The Acute Effect of Nimodipine on Intracranial Pressure and Cerebral Blood Flow

  • J. F. Schmidt
  • G. Waldemar
  • M. Albeck
  • O. B. Paulson
  • F. Gjerris
Conference paper
Part of the Advances in Neurosurgery book series (NEURO, volume 18)


In acute stroke it has been shown that the calcium antagonist PY 108-068 induces a slight increase in mean cerebral blood flow (CBF) in some cases with a concomitant flow reduction in focal ischemic areas [8]. In experimental studies in rat, nimodipine increases the CBF and impairs the autoregulation [3,5]. Different calcium antagonists might, however, have different effects on the CBF. Whether the increase in CBF exerts any adverse effect on intracranial pressure (ICP) has not been studied. In the present study we have investigated this using nimodipine.


Single Photon Emission Computerize Tomography Cerebral Blood Flow Intracranial Pressure Calcium Antagonist Perfusion Pressure 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • J. F. Schmidt
  • G. Waldemar
  • M. Albeck
  • O. B. Paulson
  • F. Gjerris
    • 1
  1. 1.Department of AnesthesiologyRigshospitaletCopenhagen ØDenmark

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