Human Immunodeficiency Virus: Infection of the Nervous System

  • C. A. Wiley
  • J. A. Nelson
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 160)


Patients with acquired immune deficiency syndrome (AIDS) suffer from a variety of neurologic disorders (Levy et al. 1985). Between 10% and 25% of AIDS or AIDS-related complex (ARC) patients present with neurologic symptoms (Anders et al. 1986; Navia et al. 1986a). In the terminal phases of AIDS, up to one-half of all patients develop an encephalopathy, with autopsy studies demonstrating as much as 80% with CNS pathology (Levy et al. 1985; Anders et al. 1986). Even individuals who show only serologic evidence of human immunodeficiency virus (HIV) infection, who are otherwise clinically normal, develop neurologic illness (Mirra et al. 1986; Lenhardt et al. 1988). We will briefly review the peripheral neuromuscular and central encephalopathic illnesses associated with HIV infection and our understanding of the pathogenesis of these diseases.


Human Immunodeficiency Virus Acquire Immune Deficiency Syndrome Multinucleated Giant Cell Acquire Immune Deficiency Syndrome Patient Human Immunodeficiency Virus Encephalitis 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1990

Authors and Affiliations

  • C. A. Wiley
    • 1
  • J. A. Nelson
    • 2
  1. 1.Department of Pathology (Neuropathology)University of CaliforniaSan Diego, La JollaUSA
  2. 2.Department of ImmunologyScripps Clinic and Research FoundationLa JollaUSA

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