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Using Synthetic Peptide Reagents to Distinguish Infections Caused by Different HIV Strains

  • Conference paper
Retrovirus Infections of the Nervous System

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 160))

Abstract

As the nucleic acid sequences of additional isolates of human immunodeficiency virus (HIV) have been determined, the remarkable heterogeneity within this group of viruses has become apparent. HIV has been subclassified into HIV type 1, the retrovirus first shown to cause the acquired immunodeficiency syndrome (AIDS), and HIV type 2, a more recently discovered retrovirus prevalent in West Africa. HIV-1 and HIV-2 have identical amino acids at about 59% of positions in the relatively conserved core proteins and at about 42% of positions in the envelope proteins (Guyader et al. 1987). There is partial antigenic cross-reactivity between the core proteins of the two viruses, but cross-reactivity between envelope proteins has not been described (Clavel et al. 1986, 1987; Brun-Vezinet et al. 1987). Consequently, an enzyme-linked immunosorbent assay (ELISA) containing HIV-1 whole-virus lysate as an antigen detects some HIV-2-positive sera, but is an inconsistent and unreliable test for HIV-2 diagnosis.

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Authors and Affiliations

  1. Department of Immunology, Scripps Clinic and Research Foundation, 10666 N. Torrey Pines Road, La Jolla, CA, 92037, USA

    J. W. Gnann Jr. & M. B. A. Oldstone

Authors
  1. J. W. Gnann Jr.
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  2. M. B. A. Oldstone
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Editors and Affiliations

  1. Dept. of Neuropharmacology, Scripps Clinic and Research Foundation, 10666 N. Torrey Pines Road, 92037, La Jolla, CA, USA

    Michael B. A. Oldstone M.D.

  2. The Wistar Institute, 36th Street at Spruce, 19104, Philadelphia, PA, USA

    Hilary Koprowski M.D. (Direktor) (Direktor)

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© 1990 Springer-Verlag Berlin · Heidelberg

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Gnann, J.W., Oldstone, M.B.A. (1990). Using Synthetic Peptide Reagents to Distinguish Infections Caused by Different HIV Strains. In: Oldstone, M.B.A., Koprowski, H. (eds) Retrovirus Infections of the Nervous System. Current Topics in Microbiology and Immunology, vol 160. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75267-4_8

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  • DOI: https://doi.org/10.1007/978-3-642-75267-4_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75269-8

  • Online ISBN: 978-3-642-75267-4

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