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The nucleoskeleton and the topology of transcription

  • Peter R. Cook
Part of the EJB Reviews book series (EJB REVIEWS, volume 1989)

Abstract

Transcription is conventionally believed to occur by passage of a mobile polymerase along a fixed template. Evidence for this model is derived almost entirely from material prepared using hypotonic salt concentrations. Studies on subnuclear structures isolated using hypertonic conditions, and more recently using conditions closer to the physiological, suggest an alternative. Transcription occurs as the template moves past a polymerase attached to a nucleoskeleton; this skeleton is the active site of transcription. Evidence for the two models is summarised. Much of it is consistent with the polymerase being attached and not freely diffusible. Some consequences of such a model are discussed.

Keywords

Silk Fibroin Transcription Unit Chromatin Fibre Transcription Complex Negative Supercoils 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • Peter R. Cook
    • 1
  1. 1.Sir William Dunn School of PathologyUniversity of OxfordOxfordUK

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