Suppressor T-Cell Memory

  • S. Adelstein
  • H. Pritchard-Briscoe
  • R. H. Loblay
  • A. Basten
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 159)


The immune response of the host to its environment necessitates a finely tuned network of feedback mechanisms designed to provide for an effective humoral and cellular response to potential pathogens without damage to self tissues. Therefore the maintenance of the immunological milieu interieur depends not only on counterbalances to regulate the extent of protective immune responses to foreign antigens but also on a series of controls to limit potential self-reactivity. Among the cybernetic mechanisms thought to be responsible for immuno regulation are antigen itself, antibody-mediated feedback, T-cell-dependent suppression and idiotypic networks (Basten et al. 1980; Nossal 1983).


Major Histocompatibility Complex Spleen Cell Suppressor Cell Idiotypic Network Primary Suppression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Basten A, Miller JFAP, Johnson P (1975) T cell-dependent suppression of an anti-hapten antibody response. Transplant Rev 26: 130–169PubMedGoogle Scholar
  2. Basten A, Miller JFAP, Loblay R, Johnson P, Gamble J, Chia E, Pritchard-Briscoe H, Callard R, McKenzie IFC (1978) T cell-dependent suppression of antibody production I. Characteristics of suppressor T cells following tolerance induction. Eur J Immunol 8: 360–370PubMedCrossRefGoogle Scholar
  3. Basten A, Loblay RH, Trent RJ, Gatenby PA (1980) Suppressor T cells in immune homeostasis. In: Thompson RA (ed) Recent advances in clinical immunology, vol 2. Churchill Livingstone Edinburgh, pp 33–63Google Scholar
  4. Basten A, Gibson J, Loblay RH, Wong KL, Fazekas De St. Groth B (1985) The role of memory suppressor T cells in self tolerance: induction in utero and in athymic mice. Adv Exp Med Biol 186:511–520PubMedGoogle Scholar
  5. Benjamin DC (1975) Evidence for specific suppression in the maintenance of immunologic tolerance. J Exp Med 141:635–646PubMedCrossRefGoogle Scholar
  6. Callard RE, Fazekas de St. Groth B, Basten A, McKenzie IFC (1980) Immune function in aged mice V. Role of suppressor cells. J Immunol 124: 52–58PubMedGoogle Scholar
  7. Cox KO, Howles A (1981) Induction and regulation of autoimmune haemolytic anaemia in a mouse model. Immunol Rev 55: 394–401CrossRefGoogle Scholar
  8. Doyle MV, Parks DE, Weigle WO (1976) Specific transient suppression of the immune response by HGG tolerant spleen cells II. Effector cells and target cells. J Immunol 117: 1152–1158PubMedGoogle Scholar
  9. Eardley DD, Sercarz EE (1977) Recall of specific suppression: co-dominance of suppression after primary or secondary antigen stimulation. J Immunol 118: 1306–1310PubMedGoogle Scholar
  10. Etlinger HM, Chiller JM (1977) Induction of tolerance in athymic mice with an antigen which is highly immunogenic in euthymie mice. Cell Immunol 33: 297–308PubMedCrossRefGoogle Scholar
  11. Fazekas de St. Groth B, Basten A, Loblay RH (1984) Induction of memory and effector suppressor T cells by perinatal exposure to antigen. Eur J Immunol 14: 228–235CrossRefGoogle Scholar
  12. Flood PM (1985) The role of suppressor cells in maintaining tolerance to self molecules-a commentary. J Mol Cell Immunol 2: 140–142PubMedGoogle Scholar
  13. Gibson J, Basten A, Walker KZ, Loblay RH (1985) A role for suppressor T cells in induction of selftolerance. Proc Natl Acad Sci USA 82: 5150–5154PubMedCrossRefGoogle Scholar
  14. Gibson J (1986) Mechanisms of self tolerance. PhD thesis, University of SydneyGoogle Scholar
  15. Gibson J, Basten A (1988) In vivo properties of murine autoreactive T cell clones with specificity for erythrocytes. Autoimmunity 2, 21–29PubMedCrossRefGoogle Scholar
  16. Green DR, Flood PM and Gershon RK (1983) Immunoregulatory T-cell pathways. Annu Rev Immunol 1:439–463PubMedCrossRefGoogle Scholar
  17. Heuer J, Bruner K, Opalka B, Kölsch E (1982) A cloned T-cell line from a tolerant mouse represents a novel antigen-specific suppressor cell type. Nature 296: 456–459PubMedCrossRefGoogle Scholar
  18. Hodes RJ (1985) Cloned Lyt-1+, 2- T suppressor cells-a commentary. J Mol Cell Immunol 2: 14–16PubMedGoogle Scholar
  19. Janeway CA (1988) Frontiers of the immune system. Nature 333: 804–806PubMedCrossRefGoogle Scholar
  20. Janeway CA, Jones B, Hayday A (1988) Specificity and function of T cells bearing γδ receptors. Immunol Today 9:3: 73–76PubMedCrossRefGoogle Scholar
  21. Kanellopoulos-Langevin C, Mathieson BJ, Perkins A, Maynard A, Asofsky R (1984) Regulation of anti-hapten responses in vivo: memory, carrier-specific Lyt-2+ T cells can terminate antibody production without altering the peak of response. J Immunol 132:4: 1639–1646PubMedGoogle Scholar
  22. Klein J (1986) Natural History of the Major Histocompatibility Complex. Wiley, New YorkGoogle Scholar
  23. Kronenberg M, Steinmetz M, Kobon J, Kraig E, Kapp JA, Pierce CW, Sorensen CM, Suzuki G, Tada T, Hood L (1983) RNA transcript for I-J polypeptides are apparently not encoded between I-A and I-E subregions of the murine major histocompatibility complex. Proc Natl Acad Sci USA 80: 5704–5708PubMedCrossRefGoogle Scholar
  24. Loblay RH, Basten A (1986) Why is the immune system not overwhelmed by suppression? A reductionist paradox. In: Hoffman GW, Levy JG, Nepom GT (eds) Paradoxes in immunology. CRC Press, Boca Raton, FL, pp 115–120Google Scholar
  25. Loblay RH, Pritchard-Briscoe H, Basten A (1978) Suppressor T cell memory. Nature 272: 620–622PubMedCrossRefGoogle Scholar
  26. Loblay RH, Fazekas de St. Groth B, Pritchard-Briscoe H, Basten A (1983) Suppressor T cell memory II: the role of memory suppressor T cells in tolerance to human gammaglobulin. J Exp Med 157:957–973PubMedCrossRefGoogle Scholar
  27. Loblay RH, Pritchard-Briscoe H, Basten A (1984) Suppressor T cell memory: induction and recall of HGG-specific memory suppressor T cells and their role in regulation of antibody production. Aust J Exp Biol Med Sci 62: 11–25PubMedCrossRefGoogle Scholar
  28. Matis LA, Cron R, Bluestone JA (1987) Major histocompatibility complex-linked specificity of γδ receptor bearing T lymphocytes. Nature 330: 262–64PubMedCrossRefGoogle Scholar
  29. Miller JFAP, Sprent J (1971) Cell-to-cell interaction in the immune response VI. Contribution of thymus-derived cells and antibody-forming cell precursors to immunological memory. J Exp Med 134: 66–82PubMedCrossRefGoogle Scholar
  30. Möller G (1988) Do suppressor T cells exist? Scand J Immunol 27: 247–250 (editorial)PubMedCrossRefGoogle Scholar
  31. Nossal GJV (1983) Cellular mechanisms of immunologic tolerance. Annu Rev Immunol 1: 33–62PubMedCrossRefGoogle Scholar
  32. Parks DE, Shaller DA, Weigle WO (1979) Induction and mode of action of suppressor cells generated against human gammaglobulin II. Effects of colchicine. J Exp Med 149: 1168–1182PubMedCrossRefGoogle Scholar
  33. Pereira P, Larsson-Sciard EL, Coutinho A, Bandeira A (1988) Suppressor versus cytotoxic CD8+ T lymphocytes. Where are the artefacts? Scand J Immunol 27: 625–628PubMedCrossRefGoogle Scholar
  34. Playfair JHL, Marshall-Clarke S (1973) Induction of red cell auto-antibodies in normal mice. Nature (New Biology) 243: 213–214CrossRefGoogle Scholar
  35. Steinmetz M, Minard K, Horvath S, McNicholas J, Srelinger J, Wake C, Long E, Mach V, Hood L (1982) A molecular map of the immune response region from the major histocompatibility complex of the mouse. Nature 300: 35–42PubMedCrossRefGoogle Scholar
  36. Townsend ARM, Bastin J, Gould K, Brownlee GG (1986) Cytotoxic T lymphocytes recognize influenza haemagglutinin that lacks a signal sequence. Nature 324: 575–577PubMedCrossRefGoogle Scholar
  37. Walker KZ, Gibson J, Basten A (1987) Clonal analysis of autoreactive B cells in a murine model of autoimmune haemolytic anaemia. Cell Immunol 107: 227–237PubMedCrossRefGoogle Scholar
  38. Waters CA, Pilarski M, Wegman TG, Deiner E (1979) Tolerance induction during ontogeny I: presence of active suppression in mice rendered tolerant to human y-globulin in utero correlated with the breakdown of the tolerant state. J Exp Med 149: 1134–1151PubMedCrossRefGoogle Scholar
  39. Weigle WO (1973) Immunological unresponsiveness. Adv Immunol 16: 61–122PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • S. Adelstein
    • 1
  • H. Pritchard-Briscoe
    • 1
  • R. H. Loblay
    • 1
  • A. Basten
    • 1
  1. 1.Clinical Immunology Research CentreUniversity of SydneySydneyAustralia

Personalised recommendations