Effect of Nimodipine on the Outcome Following Operation for Ruptured Intracranial Aneurysms
The outcome of patients treated surgically for ruptured intracranial aneurysms is influenced by the severity of the initial subarachnoid hemorrhage (SAH) [4,10], the onset of delayed ischemic deterioration (DID) [9,11], and rebleeding . Several studies have suggested a protective anti-ischemic effect of nimodipine for DID [2,3,5–7]. Therefore we have changed our regime of operative management to early surgery combined with intravenous nimodipine medication. Retrospectively we have reviewed the outcome of our patients treated with and without nimodipine.
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- 8.Seiler RW, Reulen HJ, Huber P, Grolimund P, Ebeling U, Steiger HJ (1988) Outcome of aneurysmal subarachnoid hemorrhage in a hospital population: a prospective study including early operation, intravenous nimodipine, and transcranial Doppler ultrasound. Neurosurgery 23:598–604PubMedCrossRefGoogle Scholar