Skip to main content
SpringerLink
Log in

Relationship Between Helicobacter pylori and Gastroduodenal Physiology: Acid Secretion and Pepsinogens

  • Conference paper
Book cover Helicobacter pylori, Gastritis and Peptic Ulcer

  • 170 Accesses

Abstract

It is now accepted that Helicobacter pylori (H. pylori) causes type B gastritis. Apart from its putative role as a cofactor in ulcerogenesis, H. pylori infection seems to be a predictive factor for ulcer recurrence [1]. Although H. pylori is known to alter gastric and duodenal morphology and function, the pathogenetic mechanisms behind the observed disturbances are only partly elucidated.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Borody T, Cole P, Noionan S, et al. (1988) Long-term Campylobacter pylori recurrence posteradication. Gastroenterology 94:43.

    Google Scholar 

  2. Hengels KJ, Heinrich G, Strohmeyer G (1986) Relationship between peptic cell mass, mucosal pepsinogen concentration, and pepsinogen secretion in normal gastric mucosa and gastritis. Gastroenterology 90:1457.

    Google Scholar 

  3. Samloff IM, Liebman WM (1974) Radioimmunoassay of group I pepsinogens in serum. Gastroenterology 66:494–502.

    PubMed  CAS  Google Scholar 

  4. Samloff IM (1982) Pepsinogen I and II. Purification from gastric mucosa and radioimmunoassay in serum. Gsstroenterology 82:26–33.

    CAS  Google Scholar 

  5. Samloff IM, Varis K, Ihamäki T, et al. (1982) Relationship among serum pepsinogen I, and II, and gastric mucosal histology. Gastroenterology 83:204–209.

    PubMed  CAS  Google Scholar 

  6. Samloff IM, Taggart RT, Hengels KJ (1985) Molecular variants of human aspartic proteinases. In: Kostka V (ed) Aspartic proteinases and their inhibitors. de Gruyter, Berlin, pp 79–85.

    Google Scholar 

  7. Samloff IM, Secrist DM, Passaro E (1975) A study of the relationship between serum group I pepsinogen levels and gastric acid secretion. Gastroenterology 69:1196–1200.

    PubMed  CAS  Google Scholar 

  8. Hirschowitz BI (1967) Secretion of pepsinogen. In: Code CF (ed) Handbook of Physiology. Alimentary Canal II. Williams and Wilkins, Baltimore, pp 889.

    Google Scholar 

  9. Hengels KJ, Halfkann M, Strohmeyer G (1988) Detection and control of spontaneous and drug-induced gastroduodenal lesions by determination of serum pepsinogens. Gastroenterology 94:183.

    Google Scholar 

  10. Gledhill H, Leischester RJ, Lightfoot N, et al. (1985) Epidemic hypochlorhydria. Br Med J 290:1383–1388.

    Article  CAS  Google Scholar 

  11. Ramsey EJ, Carey KV, Peterson WL, et al. (1979) Epidemic gastritis with hypochlorhydria. Gastroenterology 76:1449–1457.

    PubMed  CAS  Google Scholar 

  12. Graham DY, Alpert LC, Smith JL, et al. (1988) Iatrogenic Campylobacter pylori infection is a cause of epidemic achlorhydria. Am J Gastroenterol 83:974–980.

    PubMed  CAS  Google Scholar 

  13. Marshall BJ, Armstrong JA, McGechie DB et al. (1985) Attempt to fulfill Koch’s postulates for pyloric campylobacter. Med J Aust 142:436–439.

    PubMed  CAS  Google Scholar 

  14. Peterson W, Lee E, Skoglund M (1987) The role of campylobacter pyloridis in epidemic gastritis with hypochlorhydria. Gastroenterology 92:1575.

    Google Scholar 

  15. Brady CE, Hadfield TL, Hyatt JR, et al. (1988) Acid secretion and serum gastrin levels in individuals with campylobacter pylori. Gastroenterology 94:923–927.

    PubMed  Google Scholar 

  16. Spiro HM, Schwartz RD (1958) Superficial gastritis. A cause of temporary achlorhydria and hyperpepsinogenemia. N Eng J Med 259:682–684.

    Article  CAS  Google Scholar 

  17. Cave DR, Vargas M (1989) Effect of a campylobacter pylori protein on acid secretion by parietal cells. Lancet II:187–189.

    Article  Google Scholar 

  18. Wiersinga WM, Tytgat GN (1977) Clinical recovery owing to target parietal cell failure in a patient with Zollinger-Ellison syndrome. Gastroenterology 73:1413–1417.

    PubMed  CAS  Google Scholar 

  19. Goodwin CS, Armstrong JA, Marshall BJ (1986) Campylobacter pyloridis, gastritis, and peptic ulceration. J Clin Pathol 39:353–365.

    Article  PubMed  CAS  Google Scholar 

  20. Walsh JH, Richardson CT, Fordtran JS (1975) pH dependence of acid secretion and gastrin release in normal and ulcer subjects. J Clin Invest 55:462–468.

    Article  PubMed  CAS  Google Scholar 

  21. Levi S, Beardshall K, Haddad G et al. (1989) Campylobacter pylori and duodenal ulcers: the gastrin link. Lancet I:1167–1168.

    Article  Google Scholar 

  22. McColl KEL, Fullarton GM, El Nujumi AM et al. (1989) Lowered gastrin and gastric acidity after eradication of campylobacter pylori in duodenal ulcer. Lancet II:499–500.

    Article  Google Scholar 

  23. Odera G, Vaira G, Holton J et al. (1989) Amoxycillin plus tinidazole for campylobacter pylori gastritis in children: assessment by serum IgG antibody, pepsinogen I, and gastrin levels. Lancet II:690–692.

    Article  Google Scholar 

  24. Staub P, Jost R, Eberle Ch et al. (1989) Campylobacter pylori Besiedlung des Antrums: Einfluß auf Gastrin, Somatostatin, pankreatisches Polypeptid und Neurotensin. Schweiz Med Wochenschr 119:765–767.

    PubMed  CAS  Google Scholar 

  25. Wagner S, Freise J, Bucholz S et al. (1989) Campylobacter pylori and gastric acidity. Am J Gastroenterol 84:201–202.

    PubMed  CAS  Google Scholar 

  26. Samloff IM, Liebman WM, Panitch NM (1975) Serum group I pepsinogens by radioimmunoassay in control subjects and patients with peptic ulcer. Gastroenterology 69:83–90.

    PubMed  CAS  Google Scholar 

  27. Odera G, Vaira D, Holton J (1989) Serum pepsinogen I and IgG antibody to campylobacter pylori in non-specific abdominal pain in childhood. Gut 30:912–916.

    Article  Google Scholar 

  28. Langenberg ML, Tytgat GNJ, Shipper MEI, et al. (1984) Campylobacter-like organisms in the stomach of patients and healthy individuals. Lancet I:1348.

    Article  Google Scholar 

  29. Siurala M, Sipponen P, Kekki M (1988) Campylobacter pylori in a sample of Finnish population: relations to morphology and function of the gastric mucosa. Gut 29:909–915.

    Article  PubMed  CAS  Google Scholar 

  30. Flejou JF, Bahame P, Smith AC (1989) Pernicious anemia and campylobacter like organisms; is the gastric antrum resistant to colonisation? Gut 30:60–64.

    Article  PubMed  CAS  Google Scholar 

  31. Charasz N, Roucayrol AM, Chaplain C et al. (1989) Campylobacter pylori, pernicious and non pernicious anemia, achlorhydric atrophic gastritis and atrophic gastritis without achlorhydria. In: Megraud F, Lamouliatte H (eds) Gastroduodenal pathology and campylobacter pylori. Excerpta Medica, Amsterdam, pp 529–531.

    Google Scholar 

  32. Mainguet P, Delmee M, Debougmie JC (1989) Omeprazole, campylobacter pylori and duodenal ulcer. Lancet II:389–390.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Gastroenterology, Heinrich-Heine University, Moorenstr. 5, 4000, Düsseldorf, Germany

    K. J. Hengels

Authors
  1. K. J. Hengels
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Internal Medicine II, Robert-Koch-Straße 8, D-7900, Ulm, W-Germany

    P. Malfertheiner M.D., Priv.-Doz.  & H. Ditschuneit M.D., Prof.  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Hengels, K.J. (1990). Relationship Between Helicobacter pylori and Gastroduodenal Physiology: Acid Secretion and Pepsinogens. In: Malfertheiner, P., Ditschuneit, H. (eds) Helicobacter pylori, Gastritis and Peptic Ulcer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75315-2_45

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-75315-2_45

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75317-6

  • Online ISBN: 978-3-642-75315-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation