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Human Immunodeficiency Virus: Infection of the Nervous System

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Book cover Retrovirus Infections of the Nervous System

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 160))

Abstract

Patients with acquired immune deficiency syndrome (AIDS) suffer from a variety of neurologic disorders (Levy et al. 1985). Between 10% and 25% of AIDS or AIDS-related complex (ARC) patients present with neurologic symptoms (Anders et al. 1986; Navia et al. 1986a). In the terminal phases of AIDS, up to one-half of all patients develop an encephalopathy, with autopsy studies demonstrating as much as 80% with CNS pathology (Levy et al. 1985; Anders et al. 1986). Even individuals who show only serologic evidence of human immunodeficiency virus (HIV) infection, who are otherwise clinically normal, develop neurologic illness (Mirra et al. 1986; Lenhardt et al. 1988). We will briefly review the peripheral neuromuscular and central encephalopathic illnesses associated with HIV infection and our understanding of the pathogenesis of these diseases.

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Authors and Affiliations

  1. Department of Pathology (Neuropathology), University of California, San Diego, La Jolla, California, 92093, USA

    C. A. Wiley

  2. Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, California, 92037, USA

    J. A. Nelson

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  1. C. A. Wiley
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Editors and Affiliations

  1. Dept. of Neuropharmacology, Scripps Clinic and Research Foundation, 10666 N. Torrey Pines Road, 92037, La Jolla, CA, USA

    Michael B. A. Oldstone M.D.

  2. The Wistar Institute, 36th Street at Spruce, 19104, Philadelphia, PA, USA

    Hilary Koprowski M.D. (Direktor) (Direktor)

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© 1990 Springer-Verlag Berlin · Heidelberg

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Wiley, C.A., Nelson, J.A. (1990). Human Immunodeficiency Virus: Infection of the Nervous System. In: Oldstone, M.B.A., Koprowski, H. (eds) Retrovirus Infections of the Nervous System. Current Topics in Microbiology and Immunology, vol 160. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75267-4_10

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  • DOI: https://doi.org/10.1007/978-3-642-75267-4_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75269-8

  • Online ISBN: 978-3-642-75267-4

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