The Acute Effect of Nimodipine on Intracranial Pressure and Cerebral Blood Flow
In acute stroke it has been shown that the calcium antagonist PY 108-068 induces a slight increase in mean cerebral blood flow (CBF) in some cases with a concomitant flow reduction in focal ischemic areas . In experimental studies in rat, nimodipine increases the CBF and impairs the autoregulation [3,5]. Different calcium antagonists might, however, have different effects on the CBF. Whether the increase in CBF exerts any adverse effect on intracranial pressure (ICP) has not been studied. In the present study we have investigated this using nimodipine.
KeywordsSingle Photon Emission Computerize Tomography Cerebral Blood Flow Intracranial Pressure Calcium Antagonist Perfusion Pressure
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