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Immune Pathogenesis of Diabetes in the Nonobese Diabetic Mouse: An Overview

Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 156)

Abstract

A considerable amount of evidence suggests that human type 1 or insulin-dependent diabetes mellitus (IDDM) is a chronic autoimmune disease with a long preclinical period. It is extremely difficult to study the process of pancreatic beta cell damage during the preclinical stage of the disease, and only detailed analysis of animal models appears to give us some answers in this important area. In 1974 a female mouse in the normoglycemic subline of Jcl-ICR mice was found to show overt diabetes, and the nonobese diabetic (NOD) mouse strain was subsequently established in the Shionogi Laboratories (TOCHINO 1986). These mice have many characteristics similar to human type 1 diabetic patients and have been increasingly used as an animal model for type 1 diabetes (TARUI and HANAFUSA 1988). This review summarizes the current knowledge on the immune pathogenesis of diabetes in NOD mice.

Keywords

Beta Cell Islet Cell Antibody Overt Diabetes Immune Pathogenesis Diabetogenic Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1990

Authors and Affiliations

  1. 1.The Second Department of Internal MedicineOsaka University Medical SchoolOsakaJapan

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