Gastric Metaplasia in Duodenal Mucosa — Key Factor for H. pylori Colonization and Duodenal Ulcer Pathogenesis?

  • P. Malfertheiner
  • A. Stanescu
  • G. Bode
  • K. Baczako
  • Ph. Kühl
  • H. Ditschuneit


Surface mucus cells (SMCs) of the gastric epithelium are the target cells for H. pylori colonization [1]. In contrast epithelial cells with absorptive function lining the duodenal and intestinal mucosa were never found to be colonized by H. pylori. The specific interrelationship (i.e. adhesion) between H. pylori and its gastric target cell is responsible for the unique location of H. pylori in the stomach (antrum and body area) with the only exception of its ectopic localization on metaplastic gastric SMCs in different parts of the gastrointestinal tract. Outside of the stomach H. pylori has been detected on gastric type epithelium in the duodenum [2–4], in the esophagus [5], Meckel’s diverticula [6] and the rectum [7].


Duodenal Ulcer Duodenal Mucosa Duodenal Bulb Gastric Epithelium Antral Mucosa 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • P. Malfertheiner
    • 1
  • A. Stanescu
    • 1
  • G. Bode
    • 1
  • K. Baczako
    • 1
  • Ph. Kühl
    • 1
  • H. Ditschuneit
    • 1
  1. 1.Abteilung Innere Medizin IIUniversität UlmUlmGermany

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