Retroviruses pp 93-124 | Cite as

Translational Suppression in Gene Expression in Retroviruses and Retrotransposons

  • T. Jacks
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 157)

Abstract

The past 5 years have brought an exciting and very unexpected solution to a longstanding question in retrovirology: the mechanism of expression of the pol gene. Since the earliest studies of retroviral gene expression, the mechanism by which pol, the gene that encodes the critical enzymes reverse transcriptase, integrase, and sometimes protease, acts had remained an enigma. Experiments carried out recently seem to have finally settled this issue, as the pol genes of several retroviruses and one retrotransposon have been shown to be expressed by one or another form of translational suppression. This solution to the problem of pol gene expression is as unexpected as it is unusual. Even 5 year ago there was general agreement in this field that mRNA splicing would ultimately be found to be responsible for expression of the pol functions.

Keywords

Codon Leukemia Proline Polypeptide Glutamine 

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© Springer-Verlag Berlin · Heidelberg 1990

Authors and Affiliations

  • T. Jacks
    • 1
  1. 1.Whitehead InstituteNine Cambridge CenterCambridgeUSA

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