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Lariat Ethers in Membranes and as Membranes

  • George W. Gokel
  • Luis Echegoyen
Part of the Bioorganic Chemistry Frontiers book series (BIOORGANIC, volume 1)

Abstract

Lariat ethers are macrocyclic (crown ethers) that have one or more sidearms appended to the ring. The sidearms usually contain Lewis basic donor groups when cation binding properties are desired. By combining both a macroring and a sidearm, the advantages of both three-dimensional encapsulation and flexibility are realized. Flexibility is important because cation transport requires rapid complexation and release, especially the latter if it is to be effective. The structural, cation binding, and transport properties are discussed herein. It is also possible to prepare macrocycles having lipophilic sidearms that do not contain any donor group. If lipophilic is enough, these lariat ethers self-assemble into micelles, niosomes, or vesicles. If appropriately designed, these compounds may assemble into smaller, more readily characterized structures. Examples of all of these cases are illustrated herein.

Keywords

Cloud Point Crown Ether Critical Micelle Concentration Phase Transfer Catalysis Cation Binding 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • George W. Gokel
    • 1
  • Luis Echegoyen
    • 1
  1. 1.Department of ChemistryUniversity of MiamiCoral GablesUSA

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