Abstract
In order to reveal interactions between the calcium antagonist nimodipine and the drugs used in anesthesia during neurosurgical procedures, we have performed hemodynamic, respiratory, metabolic, and endocrine investigations to address the following questions:
-
1.
What is the role of nimodipine as well as alcohol, the solvent of its preparation, in achieving intraoperative hypotension in normo- and hypertensive patients?
-
2.
Where is the site of action of nimodipine in producing hemodynamic alterations, and are there differences from other vasodilative drugs, such as nitroglyc-erin?
-
3.
Apart from its vasoactive properties, does nimodipine also influence pulmonary circulation, gas exchange, metabolism, and endocrine responses?
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Müller H, Kafurke H, Marek P, Zierski J, Hempelmann G (1988) Interactions between nimodipine and general anaesthesia — clinical investigations in 124 patients during neurosurgical operations. Acta Neurochir (Wien) [Suppl] 45:29–35
Müller H, Marek P, Otto O, Gips H, Börner U, Hempelmann G (1986) Intraoperative Anwendung von Nimodipin bei Operation von zerebralen Aneurysmen. In: Kazner E (ed) Nimotop in der Prophylaxe and Therapie neurologischer Ausfälle durch zerebrale Ischämie. G. Braun, Karlsruhe, pp 35–47
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Müller, H., Zierski, J. (1990). Interactions Between Nimodipine and Anesthetics Used in Neurosurgical Procedures. In: Bushe, KA., Brock, M., Klinger, M. (eds) Stabilizing Craniocervical Operations Calcium Antagonists in SAH Current Legal Issues. Advances in Neurosurgery, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75283-4_32
Download citation
DOI: https://doi.org/10.1007/978-3-642-75283-4_32
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-51967-6
Online ISBN: 978-3-642-75283-4
eBook Packages: Springer Book Archive