Is Nonulcer Dyspepsia Improved by Treating Helicobacter pylori Infection?

  • A. T. R. Axon
Conference paper

Abstract

Clinical research in nonulcer dyspepsia (NUD) is not straightforward. Reported studies show variation in the definition of NUD, the population groups studied, the endpoints assessed and symptoms evaluated. In attempting to give an overview of the benefit of treating Helicobacter pylori (HP) in this condition it is relevant first to consider these aspects.

Keywords

Placebo Bismuth Erythromycin Gastritis Salicylate 

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References

  1. 1.
    Working Party Report (1988) Management of dyspepsia. Lancet I:576–579Google Scholar
  2. 2.
    McNulty CAM, Gearty JC, Crump B, et al. (1986) Campylobacter pyloridis and associated gastritis: investigator blind, placebo controlled trial of bismuth salicylate and erythromycin ethylsuccinate. Br Med J 293:645–649.CrossRefGoogle Scholar
  3. 3.
    Lambert JR, Borromeo M, Korman MG, Hansky J (1987) Role of Campylobacter pyloridis in non-ulcer dyspepsia — a randomized controlled study. Gastroenterology 92 (5/2): 1488.Google Scholar
  4. 4.
    Borody T, Hennessy W, Daskalopoulos G, Carrick J, Hazell S (1987) Double blind trial of DeNol in nonulcer dyspepsia associated with Campylobacter pyloridis gastritis. Gastroenterology 92 (5/2): 1324.Google Scholar
  5. 5.
    Rokkas T, Pursey C, Uzoechina E, et al. (1988) Non-ulcer dyspepsia short term De-Nol therapy: a placebo controlled trial with particular references to the role of Campylobacter pylori. Gut 29:1386–1391.PubMedCrossRefGoogle Scholar
  6. 6.
    Kang JY, Tay HH, Wee A, Guan R, Math MV, Yap I The effect of colloidal bismuth subcitrate on symptoms and gastric histology in non-ulcer dyspepsia — a double-blind placebocontrolled study.Google Scholar
  7. 7.
    Loffeld RJLF, Potters HVJP, Stobberingh E, Flendrig JA, van Spreeuwel JP, Arends JW (1989) Campylobacter associated gastritis in patients with non-ulcer dyspepsia: a double blind placebo controlled trial with colloidal bismuth subcitrate. Gut 30:1206–1212.PubMedCrossRefGoogle Scholar
  8. 8.
    Shallcross TM, Rathbone BJ, Heatley RV (1989) Campylobacter pylori and non-ulcer dyspepsia. In: Rathbone BJ, Heatley RV (eds) Campylobacter pylori and gastroduodenal disease. Blackwell, Oxford, pp 155–166.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • A. T. R. Axon
    • 1
  1. 1.Gastroenterology UnitThe General InfirmaryLeedsUK

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