Skip to main content

Is High Dose Nimodipine Therapy Necessary Following Subarachnoid Hemorrhage? A Retrospective Study of 80 Patients with Aneurysmal Subarachnoid Hemorrhage over the Past 2 Years

  • Conference paper
  • 107 Accesses

Part of the book series: Advances in Neurosurgery ((NEURO,volume 18))

Abstract

The protective role of the calcium channel blocker nimodipine has been verified by a considerable number of open or double-blind studies over the past few years. In general a dose of 2mg/h i.v. or 240mg/day p.o has been used. Here we present a retrospective analysis of our treatment results with varying intravenous nimodipine dosages during the past 2 years.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Allen GS, Ahn HS, Preziosi TJ et al. (1983) Cerebral arterial spasm — a controlled trial of nimodipine in patients with subarachnoid hemorrhage. N Engl J Med 308:619–624

    Article  PubMed  CAS  Google Scholar 

  2. Auer LM (1984) Acute operation and preventive nimodipine improve outcome in patients with ruptured cerebral aneurysms. Neurosurgery 15:57–66

    Article  PubMed  CAS  Google Scholar 

  3. Gilsbach JM, Härders AG, Eggert HR et al. (1988) Early aneurysm surgery: a 7 year clinical practice report. Acta Neurochir (Wien) 90:91–102

    Article  CAS  Google Scholar 

  4. Grotenhuis JA, Bettag W (1986) Prevention of symptomatic vasospasm after SAH by constant venous infusion of nimodipine. Neurol Res 8:243–249

    PubMed  CAS  Google Scholar 

  5. Härders A (1986) Neurosurgical applications of transcranial Doppler sonography. Springer, Vienna New York

    Google Scholar 

  6. Jan M, Bucheit F, Tremoulet M (1988) Therapeutic trial of intravenous nimodipine in patients with established cerebral vasospasm after rupture of intracranial aneurysms. Neurosurgery 23:154–157

    Article  PubMed  CAS  Google Scholar 

  7. Kazner E, Sprung C, Adelt D et al. (1985) Clinical experience with nimodipine in the prophylaxis of neurological deficits after subarachnoid hemorrhage. Neurochirurgia 28:114–117

    Google Scholar 

  8. Ljunggren B, Brandt L, Saeveland H et al. (1984) Outcome in 60 consecutive patients treated with early aneurysm operation and intravenous nimodipine. J Neurosurg 61:864–873

    Article  PubMed  CAS  Google Scholar 

  9. Mee E, Dorrance D, Lowe D et al. (1988) Controlled study of nimodipine in aneurysm patients treated early after subarachnoid hemorrhage. Neurosurgery 22:484–491

    Article  PubMed  CAS  Google Scholar 

  10. Philippon J, Grob R, Dagreou F et al. (1986) Prevention of vasospasm in subarachnoid hemorrhage. A controlled study with nimodipine. Acta Neurochir (Wien) 82:110–114

    Google Scholar 

  11. Seiler RW, Grolimund P, Zurbruegg HR (1987) Evaluation of the calcium-antagonist nimodipine for the prevention of vasospasm after subarachnoidal hemorrhage. Acta Neurochir (Wien) 85:7–16

    Article  CAS  Google Scholar 

  12. Seiler RW, Reulen HJ, Huber P et al. (1988) Outcome of aneurysmal subarachnoid hemorrhage in a hospital population: a prospective study including early operation, intravenous nimodipine, and transcranial Doppler ultrasound. Neurosurgery 23:598–604

    Article  PubMed  CAS  Google Scholar 

  13. Stolke D, Seifert V (1988) Früh- oder Spätoperation des rupturierten Aneurysmas? Eine Analyse anhand von 356 Fällen. Neurochirurgia 31:81–87

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Birn, G., Stallmach, M. (1990). Is High Dose Nimodipine Therapy Necessary Following Subarachnoid Hemorrhage? A Retrospective Study of 80 Patients with Aneurysmal Subarachnoid Hemorrhage over the Past 2 Years. In: Bushe, KA., Brock, M., Klinger, M. (eds) Stabilizing Craniocervical Operations Calcium Antagonists in SAH Current Legal Issues. Advances in Neurosurgery, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75283-4_31

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-75283-4_31

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-51967-6

  • Online ISBN: 978-3-642-75283-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics