Human T-Cell Leukemia Virus Type I

  • Jörg Schüpbach
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 142)


HTLV-I was isolated after it became possible to grow human T-cells in vitro with the help of IL-2 (Morgan et al 1976; Ruscetti et al. 1977). Normal human lymphocytes that are initially stimulated with phytohemagglutinin (PHA) can be cultured for more than 1 month in the presence of IL-2. Malignant T-cells from patients with mature T-cell malignancies can be cultured using the same procedure, but without initial PHA activation. Several T-cell lines have been established from patients with mature T-cell lymphomas involving the skin (Poiesz et al. 1980a). Some of them produced particulate reverse transcriptase and released retroviral particles: the first human retroviruses had been discovered (Poiesz et al. 1980b, 1981).


Mycosis Fungoides Hairy Cell Leukemia Venezuelan Equine Encephalitis ATLL Cell Tropical Spastic Paraparesis 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Jörg Schüpbach
    • 1
  1. 1.Swiss National Center for Retroviruses, Institute of Immunology and VirologyUniversity of ZurichZurichSwitzerland

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