Expansion, Selection and Maintenance of Memory B-Cell Clones
What do immunologists mean when they talk about memory? At the level of immune responses this is not too difficult to define as there are several properties of a secondary (or memory) response that differ from a primary response, i.e. the kinetics of a secondary response are accelerated, the isotype of antibody produced is different (relatively more IgG or IgA compared with IgM) and the affinity of the antibody produced is increased. However, at the cellular level definitions are many and varied. Current convention regards memory B cells as long-lived, resting cells (Hood et al. 1984) that have switched to isotypes downstream of µ and δ (Coffman and Cohn 1977; Black et al. 1980), although many still express these isotypes (Black et al. 1980; Yefenof et al. 1985; Zan-Bar et al. 1979) while carrying somatically mutated V genes (Berek et al. 1987; Siekevitz et al. 1987) and having different activation requirements (Yefenof et al. 1985, 1986; Pillai et al. 1984).
KeywordsMemory Cell Germinal Centre Follicular Dendritic Cell Soluble Antigen Germinal Centre Reaction
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