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The nucleoskeleton and the topology of transcription

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Book cover EJB Reviews 1989

Part of the book series: EJB Reviews ((EJB REVIEWS,volume 1989))

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Abstract

Transcription is conventionally believed to occur by passage of a mobile polymerase along a fixed template. Evidence for this model is derived almost entirely from material prepared using hypotonic salt concentrations. Studies on subnuclear structures isolated using hypertonic conditions, and more recently using conditions closer to the physiological, suggest an alternative. Transcription occurs as the template moves past a polymerase attached to a nucleoskeleton; this skeleton is the active site of transcription. Evidence for the two models is summarised. Much of it is consistent with the polymerase being attached and not freely diffusible. Some consequences of such a model are discussed.

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  1. Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK

    Peter R. Cook

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Cook, P.R. (1989). The nucleoskeleton and the topology of transcription. In: EJB Reviews 1989. EJB Reviews, vol 1989. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75189-9_10

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