The Structure of Helicobacter pylori Urease

  • P. R. Hawtin
  • A. R. Stacey
  • D. G. Newell

Abstract

The urease is a prominent differential characteristic of Helicobacter pylori which is employed in diagnostic tests such as the C13/C14 breath test, serodiagnosis and the rapid CLO tests. The role of the enzyme is, as yet, unclear. The number of different ureolytic bacteria being found on the gastric mucosa of various hosts is increasing, raising the question of whether the ureases of these organisms are related.

Keywords

Electrophoresis Polypeptide Polyacrylamide Myeloma Dodecyl 

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References

  1. 1.
    Newell DG (1987) Identification of the outer membrane proteins of Campylobacter pyloridis and antigenic cross-reactivity between C. pyloridis and C. jejuni. J Gen Microbiol 133:163–170.PubMedGoogle Scholar
  2. 2.
    Newell DG, Lee A, Hawtin PR, Hudson MJ, Stacey AR and Fox J (1989) Antigenic conservation of the ureases of spiral — and helical — shaped bacteria colonising the stomachs of man and animals. 65:183–186.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • P. R. Hawtin
    • 1
    • 2
  • A. R. Stacey
    • 1
    • 2
  • D. G. Newell
    • 1
    • 2
  1. 1.PHLS, Level B, South Academic BlockSouthampton General HospitalSouthamptonUK
  2. 2.Division of PathologyPHLS CAMRSalisburyUK

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