The Generation of B-Cell Memory: A Working Hypothesis
The process by which secondary B cells are generated has intrigued immunologists for several decades. This is particularly true since appropriate antigenic stimulation leads both to a selective increase in the frequency of B cells responsive to the immunizing antigen and to the generation of a population of cells (secondary B cells) that are phenotypically and functionally distinct from primary B cells specific for the same antigen.
KeywordsSomatic Mutation Secondary Response Somatic Hypermutation Variable Region Gene Unequal Division
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