Morphology of Nerves in Chronic Pancreatitis and the Interrelationship with Inflammatory Tissue
Chronic pancreatitis causes profound changes to occur in the makeup of the pancreas. There is functional and morphological regression of the exocrine parenchyma. Acinar cells in affected areas contain fewer or no zymogen granules; the cells decrease in height. The result of this reversion is tubular complexes, which are derived from a combination of acini and small ducts, but which have the appearance of a collection of ducts . These areas are sometimes interpreted as resulting from ductular proliferation, but there is a notable paucity of mitoses. The acinar tissue disappears with time. Some of the loss comes about by a process which has been termed apoptosis because the apical part of the acinar cell is sloughed off. Some of the cells simply disintegrate and become part of the amorphous material which may be drained away by patent ducts or retained in the connective tissue space.
KeywordsChronic Pancreatitis Acinar Cell Enteric Nervous System Zymogen Granule Sympathetic Fiber
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