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The Role of Viruses and the Immune System in Diabetes Mellitus pp 75–86Cite as

Monoclonal (Auto)Antibodies in Insulin-Dependent Diabetes Mellitus

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 156))

Abstract

Insulin-dependent diabetes mellitus (IDDM) in humans, BB rats (MARLISS 1983), and nonobese diabetic (NOD) mice (MAKINO et al. 1980) is characterized by immune abnormalities leading to self-destruction of the insulin-producing islet β cells. These abnormalities have been observed in the cell-mediated as well as in the humoral immune response. Two major types of auto-antibodies have been reported, namely, islet cell cytoplasmic (ICA; BOTTAZZO et al. 1974; MAUISH et al. 1974) and islet cell surface antibodies (ICSA; LERNMARK et al. 1978). In this chapter we will review data on experimental monoclonal antibodies to islet cells with a special emphasis on autoantibodies derived from the BB rat.

G. C>ONTREAS was a recipient of a JDF fellowship, and part of the work has been supported by JDF research grant no. 188341 to OLE D. MADSEN

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Authors and Affiliations

  1. Hagedorn Research Laboratory, DK-2820, Gentofte, Denmark

    O. D. Madsen, G. Contreas & J. Jørgensen

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  1. O. D. Madsen
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  2. G. Contreas
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  3. J. Jørgensen
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  1. Hagedorn Research Laboratory, Niels Steensens Vej 6, 2820, Gentofte, Denmark

    Thomas Dyrberg M.D.

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Madsen, O.D., Contreas, G., Jørgensen, J. (1990). Monoclonal (Auto)Antibodies in Insulin-Dependent Diabetes Mellitus. In: Dyrberg, T. (eds) The Role of Viruses and the Immune System in Diabetes Mellitus. Current Topics in Microbiology and Immunology, vol 156. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75239-1_6

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