Morphology of Nerves in Chronic Pancreatitis and the Interrelationship with Inflammatory Tissue
Chronic pancreatitis causes profound changes to occur in the makeup of the pancreas. There is functional and morphological regression of the exocrine parenchyma. Acinar cells in affected areas contain fewer or no zymogen granules; the cells decrease in height. The result of this reversion is tubular complexes, which are derived from a combination of acini and small ducts, but which have the appearance of a collection of ducts . These areas are sometimes interpreted as resulting from ductular proliferation, but there is a notable paucity of mitoses. The acinar tissue disappears with time. Some of the loss comes about by a process which has been termed apoptosis because the apical part of the acinar cell is sloughed off. Some of the cells simply disintegrate and become part of the amorphous material which may be drained away by patent ducts or retained in the connective tissue space.
KeywordsPancreatitis Mast FluoroGold
Unable to display preview. Download preview PDF.
- 3.Bockman DE (1987) Gut-associated macrophages. In: Brostoff J, Challacombe SJ (eds) Food allergy and intolerance. Baillière Tindall, London, pp 67–87Google Scholar
- 4.Bockman DE (1988) Systems underlying involvement of the duodenum in pancreatic disease. Pancreas 3:592Google Scholar
- 8.Frey CF (1973) Ninety-five percent pancreatectomy. In: Carey LC (ed) The pancreas. Mosby, St Louis, pp 202–229Google Scholar
- 9.Keith RG, Keshavjee SH, Kerenyi NR (1982) Neuropathology of chronic pancreatitis in humans. Can J Surg 28:207–211Google Scholar
- 10.Kirchgessner AL, Gershon MD (1989) Innervation of the rat’s pancreas: analysis of direct projections from neurons in myenteric ganglia of the duodenum and stomach and intrapancreatic ganglia. Gastroenterology 96:A258Google Scholar
- 11.Odaira C, Koizumi M, Sawai T (1987) Quantitative study on tissue mast cells in pancreatic disease. Digestion 38:50Google Scholar
- 14.White TT (1982) Pain. In: Bradley EL III (ed) Complications of pancreatitis. Saunders, Philadelphia, pp 203–222Google Scholar