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Effects of Rubella Virus Infection on Islet Function

  • Conference paper
The Role of Viruses and the Immune System in Diabetes Mellitus

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 156))

Abstract

Viruses have been linked to the subsequent development of diabetes mellitus for at least 90 years (HARRIS 1899). The evidence to support environmental factors comes from a variety of studies including case reports in the literature, especially in regard to the congenital rubella syndrome (GINSBERG-FELLNER et al. 1985). The association of diabetes mellitus with the congenital rubella syndrome (CRS) provides the most compelling data that viruses may be directly accountable for the later onset of diabetes (RAYFIELD and ISHIMURA 1987). This chapter will first review data from human studies and then present evidence from animal models to support an association of CRS with diabetes mellitus. This is a logical sequence since it was the observations from the human studies which prompted the development of the animal models.

This work was supported in part by grants from the National Institutes of Health (NIADDK 35003) and a grant in honor of Dr. Gerald J. Friedman

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Authors and Affiliations

  1. Laboratory of Medical Biochemistry, Rockefeller University, New York, NY, USA

    E. J. Rayfield (Clinical Professor of Medicine, Mount Sinai School of Medicine Adjunct Professor)

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  1. E. J. Rayfield
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Editors and Affiliations

  1. Hagedorn Research Laboratory, Niels Steensens Vej 6, 2820, Gentofte, Denmark

    Thomas Dyrberg M.D.

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© 1990 Springer-Verlag Berlin · Heidelberg

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Rayfield, E.J. (1990). Effects of Rubella Virus Infection on Islet Function. In: Dyrberg, T. (eds) The Role of Viruses and the Immune System in Diabetes Mellitus. Current Topics in Microbiology and Immunology, vol 156. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75239-1_5

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  • DOI: https://doi.org/10.1007/978-3-642-75239-1_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75241-4

  • Online ISBN: 978-3-642-75239-1

  • eBook Packages: Springer Book Archive

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