processing and inflammation [8, 29, 32, 33, 44, 60, 64, 65, 68, 79, 104, 112]. A key function has been ascribed to the proinflammatory and pronociceptive peptides of the tachykininin (TK) family (8, 44, 104, 109]. That the tachykinin substance P (SP) may be involved in chronic inflammatory and painful disease of the gastrointestinal system is evidenced by a selective increase in the density of tachykinin receptors in the bowels of patients suffering from Crohn’s disease and ulcerative colitis [62, 63, 64].

Supported by the German Research Foundation

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Authors and Affiliations

  1. Department of Anatomy, University of Mainz, Saarstrasse 19-21, D-6500, Mainz, Germany

    E. Weihe, S. Müller & H. J. Zentel

  2. Department of General Surgery, University of Ulm, Steinhövelstrasse 9, D-7900, Ulm, Germany

    M. Büchler & H. Friess

  3. College Department of Pharmacy, University of Shizuoka, 395 Yada, Shizuoka-shi, Shizuoka-ken, 422, Japan

    N. Yanaihara

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  1. E. Weihe
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  2. M. Büchler
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  3. S. Müller
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  4. H. Friess
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  5. H. J. Zentel
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  6. N. Yanaihara
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Editors and Affiliations

  1. Department of Surgery, University of Ulm, Steinhövelstrasse 9, D-7900, Ulm, W.-Germany

    H. G. Beger M.D.  & M. Büchler M.D.  & 

  2. Department of Internal Medicine II, University of Ulm, Robert-Koch-Strasse 8, D-7900, Ulm, W.-Germany

    H. Ditschuneit M.D.  & P. Malfertheiner M.D.  & 

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© 1990 Springer-Verlag Berlin Heidelberg

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Weihe, E., Büchler, M., Müller, S., Friess, H., Zentel, H.J., Yanaihara, N. (1990). Peptidergic Innervation in Chronic Pancreatitis. In: Beger, H.G., Büchler, M., Ditschuneit, H., Malfertheiner, P. (eds) Chronic Pancreatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75319-0_11

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  • DOI: https://doi.org/10.1007/978-3-642-75319-0_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75321-3

  • Online ISBN: 978-3-642-75319-0

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