Abstract
The susceptibility towards the development of type 1 or insulin-dependent diabetes mellitus (IDDM) in humans is inherited in a complex and, as yet, unclear fashion. At least one genetic component is linked to the class II region of the major histocompatibility complex (MHC), but this component appears to be insufficient in determining susceptibility towards the disease. The identification of a gene or combination of genes which leads to the development of the disease has been hampered by the diverse genetic background of the human population, possible heterogeneity within the disease itself, and the low penetrance of the gene(s) involved.
Keywords
- Major Histocompatibility Complex
- Repetitive Sequence
- Brown Norway
- Major Histocompatibility Complex Haplotype
- Diabetes Gene
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Bender K, Adams M, Baverstock PR, den Bieman M, Bissbort S, Brdicka R, Butcher GW, Cramer DV, von Deimling O, Festing MFW, Gunther E, Guttmann RD, Hedrich HJ, Kendall PB, Kluge R, Moutier R, Simon B, Womack JE, Yamada J, van Zutphen B (1984) Biochemical markers in inbred strains of the rat (Rattus norvegicus). Immunogenetics 19: 257–266
Bjørck L, Kryspin-Sørensen I, Dyrberg T, Lernmark A, Kastern W (1986) A deletion in a rat major histocompatibility complex class I gene is linked to the absence of beta2-microglobulin-containing serum molecules. Proc Natl Acad Sci USA 83: 5630–5633
Botstein D, White RL, Skolnick M, Davis RW (1980) Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet 32: 314–331
Britten R, Davidson EH (1969) Gene regulation for higher cells A theory. Science 165: 349–357
Britten R, Davidson EH (1971) Repetitive and non-repetitive DNA sequences and a speculation on the origins of evolutionary novelty. Q Rev Biol 46: 111–137
Colle E, Guttmann RD, Seemayer T (1981) Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex. J Exp Med 154: 1237–1242
Colle E, Guttmann RD, Seemayer TA, Michel F (1983) Spontaneous diabetes mellitus syndrome in the rat. IV. Imunogenetic interactions of MHC and non-MHC components of the syndrome. Metabolism 32: 54–61
Colle E, Guttmann RD, Fuks A (1986) Insulin-Dependent diabetes mellitus is associated with genes that map to the right of the class IRT1. A locus of the major histocompatibility complex of the rat. Diabetes 35: 454–458
Collins FS, Weissman SM (1984) Directional cloning on DNA fragments at a large distance from an initial probe: circularization method. Proc Natl Acad Sci USA 81: 6812–6816
Davies KE (1981) The application of DNA recombinant technology to the analysis of the human genome and genetic disease. Hum Genet 58: 351–357
Deininger PL, Daniels GR (1986) The recent evolution of mammalian repetitive DNA elements. Trends Genet 2: 76–80
Gilliam TC, Tanzi RE, Haines JL, Bonner TI, Faryniarz AG, Hobbs AJ, MacDonald ME, Cheng SV, Folstein SE, Conneally PM, Wexler NS, Gusella JF (1987) Localization of the Huntington’s disease gene to a small segment of chromosome 4 flanked by D4S10 and the telomere. Cell 50: 565–571
Guberski DL, Butler L, Kastern W, Like A A (1989) Genetic studies in inbred BB/Wor rats: analysis of progeny produced by crossing lymphopenic diabetes prone with non-lymphopenic rats. Diabetes (in press)
Gusella JF, Wexler NS, Conneally PM, Naylor SL, Anderson MA, Tanzi RE, Watkins PC, Ottina K, Wallace MR, Sakaguchi AY, Young AB, Shoulson I, Bonilla M, Martin JB (1983) A polymorphic DNA marker genetically linked to Huntington’s disease. Nature 306: 234–239
Guttmann RD, Colle E, Michel F, Seemayer T (1983) Spontaneous diabetes mellitus syndrome in the rat. II. T lymphopenia and its association with clinical disease and pancreatic lymphocytic infiltration. J Immunol 130: 1732–1735
Hattori M, Buse JB, Jackson RA, Glimcher L, Dorf ME, Minami M, Makino S, Moriwaki K, Kuzuya H, Imura H, Strauss WM, Scidman JG, Eisenbarth G (1986) The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex. Science 231: 733–735
Herold KC, Kastern W, Markholst H, Lernmark A (1989) Derivation of non-lymphopenic BB rats with an intercross breeding. Autoimmunity (in press)
Hill AVS, Jeffreys AJ (1985) Use of minisatellite DNA probes for determination of twin zygosity at birth. Lancet 2: 1394–1395
Holowachuk EW, Greer MK (1989) Unaltered class II histocompatibility antigens and pathogenesis of IDDM in BB rats. Diabetes 38: 267–271
Jackson RA, Buse JB, Rifai R, Pelletier D, Milford EL, Carpenter CB, Eisenbarth GS, Williams RM (1984) Two genes required for diabetes in BB rats. Evidence from cyclical intercrosses and backcrosses. J Exp Med 159: 1629–1636
Jeffreys AJ, Wilson V, Thein SL (1985a) Hypervariable ‘minisatellite’ regions in human DNA. Nature 314: 67–73
Jeffreys AJ, Brookfield JFY, Semeonoff R (1985b) Positive identification of one immigration test-case using human DNA fingerprints. Nature 317: 818–819
Jeffreys AJ, Wilson V, Thein SL, Weatherall DJ, Ponder BAJ (1986) DNA “Fingerprints” and segregation analysis of multiple markers in human pedigrees. Am J Hum Genet 39: 11–24
Jelinek W, Schmid CW (1982) Repetitive sequences in eukaryotic DNA and their expression. Annu Rev Biochem 51:813–844
Knowlton RG, Cohen-Haguenauer O, Cong NV, Frezal J, Brown VA, Barker D, Braman JC, Schümm JW, Tsui LC, Buchwald M, Donis-Keller H (1985) A polymorphic DNA marker linked to cystic fibrosis is located in chromosome 7. Nature 318: 380–385
Kryspin-Sørensen I, Dyrberg T, Kastern W (1986) Genetic heterogeneity within the major histocompatibility complex of various BB rat sublines. Diabetologia 29: 307–312
Lang F, Kastern W (1989) The gene for the rat lymphocyte alloantigen is linked neither to diabetes nor lymphopenia and is apparently functional in the diabetic BB rat. Eur J Immunol (submitted)
Leiter E, Prochazka M (1988) Genetic loci controlling diabetes susceptibility in NOD mice. Diabetes Res. Clin Pract 5 [suppl J]: S188
Like A A, Guberski DL, Butler L (1986) Diabetic Bireeding/Worcestmr (BB/Wor) rats need not be lymphopenic. J Immunol 136: 3254–3258
Murray JM, Davies KE, Harper PS, Meredith L, Mueller CR, Williamson R (1982) Linkage relationship of a cloned DNA sequence on the short arm of the X chromosome to Duchenne muscular dystrophy. Nature 300: 69–71
O’Brien SJ (1987)Genetic maps-1987. Cold Spring Harbor Laboratory, New York
Ono SJ, Issa-Chergui B, Colle E, Guttmann RD, Seemayer TA, Fuks A (1988) Enhanced MHC class I heavy-chain gene expression in pancreatic islets. Diabetes 37: 1411–1418
Pearson WR, Wu JR, Bonner J (1978) Analysis of Rat Repetitive DNA sequences. Biochemistry 17:51–59
Poussier P, Nakhooda AF, Falk J, Lee C, Marliss EB (1982) Lymphopenia and abnormal lymphocyte subsets in the “BB” rat: relationship to the diabetic syndrome. Endocrinology 110: 1825–1827
Poustka A, Lehrach H (1986) Jumping libraries and linking libraries: the next generation of molecular tools in mammalian genetics. Trends Genet 2: 174–179
Prochazka M, Leiter EH, Serreze DV, Coleman DL (1987) Three recessive loci required for insulin-dependent diabetes in nonobese diabetic mice. Science 237: 286–289
Rouleau GA, Wertelecki W, Haines JL, Hobbs WJ, Trofatter JA, Scizinger BR, Martuza RL, Superneau DW, Conneally PM, Gusella JF (1987) Genetic linkage of bilateral acoustic neurofibromatosis to a DNA marker on chromosome 22. Nature 329: 246–248
Schmid CW, Jelinek W (1982) The Alu family of dispersed repetitive sequences. Science 216: 1065–1070
Stock W, Gunther E (1979) Serologic analysis of two new alloantigenic systems of the rat major histocompatibility complex. Transplant Proc 11 (3): 1579–1581
White RL (1984) Human genetics. Lancet 2: 1257–1262
Wonigeit K, Hedrich HJ, Gunther E (1979) Serologic and histogenic analysis of apparently identical RTI haplotypes. Transplant Proc 11 (3): 1584–1586
Wyman AR, White R (1980) A highly polymorphic locus in human DNA. Proc Natl Acad Sci USA 77: 6574–6578
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag Berlin · Heidelberg
About this paper
Cite this paper
Kastern, W., Lang, F., Kryspin-Sørensen, I. (1990). The Genetics of Insulin-Dependent Diabetes in the BB Rat. In: Dyrberg, T. (eds) The Role of Viruses and the Immune System in Diabetes Mellitus. Current Topics in Microbiology and Immunology, vol 156. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75239-1_7
Download citation
DOI: https://doi.org/10.1007/978-3-642-75239-1_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-75241-4
Online ISBN: 978-3-642-75239-1
eBook Packages: Springer Book Archive