Subsets of Rat CD4+ T Cells Defined by Their Differential Expression of Variants of the CD45 Antigen: Developmental Relationships and In Vitro and In Vivo Functions
Thymus-derived lymphocytes have been shown to mediate a wide range of immunological functions both as direct effectors in cell-mediated immunity and as helper or inducer cells for B cells, macrophages, bone marrow cells and other T cells. In addition, the lymphokines that they produce have been shown to act not only on leucocytes but also on non-bone marrow derived cells. This wide range of T-cell functions has only recently been fully appreciated, but early work using alloantisera in mice established that T cells with different functional specializations could be distinguished phenotypically on the basis of whether or not they expressed what came to be called the CD8 antigen (Cantor and Boyse 1975).
KeywordsArthritis Tyrosine Electrophoresis Polypeptide Polyacrylamide
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