The Acute Effect of Nimodipine on Intracranial Pressure and Cerebral Blood Flow
In acute stroke it has been shown that the calcium antagonist PY 108-068 induces a slight increase in mean cerebral blood flow (CBF) in some cases with a concomitant flow reduction in focal ischemic areas . In experimental studies in rat, nimodipine increases the CBF and impairs the autoregulation [3,5]. Different calcium antagonists might, however, have different effects on the CBF. Whether the increase in CBF exerts any adverse effect on intracranial pressure (ICP) has not been studied. In the present study we have investigated this using nimodipine.
KeywordsCatheter Hydrocephalus Xenon Nimodipine
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- 3.Gaab MR, Hollerhage HG, Zumkeller M, Trost HA (1987) The effect of the Ca- antagonist nimodipine on cerebral blood flow autoregulation. J Cereb Blood Flow Metab 7 [Suppl 1]:170Google Scholar
- 4.Guggiari M, Guillaume A, Dagreou F, Philippon J, Viars P (1983) Intracranial pressure and hemodynamic effects of a new calcium channel blocking agent: nimodipine. Anesthesiology 59:A357Google Scholar
- 5.van der Kerckhoff W, Kazda S (1987) The autoregulation of cerebral blood flow is influenced by calcium antagonists. J Cereb Blood Flow Metab [Suppl 1]:169Google Scholar