Advertisement

State of the Art: Pancreatic Transplantation

  • J. S. Najarian
  • D. E. R. Sutherland
Conference paper

Abstract

Pancreas transplants have been performed at the University of Minnesota since 1966 [1]. The results of the first series of 14 transplants, ending in 1973, have been reported in detail [2, 3]. In 1978 pancreas transplants were resumed at the University of Minnesota [4], first in diabetic patients who already had kidney transplants, then in nonuremic non-kidney transplant patients [5–7], and finally in uremic or preuremic recipients of simultaneous kidney transplants [8]. The grafts have been procured from living related and cadaver donors [9]. We have tested a variety of surgical techniques [6, 10] and immunosuppressive regimens [6, 8]. This paper summarizes our overall, initial, and most recent results according to multiple variables.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Kelley WD, Lillehei RC, Merkel FK et al. (1987) Allotransplantation of the pancreas and duodenum along with the kidney in diabetic nephropathy. Surgery 61: 827Google Scholar
  2. 2.
    Lillehei RC, Simmons RL, Najarian JS et al. (1970) Pancreaticoduodenal allotransplantation: experimental and clinical experience. Ann Surg 172: 405–436PubMedCrossRefGoogle Scholar
  3. 3.
    Lillehei RC, Ruiz JO, Acquino C et al. (1976) Transplantation of the pancreas. Acta Ebdicrebik 83 [Suppl 205]: 303Google Scholar
  4. 4.
    Sutherland DER, Goetz FC, Najarian JS (1979) Intraperitoneal transplantation of immediately vascularized segmental pancreatic grafts without duct ligation: a clinical trial. Transplantation 28: 485–491PubMedGoogle Scholar
  5. 5.
    Sutherland DER, Goetz FC, Elick BA, Najarian JS (1982) Experience with 49 segmental pancreas transplants in 45 diabetic patients. Transplantation 34: 330–338PubMedCrossRefGoogle Scholar
  6. 6.
    Sutherland DER, Goetz FC, Najarian JS (1984) One hundred pancreas transplants at a single institution. Ann Surg 200: 414–440PubMedCrossRefGoogle Scholar
  7. 7.
    Sutherland DER, Kendall DM, Moudry KC, Navarro X, Kennedy WR, Ramsay RC, Steffes MW, Mauer SM, Goetz FC, Dunn DL, Najarian JS (1988) Pancreas transplantation in nonuremic, type I diabetic recipients. Surgery 102: 453–464Google Scholar
  8. 8.
    Sutherland DER, Goetz FC, Moudry KC, Najarian JS (1988) Pancreatic transplantation — a single institution’s experience. Diabetes, nutrition and metabolism 1: 57–64Google Scholar
  9. 9.
    Sutherland DER, Goetz FC, Najarian JS (1984) Pancreas transplants from related donors. Transplantation 38: 625–633PubMedCrossRefGoogle Scholar
  10. 10.
    Prieto M, Sutherland DER, Goetz FC, Rosenberg ME, Najarian JS (1987) Pancreas transplant results according to technique of duct management: bladder versus enteric drainage. Surgery 102: 680–691PubMedGoogle Scholar
  11. 11.
    Ramsay RC, Goetz FC, Sutherland DER, Mauer SM, Robinson LL, Cantrill HL, Knobloch WH, Najarian JS (1988) Progression of diabetic retinopathy after pancreas transplantation for insulin-dependent diabetes mellitus. N Engl J Med 318: 208–214PubMedCrossRefGoogle Scholar
  12. 12.
    van der Vliet JA, Navarro X, Kennedy WR, Goetz FC, Najarian JS, Sutherland DER (1988) The effect of pancreas transplantation on diabetic polyneuropathy. Transplantation 45: 368–370PubMedCrossRefGoogle Scholar
  13. 13.
    Bilous RW, Mauer SM, Sutherland DER et al. (1987) Glomerular structure and function following successful pancreas transplantation for insulin independent diabetes mellitus. Diabetes 36: 43 ACrossRefGoogle Scholar
  14. 14.
    DeFrancisco AM, Mauer SM, Steffes MW, Goetz FC, Najarian JS, Sutherland DER (1987) The effect of cyclosporine on native renal function in nonuremic diabetic recipients of pancreas transplants. J Diab Compl 1: 128–131Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • J. S. Najarian
    • 1
  • D. E. R. Sutherland
    • 1
  1. 1.Department of SurgeryUniversity of Minnesota HospitalMinneapolisUSA

Personalised recommendations